Lrrc56 MGI Mouse Gene Detail - MGI:1917802 - leucine rich repeat containing 56

Symbol

Lrrc56
Name

leucine rich repeat containing 56
Synonyms

5730427C23Rik

Feature Type

protein coding gene
IDs

MGI:1917802
NCBI Gene: 70552
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:140774070-140789968 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 86.48 cM
Mapping Data

2 experiments

SNPs within 2kb

64 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917802	protein coding gene	Chr7:140774024-140789968 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033215	protein coding gene	Chr7:146370322-146385873 (+)
A/J	MGP_AJ_G0033197	protein coding gene	Chr7:142184770-142200333 (+)
AKR/J	MGP_AKRJ_G0033129	protein coding gene	Chr7:146103422-146120609 (+)
BALB/cJ	MGP_BALBcJ_G0033198	protein coding gene	Chr7:141925501-141941058 (+)
C3H/HeJ	MGP_C3HHeJ_G0032912	protein coding gene	Chr7:145860871-145876429 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033709	protein coding gene	Chr7:151722217-151738917 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030682	protein coding gene	Chr7:143394669-143410295 (+)
CAST/EiJ	MGP_CASTEiJ_G0032242	protein coding gene	Chr7:138169505-138185477 (+)
CBA/J	MGP_CBAJ_G0032884	protein coding gene	Chr7:156846397-156861950 (+)
DBA/2J	MGP_DBA2J_G0033036	protein coding gene	Chr7:140132310-140147866 (+)
FVB/NJ	MGP_FVBNJ_G0032989	protein coding gene	Chr7:140045052-140061037 (+)
LP/J	MGP_LPJ_G0033131	protein coding gene	Chr7:147866668-147882211 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033022	protein coding gene	Chr7:157513697-157529983 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033729	protein coding gene	Chr7:145081896-145097450 (+)
PWK/PhJ	MGP_PWKPhJ_G0031946	protein coding gene	Chr7:133412428-133428569 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031793	protein coding gene	Chr7:131908063-131924834 (+)
WSB/EiJ	MGP_WSBEiJ_G0032353	protein coding gene	Chr7:146030113-146046104 (+)

Human Ortholog

LRRC56, leucine rich repeat containing 56

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRC56, leucine rich repeat containing 56
Synonyms

CILD39, DNAAF12, oda8
Links

HGNC:25430

NCBI Gene ID: 115399

neXtProt AC: NX_Q8IYG6

UniProt: Q8IYG6
Chr Location

11p15.5; chr11:506462-554912 (+) GRCh38

MGI Vertebrate Homology

Lrrc56 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LRRC56
Gene Tree

Lrrc56

Diseases

1 with human LRRC56 associations

				Human Disease	Mouse Models
				primary ciliary dyskinesia 39 IDs primary ciliary dyskinesia 39 DOID:0111854 OMIM:618254

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Radiation induced

1
Targeted

2
Genomic Mutations

1 involving Lrrc56
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

2
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

15

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lrrc56

less

All Sequences

86
RefSeq

40
UniProt

4
CCDS

CCDS22004.1, CCDS52440.1

Ensembl

ENSMUSG00000038637 (Evidence)
NCBI Gene

70552

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038637	Ensembl Gene Model \| MGI Sequence Detail	15899	C57BL/6J	± kb
transcript	ENSMUST00000070458	Ensembl \| MGI Sequence Detail	2502	Not Applicable
polypeptide	ENSMUSP00000063912	Ensembl \| MGI Sequence Detail	552	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000029603 leucine-rich repeat-containing protein 56

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR025875 Leucine rich repeat 4

IPR040091 Leucine-rich repeat-containing protein 56

IPR032675 Leucine-rich repeat domain superfamily

less

All nucleic 16

cDNA 16

Microarray probesets 4

less

MGI:2142287

Summaries

All 29

Gene Ontology 2

Phenotypes 8
Earliest

J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Lrrc56:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69928	Chr7:140774020-140774031 (+)	-44 bp
Tssr69929	Chr7:140774035-140774053 (+)	-26 bp
Tssr69930	Chr7:140774061-140774104 (+)	13 bp
Tssr69931	Chr7:140774960-140774996 (+)	908 bp
Tssr69932	Chr7:140775044-140775059 (+)	982 bp
Tssr69933	Chr7:140776763-140776771 (+)	2,697 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23