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Mipep Gene Detail
Summary
  • Symbol
    Mipep
  • Name
    mitochondrial intermediate peptidase
  • Synonyms
    5730405E07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917728
    NCBI Gene: 70478
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:61022022-61142927 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 31.95 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2977 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917728
 protein coding gene Chr14:61022011-61142930 (+)
129S1/SvImJ ENSMUSG00200041054
 protein coding gene Chr14:49615150-49736125 (+)
A/J ENSMUSG00195029410
 protein coding gene Chr14:49797296-49905389 (+)
AKR/J ENSMUSG00220028236
 protein coding gene Chr14:49144504-49252604 (+)
BALB/cJ ENSMUSG00180051395
 protein coding gene Chr14:49419181-49527272 (+)
C3H/HeJ ENSMUSG00175044419
 protein coding gene Chr14:51157684-51272017 (+)
C57BL/6NJ ENSMUSG00215048636
 protein coding gene Chr14:49348493-49469461 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019378
 protein coding gene Chr14:51960138-52067662 (+)
CAST/EiJ ENSTCUG00005048813
 protein coding gene Chr14:51083864-51191244 (+)
CBA/J ENSMUSG00210044327
 protein coding gene Chr14:49785365-49893449 (+)
DBA/2J ENSMUSG00185029669
 protein coding gene Chr14:54955386-55069724 (+)
FVB/NJ ENSMUSG00205040592
 protein coding gene Chr14:49281073-49400596 (+)
JF1/MsJ ENSUMUG00000044057
 protein coding gene Chr14:66150249-66259231 (+)
LP/J ENSMUSG00230035583
 protein coding gene Chr14:66978431-67099397 (+)
NOD/ShiLtJ ENSMUSG00190046113
 protein coding gene Chr14:49581369-49702320 (+)
NZO/HlLtJ ENSMUSG00225045754
 protein coding gene Chr14:57322939-57443898 (+)
PWK/PhJ ENSLUMG00010042524
 protein coding gene Chr14:49034207-49155164 (+)
SPRET/EiJ ENSMSPG00010030786
 protein coding gene Chr14:52459488-52565511 (+)
WSB/EiJ ENSIUOG00005038626
 protein coding gene Chr14:49016666-49124740 (+)



Homology
more
  • Human Ortholog
    MIPEP, mitochondrial intermediate peptidase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MIPEP, mitochondrial intermediate peptidase
  • Synonyms
    COXPD31, HMIP, MIP
  • Links
    NCBI Gene ID: 4285
    UniProt: Q99797

  • Chr Location
    13q12.12; chr13:23730176-23889448 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mipep mouse models; 1 with human MIPEP associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Adipocyte-specific knock-out mice exhibit increased weight, lipoatrophy in white adipose tissue, whitening of brown adipose tissue, impaired adipocyte differentiation and abnormal adipocyte mitochondria, adipose tissue and systemic inflammation, fatty liver, and impaired glucose metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    2
  • cDNA Data
    13
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021993 Ensembl Gene Model | MGI Sequence Detail 120906 C57BL/6J ±  kb
    transcript ENSMUST00000224635 Ensembl | MGI Sequence Detail 3442 Not Applicable  
    polypeptide ENSMUSP00000153502 Ensembl | MGI Sequence Detail 711 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 7
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 10
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:365489 Nozaki Y, et al., Mipep deficiency in adipocytes impairs mitochondrial protein maturation and leads to systemic inflammation and metabolic dysfunctions. Sci Rep. 2025 Apr 14;15(1):12839
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory