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Pggt1b Gene Detail
Summary
  • Symbol
    Pggt1b
  • Name
    protein geranylgeranyltransferase type I, beta subunit
  • Synonyms
    2010207C17Rik, BGG1, GGT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917514
    NCBI Gene: 225467
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:46239949-46280850 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 24.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    222 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917514
protein coding gene Chr18:46235344-46281090 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024405
protein coding gene Chr18:45028963-45076203 (-)
A/J MGP_AJ_G0024372
protein coding gene Chr18:43402770-43445981 (-)
AKR/J MGP_AKRJ_G0024341
protein coding gene Chr18:44598933-44645664 (-)
BALB/cJ MGP_BALBcJ_G0024372
protein coding gene Chr18:43518209-43560611 (-)
C3H/HeJ MGP_C3HHeJ_G0024139
protein coding gene Chr18:44684338-44728787 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024816
protein coding gene Chr18:46604813-46650099 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022251
protein coding gene Chr18:43254497-43295155 (-)
CAST/EiJ MGP_CASTEiJ_G0023613
protein coding gene Chr18:44649106-44692082 (-)
CBA/J MGP_CBAJ_G0024108
protein coding gene Chr18:47858931-47903119 (-)
DBA/2J MGP_DBA2J_G0024238
protein coding gene Chr18:43031000-43073072 (-)
FVB/NJ MGP_FVBNJ_G0024204
protein coding gene Chr18:42597184-42638284 (-)
LP/J MGP_LPJ_G0024322
protein coding gene Chr18:45081244-45133612 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024235
protein coding gene Chr18:49224130-49273215 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024863
protein coding gene Chr18:44513955-44558184 (-)
PWK/PhJ MGP_PWKPhJ_G0023357
protein coding gene Chr18:43162163-43204886 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023162
protein coding gene Chr18:44675392-44720098 (-)
WSB/EiJ MGP_WSBEiJ_G0023676
protein coding gene Chr18:44408626-44456838 (-)



Homology
more
  • Human Ortholog
    PGGT1B, protein geranylgeranyltransferase type I subunit beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PGGT1B, protein geranylgeranyltransferase type I subunit beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BGGI, GGTI
  • Links
    NCBI Gene ID: 5229
    neXtProt AC: NX_P53609
    UniProt: P53609

  • Chr Location
    5q22.3; chr5:115200247-115262887 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene blocks proliferation of primary mouse fibroblasts, disrupts the actin cytoskeleton, and results in altered cell morphology and reduced cell migration in a standard wound healing assay.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024477 Ensembl Gene Model | MGI Sequence Detail 40902 C57BL/6J ±  kb
transcript ENSMUST00000025354 Ensembl | MGI Sequence Detail 2736 Not Applicable  
polypeptide ENSMUSP00000025354 Ensembl | MGI Sequence Detail 377 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 21
    cDNA 21

    Microarray probesets 9
Other
Accession IDs
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MGI:2143611, MGI:2147241
References
more
  • Summaries
    All 47
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:258088 Hottman D, et al., Systemic or Forebrain Neuron-Specific Deficiency of Geranylgeranyltransferase-1 Impairs Synaptic Plasticity and Reduces Dendritic Spine Density. Neuroscience. 2018 Mar 1;373:207-217

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory