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Prdm16
Gene Detail
 Symbol
Name
ID
Prdm16
PR domain containing 16
MGI:1917923
Synonyms 5730557K01Rik, csp1, line 27, Mel1
Feature Type protein coding gene
Genetic Map
Chromosome 4
83.96 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr4:154316125-154636873 bp, - strand
From VEGA annotation of GRCm38

  320749 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11139  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor with zinc finger motifs, PRDM3/PRDM16 types
Gene Tree: Prdm16

Human
homologs
Human Homolog PRDM16, PR domain containing 16
NCBI Gene ID 63976
neXtProt AC  NX_Q9HAZ2
Human Synonyms  CMD1LL, LVNC8, MEL1, PFM13
Human Chr (Location)  1p36.23-p33; chr1:3068497-3438621 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PRDM16
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(6)
Genomic Mutations involving Prdm16 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant mice exhibit a cleft secondary palate.
 
Interactions
Prdm16 interacts with 423 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process brown fat cell differentiation, cell differentiation, ...
Component nucleus, transcriptional repressor complex
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (252)    Tissues (209)    Images (11)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 229
RT-PCR 23
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(34) Primer pair(5) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000010585 (Evidence)
Ensembl Gene ModelENSMUSG00000039410 (Evidence)
Entrez Gene70673 (Evidence)
UniGene257785
DFCITC1581328, TC1591759, TC1604895, TC1627016
DoTSDT.60104810, DT.99852533
NIA Mouse Gene IndexU025858
Consensus CDS ProjectCCDS38989.1, CCDS51400.1, CCDS71530.1, CCDS71532.1
International Mouse Knockout Project StatusPrdm16
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010585 VEGA Gene Model | MGI Sequence Detail 320749 C57BL/6J ±  kb
transcript OTTMUST00000024684 VEGA | MGI Sequence Detail 8601 Not Applicable 
polypeptide OTTMUSP00000011335 VEGA | MGI Sequence Detail 1276 Not Applicable 

For the selected sequences
All sequences(99) RefSeq(22) UniProt(9)
Polymorphisms SNPs within 2kb(1755 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001214 SET domain
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000013185 PR domain zinc finger protein 16
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:208683 Cohen P, et al., Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 2014 Jan 16;156(1-2):304-16
All references(67)
Other
accession IDs
MGI:3576005

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory