About   Help   FAQ
Pggt1b Gene Detail
Summary
  • Symbol
    Pggt1b
  • Name
    protein geranylgeranyltransferase type I, beta subunit
  • Synonyms
    2010207C17Rik, BGG1, GGT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917514
    NCBI Gene: 225467
Location & Maps
more
  • Sequence Map
    Chr18:46239949-46280850 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40902 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 24.45 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PGGT1B, protein geranylgeranyltransferase type I subunit beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PGGT1B, protein geranylgeranyltransferase type I subunit beta
    Orthology source: HomoloGene
  • Synonyms
    BGGI, GGTI
  • Links
    NCBI Gene ID: 5229
    neXtProt AC: NX_P53609

  • Chr Location
    5q22.3; chr5:115200241-115262887 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Gene trapped
    23
  • Targeted
    4
  • Incidental Mutations
Homozygous inactivation of this gene blocks proliferation of primary mouse fibroblasts, disrupts the actin cytoskeleton, and results in altered cell morphology and reduced cell migration in a standard wound healing assay.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024477 Ensembl Gene Model | MGI Sequence Detail 40902 C57BL/6J ±  kb
transcript ENSMUST00000025354 Ensembl | MGI Sequence Detail 2736 Not Applicable  
polypeptide ENSMUSP00000025354 Ensembl | MGI Sequence Detail 377 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    222 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000012606 geranylgeranyl transferase type-1 subunit beta
  • EC
  • InterPro Domains
    IPR001330 PFTB repeat
    IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Molecular
Reagents
less
  • All nucleic 20
    cDNA 20

    Microarray probesets 9
Other
Accession IDs
less
MGI:2143611, MGI:2147241
References
more
  • Summaries
    All 41
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:231157 Lopez-Posadas R, et al., Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation. J Clin Invest. 2016 Feb 1;126(2):611-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory