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Pak4
Gene Detail
Symbol

Name
ID
Pak4
p21 protein (Cdc42/Rac)-activated kinase 4
MGI:1917834
Synonyms
5730488L07Rik, mKIAA1142
Feature Type
protein coding gene
Genetic Map
Chromosome 7
16.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:28558819-28598185 bp, - strand
From VEGA annotation of GRCm38

  39367 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4300  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PAK4
Gene Tree: Pak4

Human
homologs
PAK4, p21 protein (Cdc42/Rac)-activated kinase 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10298
neXtProt AC: NX_O96013

Human Chr (Location): 19q13.2; chr19:39125780-39179406 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(146) : Chemically induced (ENU)(1) Gene trapped(141) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die at midgestation exhibiting heart defects as well as impaired neuronal development and yolk sac vasculature.
 
Interactions
Pak4 interacts with 132 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (96)    Tissues (94)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 93
Western blot 3
cDNA source data(65)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pak4 ; ZFIN pak4    NEW 
Molecular
reagents
All nucleic(66) cDNA(65) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000025040 (Evidence)
Ensembl Gene Model ENSMUSG00000030602 (Evidence)
Entrez Gene 70584 (Evidence)
UniGene 21876
DFCI TC1577262
DoTS DT.101373909, DT.87072376
NIA Mouse Gene Index U028328
Consensus CDS Project CCDS21049.1
International Mouse Phenotyping Consortium Status Pak4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025040 VEGA Gene Model | MGI Sequence Detail 39367 C57BL/6J ±  kb
transcript OTTMUST00000061614 VEGA | MGI Sequence Detail 2899 Not Applicable 
polypeptide OTTMUSP00000030258 VEGA | MGI Sequence Detail 593 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(8)
Polymorphisms
SNPs within 2kb(140 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000012243 serine/threonine-protein kinase PAK 4
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194236 Dolan BM, et al., Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5671-6
All references(38)
Other
accession IDs
MGI:2142263

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory