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Rapgef4
Gene Detail
 Symbol
Name
ID
Rapgef4
Rap guanine nucleotide exchange factor (GEF) 4
MGI:1917723
Synonyms 1300003D15Rik, 5730402K07Rik, 6330581N18Rik, cAMP-GEFII, Epac2
Feature Type protein coding gene
Genetic Map
Chromosome 2
42.90 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:71981240-72257474 bp, + strand
From VEGA annotation of GRCm38

  276235 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4451  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rapgef4

Human
homologs
Human Homolog RAPGEF4, Rap guanine nucleotide exchange factor (GEF) 4
NCBI Gene ID 11069
neXtProt AC  NX_Q8WZA2
Human Synonyms  2, CAMP-GEFII, CGEF2, EPAC, EPAC2, EPAC 2, Nbla00496
Human Chr (Location)  2q31-q32; chr2:172735399-173052893 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased insulin granule fusion in pancreatic islet cells during the first phase of cAMP-dependent insulin granule exocytosis. Mice homozygous for a knock-out allele exhibit impaired isoproterenol-induced SR calcium leak and arrhythmia.
 
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process calcium ion-dependent exocytosis, cAMP-mediated signaling, ...
Component apical plasma membrane, axon, ...
Function cAMP binding, cAMP-dependent protein kinase regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (55)    Tissues (13)    Images (17)
Theiler Stages: 23, 26, 28
Assay TypeResults
RNA in situ 35
RT-PCR 20
cDNA source data(45)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(46) cDNA(45) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000013137 (Evidence)
Ensembl Gene ModelENSMUSG00000049044 (Evidence)
Entrez Gene56508 (Evidence)
UniGene196153
DFCITC1583051, TC1590797, TC1597330, TC1607166, TC1607845, TC1626341
DoTSDT.101363434, DT.486250, DT.55117120, DT.55162850, DT.55214199, DT.55233823, DT.91364304, DT.94132871, DT.97397435, DT.99840532
NIA Mouse Gene IndexU001909, U043904, U044599, U263905
PDB1O7F, 2BYV, 4F7Z, 3CF6
Consensus CDS ProjectCCDS16120.1, CCDS57176.1, CCDS57177.1
International Mouse Knockout Project StatusRapgef4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013137 VEGA Gene Model | MGI Sequence Detail 276235 C57BL/6J ±  kb
transcript OTTMUST00000031708 VEGA | MGI Sequence Detail 4181 Not Applicable 
polypeptide OTTMUSP00000014132 VEGA | MGI Sequence Detail 1011 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(16) UniProt(5)
Polymorphisms SNPs within 2kb(2694 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002373 cAMP/cGMP-dependent protein kinase
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR000591 DEP domain
InterPro IPR001895 Guanine-nucleotide dissociation stimulator CDC25
InterPro IPR019804 Ras guanine-nucleotide exchange factor, conserved site
InterPro IPR023578 Ras guanine nucleotide exchange factor, domain
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
InterPro IPR014710 RmlC-like jelly roll fold
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000013729 rap guanine nucleotide exchange factor 4
References (Earliest) J:71886 Ozaki N, et al., cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000 Nov;2(11):805-11
(Latest) J:210426 Pereira L, et al., Epac2 mediates cardiac beta1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26;127(8):913-22
All references(52)
Other
accession IDs
MGI:1918994, MGI:2442054

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory