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Fndc5 Gene Detail
Summary
  • Symbol
    Fndc5
  • Name
    fibronectin type III domain containing 5
  • Synonyms
    1500001L03Rik, PeP, Pxp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917614
    NCBI Gene: 384061
  • Gene Overview
    MyGene.info: FNDC5
Location & Maps
more
  • Sequence Map
    Chr4:129136999-129144593 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7595 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 62.93 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FNDC5, fibronectin type III domain containing 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FNDC5, fibronectin type III domain containing 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FRCP2, irisin
  • Links
    NCBI Gene ID: 252995
    neXtProt AC: NX_Q8NAU1

  • Chr Location
    1p35.1; chr1:32862268-32872492 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    4 involving Fndc5
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009621 VEGA Gene Model | MGI Sequence Detail 7595 C57BL/6J ±  kb
transcript OTTMUST00000022138 VEGA | MGI Sequence Detail 2763 Not Applicable  
polypeptide OTTMUSP00000010089 VEGA | MGI Sequence Detail 209 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    102 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000030681 fibronectin type III domain-containing protein 5
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR032073 Fibronectin type III domain-containing protein 5, C-terminal domain
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
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  • All nucleic 32
    cDNA 31
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140366
References
more
  • Summaries
    All 31
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:194162 Hashemi MS, et al., Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells. Neuroscience. 2013 Feb 12;231:296-304

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory