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Fndc5
Gene Detail
 Symbol
Name
ID
Fndc5
fibronectin type III domain containing 5
MGI:1917614
Synonyms 1500001L03Rik, PeP, Pxp
Feature Type protein coding gene
Genetic Map
Chromosome 4
62.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:129136999-129144593 bp, + strand
From VEGA annotation of GRCm38

  7595 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:17812  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Fndc5

Human
homologs
Human Homolog FNDC5, fibronectin type III domain containing 5
NCBI Gene ID 252995
neXtProt AC  NX_Q8NAU1
Human Synonyms  FRCP2, irisin
Human Chr (Location)  1p35.1; chr1:32862268-32872492 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Gene trapped(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Fndc5 interacts with 277 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process positive regulation of brown fat cell differentiation, response to muscle activity
Component endoplasmic reticulum, extracellular region, ...
Function hormone activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (60)    Tissues (38)    Images (10)
Theiler Stages: 10, 15, 17, 18, 19, 21, 23, 25, 27, 28
Assay TypeResults
RNA in situ 24
Northern blot 36
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) cDNA(31) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000009621 (Evidence)
Ensembl Gene ModelENSMUSG00000001334 (Evidence)
Entrez Gene384061 (Evidence)
UniGene44075
DFCITC1580747
DoTSDT.490810, DT.523370
NIA Mouse Gene IndexU040627
Consensus CDS ProjectCCDS18683.1
International Mouse Knockout Project StatusFndc5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009621 VEGA Gene Model | MGI Sequence Detail 7595 C57BL/6J ±  kb
transcript OTTMUST00000022138 VEGA | MGI Sequence Detail 2763 Not Applicable 
polypeptide OTTMUSP00000010089 VEGA | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000030681 fibronectin type III domain-containing protein 5
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:194162 Hashemi MS, et al., Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells. Neuroscience. 2013 Feb 12;231:296-304
All references(35)
Other
accession IDs
MGI:2140366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory