Prdm16
Gene Detail

Symbol Name ID

Prdm16 PR domain containing 16 MGI:1917923

Synonyms

5730557K01Rik, csp1, line 27, Mel1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

83.96 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr4:154316125-154636873 bp, - strand From VEGA annotation of GRCm38   320749 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Prdm16 ± 2 cM)

Protein SuperFamily: transcription factor with zinc finger motifs, PRDM3/PRDM16 types
Gene Tree: Prdm16

Human ortholog

PRDM16 PR domain containing 16 NCBI Gene ID 63976
Human Synonyms: MEL1, PFM13
Human Chr1:2985742-3355185 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(7) : Targeted(2) Gene trapped(4) Chemically induced(1)
 

Mutant mice exhibit a cleft secondary palate.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	brown fat cell differentiation, cell differentiation, ...
Component	intracellular, nucleus, ...
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (259)    Tissues (214)    Images (11)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	229
RT-PCR	30

cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(40) cDNA(34) Primer pair(5) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000010585 (Evidence)
Ensembl Gene Model	ENSMUSG00000039410 (Evidence)
Entrez Gene	70673 (Evidence)
UniGene	257785
DFCI	TC1581328, TC1591759, TC1604895, TC1627016
DoTS	DT.60104810, DT.99852533
NIA Mouse Gene Index	U025858
Consensus CDS Project	CCDS38989.1, CCDS51400.1
International Mouse Knockout Project Status	Prdm16

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010585	VEGA Gene Model | MGI Sequence Detail	320749	C57BL/6J
transcript	OTTMUST00000024684	VEGA | MGI Sequence Detail	8601	Not Applicable
polypeptide	OTTMUSP00000011335	VEGA | MGI Sequence Detail	1276	Not Applicable

All sequences(81) RefSeq(4) UniProt(9)

Polymorphisms

SNPs(1515 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001214	SET domain
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193353 Borensztein M, et al., Double Myod and Igf2 inactivation promotes brown adipose tissue development by increasing Prdm16 expression. FASEB J. 2012 Nov;26(11):4584-91
All references(58)

Other accession IDs

MGI:3576005