Gene Expression Literature Summary

• Symbol: Atp6ap2
• Name: ATPase, H+ transporting, lysosomal accessory protein 2
• ID: MGI:1917745

10 matching records from 10 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9.5	E10.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E18	E18.5	P
Immunohistochemistry (section)				1		2		1		1		1		2	3
In situ RNA (section)							1	1			1		1		1
Western blot				1				1	1			1		1	1
RT-PCR	1	1	1		1	1		2				2		2	3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Atp6ap2  ATPase, H+ transporting, lysosomal accessory protein 2   (Synonyms: 5730403E06Rik, Atp6ip2, M8-9, (P)RR, renin/prorenin receptor)
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
4*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
8*	J:218046 Cuffe JS, Walton SL, Steane SE, Singh RR, Simmons DG, Moritz KM, The effects of gestational age and maternal hypoxia on the placental renin angiotensin system in the mouse. Placenta. 2014 Nov;35(11):953-61
1	J:379436 Hashimoto M, Hibi M, Matsukubo K, Kimura H, Hiraoka K, Biswas SP, Suzuki-Nakagawa C, Kizuka Y, Kim JD, Fukamizu A, Ichihara A, Nakagawa T, Neural stem cell-specific deficiency of (pro)renin receptor causes brain malformation and perinatal lethality in mice. J Biochem. 2025 Nov 4;178(5):355-367
2	J:296116 Hirose T, Cabrera-Socorro A, Chitayat D, Lemonnier T, Feraud O, Cifuentes-Diaz C, Gervasi N, Mombereau C, Ghosh T, Stoica L, Bacha JDA, Yamada H, Lauterbach MA, Guillon M, Kaneko K, Norris JW, Siriwardena K, Blaser S, Teillon J, Mendoza-Londono R, Russeau M, Hadoux J, Ito S, Corvol P, Matheus MG, Holden KR, Takei K, Emiliani V, Bennaceur-Griscelli A, Schwartz CE, Nguyen G, Groszer M, ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration. J Clin Invest. 2019 Apr 15;129(5):2145-2162
12	J:277670 Liu J, Zhou Y, Liu Y, Li L, Chen Y, Liu Y, Feng Y, Yosypiv IV, Song R, Peng H, (Pro)renin receptor regulates lung development via the Wnt/beta-catenin signaling pathway. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 1;317(2):L202-L211
3	J:223201 Song R, Preston G, Ichihara A, Yosypiv IV, Deletion of the prorenin receptor from the ureteric bud causes renal hypodysplasia. PLoS One. 2013;8(5):e63835
1	J:228872 Song R, Preston G, Kidd L, Bushnell D, Sims-Lucas S, Bates CM, Yosypiv IV, Prorenin receptor is critical for nephron progenitors. Dev Biol. 2016 Jan 15;409(2):382-91
1*	J:378998 Yosypiv IV, Liu H, Nakhoul NL, Vacuolar ATPase regulates ureteric bud branching morphogenesis during kidney development. Am J Physiol Regul Integr Comp Physiol. 2026 Feb 1;330(2):R166-R173
3	J:275548 Yosypiv IV, Sequeira-Lopez MLS, Song R, De Goes Martini A, Stromal prorenin receptor is critical for normal kidney development. Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R640-R650