Mipep^tm1.1Yhig
Targeted Allele Detail

Summary

• Symbol: Mipep^tm1.1Yhig
• Name: mitochondrial intermediate peptidase; targeted mutation 1.1, Yoshikazu Higami
• MGI ID: MGI:8190793
• Synonyms: Mipep^flox
• Gene: Mipep Location: Chr14:61022022-61142927 bp, + strand Genetic Position: Chr14, 31.95 cM, cytoband C3
• Alliance: Mipep^tm1.1Yhig page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:365489
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 13, which encodes zinc-binding sites essential for enzymatic activity, was flanked by loxP sites and an FRT-flanked PGK-neomycin selectin cassette was inserted downstream of the second loxP site. Flp-mediated recombination deleted the PGK-neomycin selection cassette, leaving exon 13 floxed. (J:365489)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mipep Mutation: 46 strains or lines available

References

• Original: J:365489 Nozaki Y, et al., Mipep deficiency in adipocytes impairs mitochondrial protein maturation and leads to systemic inflammation and metabolic dysfunctions. Sci Rep. 2025 Apr 14;15(1):12839
• All: 1 reference(s)