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Wwtr1
Gene Detail
Symbol

Name
ID
Wwtr1
WW domain containing transcription regulator 1
MGI:1917649
Synonyms
2310058J06Rik, 2610021I22Rik, TAZ, transcriptional coactivator with PDZ binding motif
Feature Type
protein coding gene
Genetic Map
Chromosome 3
27.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:57455649-57575910 bp, - strand
From VEGA annotation of GRCm38

  120262 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9159  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WWTR1
Gene Tree: Wwtr1

Human
homologs
WWTR1, WW domain containing transcription regulator 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 25937
neXtProt AC: NX_Q9GZV5

Human Synonyms: TAZ

Human Chr (Location): 3q23-q24; chr3:149517235-149703273 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(8) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null mutation display polycystic kidneys, elevated blood urea nitrogen, partial postnatal lethality, premature death, reduced litter sizes, and mildly reduced body size.
 
Human Diseases Modeled in Mice Using Wwtr1 (2)    Mutations Annotated to Human Diseases (2)    Phenotype Images(6)
Interactions
Wwtr1 interacts with 350 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process cilium morphogenesis, glomerulus development, ...
Component cytoplasm, nucleoplasm, ...
Function protein binding, protein homodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (114)    Tissues (35)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 112
RT-PCR 2
cDNA source data(101)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase wwtr1    NEW 
Molecular
reagents
All nucleic(102) cDNA(101) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000029047 (Evidence)
Ensembl Gene Model ENSMUSG00000027803 (Evidence)
Entrez Gene 97064 (Evidence)
UniGene 405029
DFCI TC1576108, TC1649923
DoTS DT.94155092, DT.101296818, DT.530148
NIA Mouse Gene Index U024068
Consensus CDS Project CCDS38434.1, CCDS50912.1
International Mouse Phenotyping Consortium Status Wwtr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029047 VEGA Gene Model | MGI Sequence Detail 120262 C57BL/6J ±  kb
transcript OTTMUST00000072074 VEGA | MGI Sequence Detail 4533 Not Applicable 
polypeptide OTTMUSP00000037016 VEGA | MGI Sequence Detail 452 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(963 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001202 WW domain
Protein Ontology PR:000017466 WW domain-containing transcription regulator protein 1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:218609 Serinagaoglu Y, et al., Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Dev Biol. 2015 Feb 1;398(1):97-109
All references(68)
Disease annotation references (3)
Other
accession IDs
MGI:1917177, MGI:2140055

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory