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Wwtr1 Gene Detail
Summary
  • Symbol
    Wwtr1
  • Name
    WW domain containing transcription regulator 1
  • Synonyms
    2310058J06Rik, 2610021I22Rik, TAZ, transcriptional coactivator with PDZ binding motif
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917649
    NCBI Gene: 97064
  • Gene Overview
    MyGene.info: WWTR1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:57455649-57575910 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 27.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    956 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917649
protein coding gene Chr3:57455644-57575910 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027229
protein coding gene Chr3:56245947-56370050 (-)
A/J MGP_AJ_G0027189
protein coding gene Chr3:54494219-54617335 (-)
AKR/J MGP_AKRJ_G0027159
protein coding gene Chr3:55627829-55751358 (-)
BALB/cJ MGP_BALBcJ_G0027202
protein coding gene Chr3:54330060-54450965 (-)
C3H/HeJ MGP_C3HHeJ_G0026945
protein coding gene Chr3:55822488-55944126 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027648
protein coding gene Chr3:58328682-58454060 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025006
protein coding gene Chr3:50893854-51013697 (-)
CAST/EiJ MGP_CASTEiJ_G0026397
protein coding gene Chr3:55982588-56108692 (-)
CBA/J MGP_CBAJ_G0026921
protein coding gene Chr3:60255057-60387447 (-)
DBA/2J MGP_DBA2J_G0027055
protein coding gene Chr3:53996547-54123447 (-)
FVB/NJ MGP_FVBNJ_G0027023
protein coding gene Chr3:52975011-53097747 (-)
LP/J MGP_LPJ_G0027167
protein coding gene Chr3:56979819-57111279 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027041
protein coding gene Chr3:64357248-64480786 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027706
protein coding gene Chr3:55564093-55688711 (-)
PWK/PhJ MGP_PWKPhJ_G0026129
protein coding gene Chr3:53648693-53772683 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025942
protein coding gene Chr3:55253542-55376007 (-)
WSB/EiJ MGP_WSBEiJ_G0026471
protein coding gene Chr3:55654867-55774084 (-)



Homology
more
  • Human Ortholog
    WWTR1, WW domain containing transcription regulator 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WWTR1, WW domain containing transcription regulator 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TAZ
  • Links
    NCBI Gene ID: 25937
    neXtProt AC: NX_Q9GZV5
    UniProt: Q9GZV5

  • Chr Location
    3q25.1; chr3:149517235-149724783 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Wwtr1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 7 alleles in 9 genetic backgrounds
    19 phenotypes from multigenic genotypes
    6 images
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display polycystic kidneys, elevated blood urea nitrogen, partial postnatal lethality, premature death, reduced litter sizes, and mildly reduced body size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027803 Ensembl Gene Model | MGI Sequence Detail 120262 C57BL/6J ±  kb
    transcript ENSMUST00000120977 Ensembl | MGI Sequence Detail 4533 Not Applicable  
    polypeptide ENSMUSP00000113040 Ensembl | MGI Sequence Detail 452 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 104
      cDNA 102
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917177, MGI:2140055
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 40
      Diseases 2
      Gene Ontology 18
      Phenotypes 66
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:265856 Xiong J, et al., The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation. Bone. 2018 Jul;112:1-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory