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Pak4
Gene Detail
Symbol

Name
ID
Pak4
p21 protein (Cdc42/Rac)-activated kinase 4
MGI:1917834
Synonyms
5730488L07Rik, mKIAA1142
Feature Type
protein coding gene
Genetic Map
Chromosome 7
16.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:28558819-28598185 bp, - strand
From VEGA annotation of GRCm38

  39367 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4300  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pak4

Human
homologs
Human Homolog PAK4, p21 protein (Cdc42/Rac)-activated kinase 4
NCBI Gene ID 10298
neXtProt AC  NX_O96013
Human Chr (Location)  19q13.2; chr19:39125780-39179406 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(146) : Chemically induced (ENU)(1) Gene trapped(141) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die at midgestation exhibiting heart defects as well as impaired neuronal development and yolk sac vasculature.
 
Interactions
Pak4 interacts with 132 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process apoptotic process, cell cycle, ...
Component cytoplasm, focal adhesion
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (96)    Tissues (94)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 93
Western blot 3
cDNA source data(65)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(66) cDNA(65) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000025040 (Evidence)
Ensembl Gene ModelENSMUSG00000030602 (Evidence)
Entrez Gene70584 (Evidence)
UniGene21876
DFCITC1577262
DoTSDT.101373909, DT.87072376
NIA Mouse Gene IndexU028328
EC2.7.11.1
Consensus CDS ProjectCCDS21049.1
International Mouse Knockout Project StatusPak4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025040 VEGA Gene Model | MGI Sequence Detail 39367 C57BL/6J ±  kb
transcript OTTMUST00000061614 VEGA | MGI Sequence Detail 2899 Not Applicable 
polypeptide OTTMUSP00000030258 VEGA | MGI Sequence Detail 593 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(140 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000095 PAK-box/P21-Rho-binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
Protein Ontology PR:000012243 serine/threonine-protein kinase PAK 4
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194236 Dolan BM, et al., Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5671-6
All references(42)
Other
accession IDs
MGI:2142263

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory