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Wwtr1 Gene Detail
Summary
  • Symbol
    Wwtr1
  • Name
    WW domain containing transcription regulator 1
  • Synonyms
    2310058J06Rik, 2610021I22Rik, TAZ, transcriptional coactivator with PDZ binding motif
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917649
    NCBI Gene: 97064
  • Gene Overview
    MyGene.info: WWTR1
Location & Maps
more
  • Sequence Map
    Chr3:57455649-57575910 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      120262 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 27.74 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    WWTR1, WW domain containing transcription regulator 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WWTR1, WW domain containing transcription regulator 1
    Orthology source: HomoloGene
  • Synonyms
    TAZ
  • Links
    NCBI Gene ID: 25937
    neXtProt AC: NX_Q9GZV5

  • Chr Location
    3q23-q24; chr3:149517235-149703273 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Wwtr1 mouse models

Human Disease Mouse Models
       Glomerulocystic Kidney Disease with Hyperuricemia and Isosthenuria   OMIM: 609886 View 1 model
Pulmonary Disease, Chronic Obstructive; COPD   OMIM: 606963 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 7 alleles in 9 genetic backgrounds
    16 phenotypes from multigenic genotypes
    6 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Gene trapped
    8
  • Radiation induced
    2
  • Targeted
    7
  • Genomic Mutations
    2 involving Wwtr1
  • Incidental Mutations
Mice homozygous for a null mutation display polycystic kidneys, elevated blood urea nitrogen, partial postnatal lethality, premature death, reduced litter sizes, and mildly reduced body size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029047 VEGA Gene Model | MGI Sequence Detail 120262 C57BL/6J ±  kb
transcript OTTMUST00000072074 VEGA | MGI Sequence Detail 4533 Not Applicable  
polypeptide OTTMUSP00000037016 VEGA | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    956 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000017466 WW domain-containing transcription regulator protein 1
  • InterPro Domains
    IPR001202 WW domain
Molecular
Reagents
less
  • All nucleic 103
    cDNA 101
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1917177, MGI:2140055
References
more
  • Summaries
    All 71
    Developmental Gene Expression 22
    Diseases 3
    Gene Ontology 17
    Phenotypes 28
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:229010 Wang J, et al., Yap and Taz play a crucial role in neural crest-derived craniofacial development. Development. 2016 Feb 1;143(3):504-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory