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Fndc5
Gene Detail
Symbol

Name
ID
Fndc5
fibronectin type III domain containing 5
MGI:1917614
Synonyms
1500001L03Rik, PeP, Pxp
Feature Type
protein coding gene
Genetic Map
Chromosome 4
62.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:129136999-129144593 bp, + strand
From VEGA annotation of GRCm38

  7595 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17812  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: FNDC5
Gene Tree: Fndc5

Human
homologs
FNDC5, fibronectin type III domain containing 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 252995
neXtProt AC: NX_Q8NAU1

Human Synonyms: FRCP2, irisin

Human Chr (Location): 1p35.1; chr1:32862268-32872492 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Genomic Mutations involving Fndc5 (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Fndc5 interacts with 276 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (60)    Tissues (38)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Northern blot 36
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) cDNA(31) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000009621 (Evidence)
Ensembl Gene Model ENSMUSG00000001334 (Evidence)
Entrez Gene 384061 (Evidence)
UniGene 44075
DFCI TC1580747
DoTS DT.490810, DT.523370
NIA Mouse Gene Index U040627
Consensus CDS Project CCDS18683.1
International Mouse Phenotyping Consortium Status Fndc5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009621 VEGA Gene Model | MGI Sequence Detail 7595 C57BL/6J ±  kb
transcript OTTMUST00000022138 VEGA | MGI Sequence Detail 2763 Not Applicable 
polypeptide OTTMUSP00000010089 VEGA | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000030681 fibronectin type III domain-containing protein 5
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:194162 Hashemi MS, et al., Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells. Neuroscience. 2013 Feb 12;231:296-304
All references(34)
Other
accession IDs
MGI:2140366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory