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Wwtr1
Gene Detail
 Symbol
Name
ID
Wwtr1
WW domain containing transcription regulator 1
MGI:1917649
Synonyms 2310058J06Rik, 2610021I22Rik, TAZ, transcriptional coactivator with PDZ binding motif
Feature Type protein coding gene
Genetic Map
Chromosome 3
27.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:57455649-57575910 bp, - strand
From VEGA annotation of GRCm38

  120262 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9159  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Wwtr1

Human
homologs
Human Homolog WWTR1, WW domain containing transcription regulator 1
NCBI Gene ID 25937
neXtProt AC  NX_Q9GZV5
Human Synonyms  TAZ
Human Chr (Location)  3q23-q24; chr3:149517235-149703273 (-)  GRCh38
Alleles
and
phenotypes
All alleles(15) : Gene trapped(8) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display polycystic kidneys, elevated blood urea nitrogen, partial postnatal lethality, premature death, reduced litter sizes, and mildly reduced body size.
 
Human Diseases Modeled Using Mouse Wwtr1 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process cilium morphogenesis, glomerulus development, ...
Component cytoplasm, nucleus, ...
Function protein binding, protein homodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (114)    Tissues (35)    Images (27)
Theiler Stages: 15, 17, 19, 20, 23
Assay TypeResults
RNA in situ 112
RT-PCR 2
cDNA source data(101)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(102) cDNA(101) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000029047 (Evidence)
Ensembl Gene ModelENSMUSG00000027803 (Evidence)
Entrez Gene97064 (Evidence)
UniGene405029
DFCITC1576108, TC1649923
DoTSDT.101296818, DT.530148, DT.94155092
NIA Mouse Gene IndexU024068
Consensus CDS ProjectCCDS38434.1, CCDS50912.1
International Mouse Knockout Project StatusWwtr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029047 VEGA Gene Model | MGI Sequence Detail 120262 C57BL/6J ±  kb
transcript OTTMUST00000072074 VEGA | MGI Sequence Detail 4533 Not Applicable 
polypeptide OTTMUSP00000037016 VEGA | MGI Sequence Detail 452 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(963 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001202 WW domain
Protein Ontology PR:000017466 WW domain-containing transcription regulator protein 1
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:203771 Byun MR, et al., FGF2 stimulates osteogenic differentiation through ERK induced TAZ expression. Bone. 2014 Jan;58:72-80
All references(62)
Other
accession IDs
MGI:1917177, MGI:2140055

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory