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Fndc5 Gene Detail
Summary
  • Symbol
    Fndc5
  • Name
    fibronectin type III domain containing 5
  • Synonyms
    1500001L03Rik, PeP, Pxp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917614
    NCBI Gene: 384061
  • Gene Overview
    MyGene.info: FNDC5
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:129136999-129144593 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 62.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917614
protein coding gene Chr4:129136921-129144593 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028814
protein coding gene Chr4:130994540-131003821 (+)
A/J MGP_AJ_G0028773
protein coding gene Chr4:125810647-125818220 (+)
AKR/J MGP_AKRJ_G0028726
protein coding gene Chr4:129299185-129306807 (+)
BALB/cJ MGP_BALBcJ_G0028796
protein coding gene Chr4:126389235-126396821 (+)
C3H/HeJ MGP_C3HHeJ_G0028510
protein coding gene Chr4:129348049-129355627 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029238
protein coding gene Chr4:135958670-135966234 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026511
protein coding gene Chr4:118937686-118945386 (+)
CAST/EiJ MGP_CASTEiJ_G0027943
protein coding gene Chr4:127525505-127533236 (+)
CBA/J MGP_CBAJ_G0028476
protein coding gene Chr4:139279885-139287485 (+)
DBA/2J MGP_DBA2J_G0028625
protein coding gene Chr4:126237007-126244596 (+)
FVB/NJ MGP_FVBNJ_G0028592
protein coding gene Chr4:124994356-125001937 (+)
LP/J MGP_LPJ_G0028726
protein coding gene Chr4:131308431-131316039 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028618
protein coding gene Chr4:144181575-144189163 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029276
protein coding gene Chr4:129668445-129676038 (+)
PWK/PhJ MGP_PWKPhJ_G0027664
protein coding gene Chr4:122811642-122820739 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027491
protein coding gene Chr4:125523714-125531350 (+)
WSB/EiJ MGP_WSBEiJ_G0028023
protein coding gene Chr4:129777393-129784997 (+)



Homology
more
  • Human Ortholog
    FNDC5, fibronectin type III domain containing 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FNDC5, fibronectin type III domain containing 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FRCP2, irisin
  • Links
    NCBI Gene ID: 252995
    neXtProt AC: NX_Q8NAU1
    UniProt: Q8NAU1

  • Chr Location
    1p35.1; chr1:32862268-32872492 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    4 involving Fndc5
  • Incidental Mutations
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001334 Ensembl Gene Model | MGI Sequence Detail 7595 C57BL/6J ±  kb
transcript ENSMUST00000102600 Ensembl | MGI Sequence Detail 2763 Not Applicable  
polypeptide ENSMUSP00000099660 Ensembl | MGI Sequence Detail 209 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
less
  • All nucleic 33
    cDNA 32
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140366
References
more
  • Summaries
    All 45
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:245085 Natalicchio A, et al., The Myokine Irisin Is Released in Response to Saturated Fatty Acids and Promotes Pancreatic beta-Cell Survival and Insulin Secretion. Diabetes. 2017 Nov;66(11):2849-2856

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory