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Rapgef4 Gene Detail
Summary
  • Symbol
    Rapgef4
  • Name
    Rap guanine nucleotide exchange factor (GEF) 4
  • Synonyms
    1300003D15Rik, 5730402K07Rik, 6330581N18Rik, cAMP-GEFII, Epac2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917723
    NCBI Gene: 56508
  • Gene Overview
    MyGene.info: RAPGEF4
Location & Maps
more
  • Sequence Map
    Chr2:71981240-72257474 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      276235 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 42.90 cM, cytoband C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RAPGEF4, Rap guanine nucleotide exchange factor 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAPGEF4, Rap guanine nucleotide exchange factor 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAMP-GEFII, CGEF2, EPAC, EPAC2, EPAC 2, Nbla00496
  • Links
    NCBI Gene ID: 11069
    neXtProt AC: NX_Q8WZA2

  • Chr Location
    2q31-q32; chr2:172735279-173052893 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Targeted
    10
  • Genomic Mutations
    7 involving Rapgef4
  • Incidental Mutations
Mice homozygous for a null allele exhibit decreased insulin granule fusion in pancreatic islet cells during the first phase of cAMP-dependent insulin granule exocytosis. Mice homozygous for a knock-out allele exhibit impaired isoproterenol-induced SR calcium leak and arrhythmia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013137 VEGA Gene Model | MGI Sequence Detail 276235 C57BL/6J ±  kb
transcript OTTMUST00000031708 VEGA | MGI Sequence Detail 4181 Not Applicable  
polypeptide OTTMUSP00000014132 VEGA | MGI Sequence Detail 1011 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2668 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 46
    cDNA 45
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1918994, MGI:2442054
References
more
  • Summaries
    All 56
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 25
  • Earliest
    J:71886 Ozaki N, et al., cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000 Nov;2(11):805-11
  • Latest
    J:231815 Liu X, et al., Epac Signaling Is Required for Cocaine-Induced Change in AMPA Receptor Subunit Composition in the Ventral Tegmental Area. J Neurosci. 2016 Apr 27;36(17):4802-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory