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Prdm16 Gene Detail
Summary
  • Symbol
    Prdm16
  • Name
    PR domain containing 16
  • Synonyms
    5730557K01Rik, csp1, line 27, Mel1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917923
    NCBI Gene: 70673
  • Gene Overview
    MyGene.info: PRDM16
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:154316125-154636873 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 83.96 cM, cytoband E2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1749 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917923
protein coding gene Chr4:154316122-154636873 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029196
protein coding gene Chr4:158583722-158921746 (-)
A/J MGP_AJ_G0029161
protein coding gene Chr4:151923524-152247720 (-)
AKR/J MGP_AKRJ_G0029109
protein coding gene Chr4:156075220-156402446 (-)
BALB/cJ MGP_BALBcJ_G0029177
protein coding gene Chr4:152393841-152717167 (-)
C3H/HeJ MGP_C3HHeJ_G0028898
protein coding gene Chr4:156607675-156940002 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029626
protein coding gene Chr4:164248143-164590430 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026872
protein coding gene Chr4:144227428-144547814 (-)
CAST/EiJ MGP_CASTEiJ_G0028311
protein coding gene Chr4:154016739-154356188 (-)
CBA/J MGP_CBAJ_G0028860
protein coding gene Chr4:169183165-169536285 (-)
DBA/2J MGP_DBA2J_G0029009
protein coding gene Chr4:151952446-152275395 (-)
FVB/NJ MGP_FVBNJ_G0028973
protein coding gene Chr4:151158675-151487428 (-)
LP/J MGP_LPJ_G0029099
protein coding gene Chr4:158494870-158838197 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029000
protein coding gene Chr4:172096685-172428412 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029658
protein coding gene Chr4:156635756-156982774 (-)
PWK/PhJ MGP_PWKPhJ_G0028031
protein coding gene Chr4:148045196-148381886 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027865
protein coding gene Chr4:150939172-151271801 (-)
WSB/EiJ MGP_WSBEiJ_G0028391
protein coding gene Chr4:156810404-157146398 (-)



Homology
more
  • Human Ortholog
    PRDM16, PR/SET domain 16
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRDM16, PR/SET domain 16
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CMD1LL, KMT8F, LVNC8, MEL1, PFM13
  • Links
    NCBI Gene ID: 63976
    neXtProt AC: NX_Q9HAZ2
    UniProt: Q9HAZ2

  • Chr Location
    1p36.32; chr1:3069025-3438621 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    69 phenotypes from 3 alleles in 8 genetic backgrounds
    2 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutant mice exhibit a cleft secondary palate, whitening of brown adipose tissue in older or fed a high-fat diet, and impaired adaptive thermogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039410 Ensembl Gene Model | MGI Sequence Detail 320749 C57BL/6J ±  kb
    transcript ENSMUST00000105638 Ensembl | MGI Sequence Detail 8601 Not Applicable  
    polypeptide ENSMUSP00000101263 Ensembl | MGI Sequence Detail 1276 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 35
      Primer pair 5
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:3576005
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 38
      Gene Ontology 14
      Phenotypes 34
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:264335 Corrigan DJ, et al., PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signature. J Clin Invest. 2018 Aug 1;128(8):3250-3264

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory