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Wwtr1 Gene Detail
Summary
  • Symbol
    Wwtr1
  • Name
    WW domain containing transcription regulator 1
  • Synonyms
    2310058J06Rik, 2610021I22Rik, TAZ, transcriptional coactivator with PDZ binding motif
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917649
    NCBI Gene: 97064
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:57363070-57483331 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 27.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3371 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917649
 protein coding gene Chr3:57363065-57483331 (-)
129S1/SvImJ ENSMUSG00200022715
 protein coding gene Chr3:54233918-54354184 (-)
A/J ENSMUSG00195031537
 protein coding gene Chr3:54138277-54264957 (-)
AKR/J ENSMUSG00220028838
 protein coding gene Chr3:54203748-54324028 (-)
BALB/cJ ENSMUSG00180023164
 protein coding gene Chr3:54230386-54350660 (-)
C3H/HeJ ENSMUSG00175008481
 protein coding gene Chr3:54071818-54192082 (-)
C57BL/6NJ ENSMUSG00215007205
 protein coding gene Chr3:54515866-54636143 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025006
 protein coding gene Chr3:50893854-51013697 (-)
CAST/EiJ ENSTCUG00005002379
 protein coding gene Chr3:53842801-53962059 (-)
CBA/J ENSMUSG00210003348
 protein coding gene Chr3:54187535-54307793 (-)
DBA/2J ENSMUSG00185027056
 protein coding gene Chr3:54352293-54480237 (-)
FVB/NJ ENSMUSG00205003384
 protein coding gene Chr3:53333554-53460521 (-)
JF1/MsJ ENSUMUG00000001387
 protein coding gene Chr3:53757806-53877327 (-)
LP/J ENSMUSG00230003675
 protein coding gene Chr3:56370702-56490966 (-)
NOD/ShiLtJ ENSMUSG00190028376
 protein coding gene Chr3:54548601-54668871 (-)
NZO/HlLtJ ENSMUSG00225015732
 protein coding gene Chr3:58983121-59103381 (-)
PWK/PhJ ENSLUMG00010005268
 protein coding gene Chr3:53864513-53987138 (-)
SPRET/EiJ ENSMSPG00010007364
 protein coding gene Chr3:54721199-54847894 (-)
WSB/EiJ ENSIUOG00005007870
 protein coding gene Chr3:54321829-54441019 (-)



Homology
more
  • Human Ortholog
    WWTR1, WW domain containing transcription regulator 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WWTR1, WW domain containing transcription regulator 1
  • Synonyms
    TAZ
  • Links
    NCBI Gene ID: 25937
    UniProt: Q9GZV5

  • Chr Location
    3q25.1; chr3:149517235-149736714 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Wwtr1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    68 phenotypes from 7 alleles in 9 genetic backgrounds
    21 phenotypes from multigenic genotypes
    6 images
    254 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display polycystic kidneys, elevated blood urea nitrogen, partial postnatal lethality, premature death, reduced litter sizes, and mildly reduced body size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    99
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    837
  • Tissues
    106
  • cDNA Data
    103
  • Literature Summary
    84
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027803 Ensembl Gene Model | MGI Sequence Detail 120262 C57BL/6J ±  kb
    transcript ENSMUST00000120977 Ensembl | MGI Sequence Detail 4533 Not Applicable  
    polypeptide ENSMUSP00000113040 Ensembl | MGI Sequence Detail 452 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 103
      Primer pair 7
      Antibodies 11

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917177, MGI:2140055
    References
    more
    • Summaries
      All 414
      Developmental Gene Expression 84
      Diseases 2
      Gene Ontology 24
      Phenotypes 254
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:390819 Maimets M, et al., Engineered intestinal crypt geometry uncovers YAP1-dependent fetal-to-adult transition. Cell Stem Cell. 2026 Mar 5;33(3):487-501.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory