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Kdsr Gene Detail
Summary
  • Symbol
    Kdsr
  • Name
    3-ketodihydrosphingosine reductase
  • Synonyms
    6330410P18Rik, 9430079B08Rik, Fvt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918000
    NCBI Gene: 70750
  • Gene Overview
    MyGene.info: KDSR
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:106720459-106759727 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 49.99 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918000
protein coding gene Chr1:106720410-106759742 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016372
protein coding gene Chr1:108900258-108942653 (-)
A/J MGP_AJ_G0016356
protein coding gene Chr1:105083943-105122364 (-)
AKR/J MGP_AKRJ_G0016316
protein coding gene Chr1:107956140-107994618 (-)
BALB/cJ MGP_BALBcJ_G0016312
protein coding gene Chr1:105181456-105218941 (-)
C3H/HeJ MGP_C3HHeJ_G0016139
protein coding gene Chr1:108407268-108447685 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016771
protein coding gene Chr1:113041437-113081152 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014489
protein coding gene Chr1:99389926-99427173 (-)
CAST/EiJ MGP_CASTEiJ_G0015721
protein coding gene Chr1:107328649-107371998 (-)
CBA/J MGP_CBAJ_G0016112
protein coding gene Chr1:116910307-116951280 (-)
DBA/2J MGP_DBA2J_G0016217
protein coding gene Chr1:104153229-104191600 (-)
FVB/NJ MGP_FVBNJ_G0016218
protein coding gene Chr1:103085718-103123490 (-)
LP/J MGP_LPJ_G0016291
protein coding gene Chr1:110141898-110178521 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016244
protein coding gene Chr1:121319768-121358616 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016810
protein coding gene Chr1:108044742-108085360 (-)
PWK/PhJ MGP_PWKPhJ_G0015509
protein coding gene Chr1:103176515-103212939 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015294
protein coding gene Chr1:106702102-106740368 (-)
WSB/EiJ MGP_WSBEiJ_G0015784
protein coding gene Chr1:107873842-107912944 (-)



Homology
more
  • Human Ortholog
    KDSR, 3-ketodihydrosphingosine reductase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KDSR, 3-ketodihydrosphingosine reductase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DHSR, EKVP4, FVT1, SDR35C1
  • Links
    NCBI Gene ID: 2531
    neXtProt AC: NX_Q06136
    UniProt: Q06136

  • Chr Location
    18q21.33; chr18:63327736-63367273 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000009905 Ensembl Gene Model | MGI Sequence Detail 39269 C57BL/6J ±  kb
transcript ENSMUST00000010049 Ensembl | MGI Sequence Detail 5518 Not Applicable  
polypeptide ENSMUSP00000010049 Ensembl | MGI Sequence Detail 332 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 6
Other
Accession IDs
less
MGI:2444125
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:255485 Li S, et al., Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development. Sci Rep. 2017 Oct 18;7(1):13427

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory