Sequence Detail

ID/Version

A0A2R8VJU7 Q9D451 Q9D9U8 (UniProt | EBI)

Last sequence update: 2018-06-20
Last annotation update: 2026-06-10

Sequence description from provider

RecName: Full=Septin 12 {ECO:0000312|MGI:MGI:1918339};

Provider

SWISS-PROT

Sequence

Polypeptide 357 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Septin12	septin 12	48	99	2	7

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:223228 Kuo YC, et al., SEPT12 orchestrates the formation of mammalian sperm annulus by organizing core octameric complexes with other SEPT proteins. J Cell Sci. 2015 Mar 1;128(5):923-34
J:242315 Shen YR, et al., SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility. PLoS Genet. 2017 Mar;13(3):e1006631
J:324492 Chen H, et al., Homozygous Loss of Septin12, but not its Haploinsufficiency, Leads to Male Infertility and Fertilization Failure. Front Cell Dev Biol. 2022;10:850052
J:381460 Zhang Y, et al., SUN5 interacts with nuclear membrane LaminB1 and cytoskeletal GTPase Septin12 mediating the sperm head-and-tail junction. Mol Hum Reprod. 2024 Jun 26;30(7)