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Rapgef4
Gene Detail
Symbol

Name
ID
Rapgef4
Rap guanine nucleotide exchange factor (GEF) 4
MGI:1917723
Synonyms
1300003D15Rik, 5730402K07Rik, 6330581N18Rik, cAMP-GEFII, Epac2
Feature Type
protein coding gene
Genetic Map
Chromosome 2
42.90 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:71981240-72257474 bp, + strand
From VEGA annotation of GRCm38

  276235 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4451  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rapgef4

Human
homologs
Human Homolog RAPGEF4, Rap guanine nucleotide exchange factor (GEF) 4
NCBI Gene ID 11069
neXtProt AC  NX_Q8WZA2
Human Synonyms  2, CAMP-GEFII, CGEF2, EPAC, EPAC2, EPAC 2, Nbla00496
Human Chr (Location)  2q31-q32; chr2:172735399-173052893 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Genomic Mutations involving Rapgef4 (4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased insulin granule fusion in pancreatic islet cells during the first phase of cAMP-dependent insulin granule exocytosis. Mice homozygous for a knock-out allele exhibit impaired isoproterenol-induced SR calcium leak and arrhythmia.
 
Interactions
Rapgef4 interacts with 314 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process calcium ion-dependent exocytosis, cAMP-mediated signaling, ...
Component apical plasma membrane, axon, ...
Function cAMP binding, cAMP-dependent protein kinase regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (55)    Tissues (17)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 35
RT-PCR 20
cDNA source data(45)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) cDNA(45) Primer pair(1)
Microarray probesets(7)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013137 VEGA Gene Model | MGI Sequence Detail 276235 C57BL/6J ±  kb
transcript OTTMUST00000031708 VEGA | MGI Sequence Detail 4181 Not Applicable 
polypeptide OTTMUSP00000014132 VEGA | MGI Sequence Detail 1011 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(16) UniProt(9)
Polymorphisms
SNPs within 2kb(2694 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002373 cAMP/cGMP-dependent protein kinase
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR000591 DEP domain
InterPro IPR001895 Guanine-nucleotide dissociation stimulator CDC25
InterPro IPR019804 Ras guanine-nucleotide exchange factor, conserved site
InterPro IPR023578 Ras guanine nucleotide exchange factor, domain
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
InterPro IPR014710 RmlC-like jelly roll fold
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000013729 rap guanine nucleotide exchange factor 4
References
(Earliest) J:71886 Ozaki N, et al., cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000 Nov;2(11):805-11
(Latest) J:210426 Pereira L, et al., Epac2 mediates cardiac beta1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26;127(8):913-22
All references(52)
Other
accession IDs
MGI:1918994, MGI:2442054

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory