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Sept12 Gene Detail
Summary
  • Symbol
    Sept12
  • Name
    septin 12
  • Synonyms
    1700028G04Rik, 4933413B09Rik, Septin12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918339
    NCBI Gene: 71089
  • Gene Overview
    MyGene.info: SEPT12
Location & Maps
more
  • Sequence Map
    Chr16:4986858-4997852 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10995 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SEPT12, septin 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEPT12, septin 12
    Orthology source: HomoloGene
  • Synonyms
    SPGF10
  • Links
    NCBI Gene ID: 124404
    neXtProt AC: NX_Q8IYM1

  • Chr Location
    16p13.3; chr16:4777609-4788521 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SEPT12 associations

Human Disease Mouse Models
       Spermatogenic Failure 10; SPGF10   OMIM: 614822
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Targeted
    2
Chimeric male mice are sterile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 71089 NCBI Gene Model | MGI Sequence Detail 10995 C57BL/6J ±  kb
transcript NM_027669 RefSeq | MGI Sequence Detail 2576 C57BL/6  
polypeptide NP_081945 RefSeq | MGI Sequence Detail 317 C57BL/6  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    44 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR016491 Septin
    IPR030379 Septin-type guanine nucleotide-binding (G) domain
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 3
Other
Accession IDs
less
MGI:1922898
References
more
  • Summaries
    All 19
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:186260 Yoshida A, et al., Localization of septin proteins in the mouse cochlea. Hear Res. 2012 Jul;289(1-2):40-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory