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Atp6ap2
Gene Detail
 Symbol
Name
ID
Atp6ap2
ATPase, H+ transporting, lysosomal accessory protein 2
MGI:1917745
Synonyms 5730403E06Rik, Atp6ip2, M8-9, (P)RR, renin/prorenin receptor
Feature Type protein coding gene
Genetic Map
Chromosome X
7.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:12587801-12617049 bp, + strand
From VEGA annotation of GRCm38

  29249 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38097  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Atp6ap2

Human
homologs
Human Homolog ATP6AP2, ATPase, H+ transporting, lysosomal accessory protein 2
NCBI Gene ID 10159
neXtProt AC  NX_O75787
Human Synonyms  APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, M8-9, MRXE, MRXSH, MSTP009, PRR, RENR, XMRE, XPDS
Human Chr (Location)  Xp11.4; chrX:40580964-40606637 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human ATP6AP2
Mutations,
alleles, and
phenotypes
All mutations/alleles(51) : Gene trapped(50) Targeted(1)
Interactions
Atp6ap2 interacts with 184 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process angiotensin maturation, eye pigmentation, ...
Component cell body, external side of plasma membrane, ...
Function aspartic-type endopeptidase activity, enzyme binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (15)    Tissues (11)    Images (8)
Theiler Stages: 22, 24, 26, 28
Assay TypeResults
RNA in situ 15
cDNA source data(195)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(196) cDNA(196)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016967 (Evidence)
Ensembl Gene ModelENSMUSG00000031007 (Evidence)
Entrez Gene70495 (Evidence)
UniGene25148
DFCITC1573487, TC1668512, TC1710526
DoTSDT.533745
NIA Mouse Gene IndexU019711
Consensus CDS ProjectCCDS30023.1
International Mouse Knockout Project StatusAtp6ap2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016967 VEGA Gene Model | MGI Sequence Detail 29249 C57BL/6J ±  kb
transcript OTTMUST00000041135 VEGA | MGI Sequence Detail 2324 Not Applicable 
polypeptide OTTMUSP00000018429 VEGA | MGI Sequence Detail 350 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012493 Renin receptor-like
Protein Ontology PR:000004470 renin receptor
References (Earliest) J:47435 Ludwig J, et al., Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules. J Biol Chem. 1998 May 1;273(18):10939-47
(Latest) J:204145 Kanda A, et al., Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice. J Neurosci. 2013 Dec 4;33(49):19341-51
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory