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Prdm16
Gene Detail
Symbol

Name
ID
Prdm16
PR domain containing 16
MGI:1917923
Synonyms
5730557K01Rik, csp1, line 27, Mel1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
83.96 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:154316125-154636873 bp, - strand
From VEGA annotation of GRCm38

  320749 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11139  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRDM16
Protein SuperFamily: transcription factor with zinc finger motifs, PRDM3/PRDM16 types
Gene Tree: Prdm16

Human
homologs
PRDM16, PR domain containing 16
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 63976
neXtProt AC: NX_Q9HAZ2

Human Synonyms: CMD1LL, LVNC8, MEL1, PFM13

Human Chr (Location): 1p36.23-p33; chr1:3068227-3438621 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PRDM16

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(9)
Genomic Mutations involving Prdm16 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant mice exhibit a cleft secondary palate.
 
Interactions
Prdm16 interacts with 423 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process brown fat cell differentiation, cell differentiation, ...
Component nucleus, transcriptional repressor complex
Function activating transcription factor binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (252)    Tissues (209)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 229
RT-PCR 23
cDNA source data(34)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prdm16 ; ZFIN prdm16    NEW 
Molecular
reagents
All nucleic(40) cDNA(34) Primer pair(5) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000010585 (Evidence)
Ensembl Gene Model ENSMUSG00000039410 (Evidence)
Entrez Gene 70673 (Evidence)
UniGene 257785
DFCI TC1581328, TC1591759, TC1604895, TC1627016
DoTS DT.60104810, DT.99852533
NIA Mouse Gene Index U025858
Consensus CDS Project CCDS38989.1, CCDS51400.1, CCDS71530.1, CCDS71532.1
International Mouse Phenotyping Consortium Status Prdm16
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010585 VEGA Gene Model | MGI Sequence Detail 320749 C57BL/6J ±  kb
transcript OTTMUST00000024684 VEGA | MGI Sequence Detail 8601 Not Applicable 
polypeptide OTTMUSP00000011335 VEGA | MGI Sequence Detail 1276 Not Applicable 

For the selected sequences
All sequences(99) RefSeq(22) UniProt(9)
Polymorphisms
SNPs within 2kb(1755 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR030413 Evi1/Prdm16
InterPro IPR030414 PR domain zinc finger protein 16
InterPro IPR001214 SET domain
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000013185 PR domain zinc finger protein 16
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:220963 Nosavanh L, et al., Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5069-74
All references(70)
Other
accession IDs
MGI:3576005

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory