Atp6ap2
Gene Detail

Symbol Name ID

Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 MGI:1917745

Synonyms

5730403E06Rik, Atp6ip2, M8-9, (P)RR, renin/prorenin receptor

Feature Type

protein coding gene

Genetic Map

Chromosome X

7.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

ChrX:12587801-12617049 bp, + strand From VEGA annotation of GRCm38   29249 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38097  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Atp6ap2

Human homologs

Human Homolog		ATP6AP2, ATPase, H+ transporting, lysosomal accessory protein 2
NCBI Gene ID		10159
neXtProt AC		NX_O75787
Human Synonyms		APT6M8-9, ATP6IP2, ATP6M8-9, ELDF10, M8-9, MRXE, MSTP009, XMRE
Human Chr (Location)		Xp11.4; chrX:40440216-40465889 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ATP6AP2

Alleles and phenotypes

All alleles(51) : Targeted(1) Gene trapped(50)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	angiotensin maturation, positive regulation of transforming growth factor beta1 production, ...
Component	cell body, external side of plasma membrane, ...
Function	aspartic-type endopeptidase activity, enzyme binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (15)    Tissues (11)    Images (8)
Theiler Stages: 22, 24, 26, 28

Assay Type	Results
RNA in situ	15

cDNA source data(192)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(193) cDNA(193)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016967 (Evidence)
Ensembl Gene Model	ENSMUSG00000031007 (Evidence)
Entrez Gene	70495 (Evidence)
UniGene	25148
DFCI	TC1573487, TC1668512, TC1710526
DoTS	DT.533745
NIA Mouse Gene Index	U019711
Consensus CDS Project	CCDS30023.1
International Mouse Knockout Project Status	Atp6ap2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016967	VEGA Gene Model | MGI Sequence Detail	29249	C57BL/6J
transcript	OTTMUST00000041135	VEGA | MGI Sequence Detail	2324	Not Applicable
polypeptide	OTTMUSP00000018429	VEGA | MGI Sequence Detail	350	Not Applicable

All sequences(31) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(84 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012493	Renin receptor-like
Protein Ontology	PR:000004470	renin receptor

References

(Earliest) J:47435 Ludwig J, et al., Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules. J Biol Chem. 1998 May 1;273(18):10939-47
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)