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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Pak4
p21 (RAC1) activated kinase 4
MGI:1917834
26 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Meox2tm1(cre)Sor/Meox2+
Pak4tm2.1Amin/Pak4tm2.2Amin
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N
abnormal placenta labyrinth morphology J:152821
abnormal visceral yolk sac morphology J:152821
Pak4tm1Amin/Pak4tm1Amin
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)
abnormal axon extension J:85954
abnormal brain morphology J:85954
abnormal cell adhesion J:85954
abnormal motor neuron morphology J:85954
abnormal nervous system development J:85954
abnormal neural tube morphology J:85954
abnormal neuron differentiation J:85954
abnormal neuronal migration J:85954
abnormal ventral interneuron morphology J:85954
decreased embryo size J:85954
decreased embryonic neuroepithelium thickness J:85954
dilated heart J:85954
embryonic lethality during organogenesis, complete penetrance J:85954
thin myocardium J:85954
thin ventricular wall J:85954
Pak4tm1Amin/Pak4tm1Amin
either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J)
abnormal placenta labyrinth morphology J:152821
abnormal placenta vasculature J:152821
abnormal visceral yolk sac morphology J:152821
abnormal vitelline vascular remodeling J:152821
decreased cell proliferation J:152821
decreased embryo size J:152821
embryonic growth retardation J:152821
increased apoptosis J:152821
pale placenta J:152821
pale yolk sac J:152821
pallor J:152821
Pak4tm2.1Amin/Pak4tm2.2Amin
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N
abnormal placenta labyrinth morphology J:152821
abnormal visceral yolk sac morphology J:152821
embryonic growth retardation J:152821
preweaning lethality, complete penetrance J:152821

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory