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Rapgef4 Gene Detail
Summary
  • Symbol
    Rapgef4
  • Name
    Rap guanine nucleotide exchange factor (GEF) 4
  • Synonyms
    1300003D15Rik, 5730402K07Rik, 6330581N18Rik, cAMP-GEFII, Epac2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917723
    NCBI Gene: 56508
  • Gene Overview
    MyGene.info: RAPGEF4
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:71981240-72257474 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 42.90 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2668 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917723
protein coding gene Chr2:71981215-72257474 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025828
protein coding gene Chr2:72150945-72440244 (+)
A/J MGP_AJ_G0025806
protein coding gene Chr2:69317495-69598312 (+)
AKR/J MGP_AKRJ_G0025774
protein coding gene Chr2:71236879-71532365 (+)
BALB/cJ MGP_BALBcJ_G0025800
protein coding gene Chr2:69515723-69802550 (+)
C3H/HeJ MGP_C3HHeJ_G0025560
protein coding gene Chr2:71436538-71721054 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026247
protein coding gene Chr2:74326562-74617945 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023650
protein coding gene Chr2:66533461-66832361 (+)
CAST/EiJ MGP_CASTEiJ_G0025024
protein coding gene Chr2:71637042-71927099 (+)
CBA/J MGP_CBAJ_G0025541
protein coding gene Chr2:77035532-77355229 (+)
DBA/2J MGP_DBA2J_G0025672
protein coding gene Chr2:68950482-69226887 (+)
FVB/NJ MGP_FVBNJ_G0025634
protein coding gene Chr2:68357302-68636074 (+)
LP/J MGP_LPJ_G0025760
protein coding gene Chr2:72035462-72324440 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025665
protein coding gene Chr2:79018277-79316505 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026304
protein coding gene Chr2:71323802-71606765 (+)
PWK/PhJ MGP_PWKPhJ_G0024765
protein coding gene Chr2:68831644-69112620 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024573
protein coding gene Chr2:71513343-71808809 (+)
WSB/EiJ MGP_WSBEiJ_G0025092
protein coding gene Chr2:71766064-72058167 (+)



Homology
more
  • Human Ortholog
    RAPGEF4, Rap guanine nucleotide exchange factor 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAPGEF4, Rap guanine nucleotide exchange factor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAMP-GEFII, CGEF2, EPAC, EPAC2, EPAC 2, Nbla00496
  • Links
    NCBI Gene ID: 11069
    neXtProt AC: NX_Q8WZA2
    UniProt: Q8WZA2

  • Chr Location
    2q31.1; chr2:172735282-173052893 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased insulin granule fusion in pancreatic islet cells during the first phase of cAMP-dependent insulin granule exocytosis. Mice homozygous for a knock-out allele exhibit impaired isoproterenol-induced SR calcium leak and arrhythmia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049044 Ensembl Gene Model | MGI Sequence Detail 276235 C57BL/6J ±  kb
transcript ENSMUST00000090826 Ensembl | MGI Sequence Detail 4181 Not Applicable  
polypeptide ENSMUSP00000088336 Ensembl | MGI Sequence Detail 1011 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    cDNA 48
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1918994, MGI:2442054
References
more
  • Summaries
    All 79
    Developmental Gene Expression 4
    Gene Ontology 11
    Phenotypes 33
  • Earliest
    J:71886 Ozaki N, et al., cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000 Nov;2(11):805-11
  • Latest
    J:264090 Aesoy R, et al., Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice. PLoS One. 2018;13(7):e0200935

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory