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Med30
Gene Detail
Symbol

Name
ID
Med30
mediator complex subunit 30
MGI:1917040
Synonyms
1810038N03Rik, 2510044J04Rik, Thrap6, Trap25
Feature Type
protein coding gene
Genetic Map
Chromosome 15
19.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:52712445-52730431 bp, + strand
From NCBI annotation of GRCm38

  17987 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12329  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Med30

Human
homologs
Human Homolog MED30, mediator complex subunit 30
NCBI Gene ID 90390
neXtProt AC  NX_Q96HR3
Human Synonyms  MED30S, THRAP6, TRAP25
Human Chr (Location)  8q24.11; chr8:117520713-117540262 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Chemically induced (ENU)(1) Gene trapped(2)
Incidental mutations (data from APF )
 
Mice homozygous for an ENU-induced allele exhibit premature death associated with cachexia and a rapidly progressive cardiomyopathy.
 
Interactions
Med30 interacts with 43 markers (Mir16-1, Mir20a, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process androgen receptor signaling pathway, intracellular steroid hormone receptor signaling pathway, ...
Component mediator complex, nucleus
Function protein binding, receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(48)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000038622 (Evidence)
Entrez Gene69790 (Evidence)
UniGene195562
DFCITC1579779
DoTSDT.492686
NIA Mouse Gene IndexU016244
Consensus CDS ProjectCCDS27465.1
International Mouse Knockout Project StatusMed30
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 69790 NCBI Gene Model | MGI Sequence Detail 17987 C57BL/6J ±  kb
transcript NM_027212 RefSeq | MGI Sequence Detail 871 C57BL/6 
polypeptide Q9CQI9 UniProt | EBI | MGI Sequence Detail 178 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(144 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021019 Mediator complex, subunit Med30, metazoa
Protein Ontology PR:000010302 mediator of RNA polymerase II transcription subunit 30
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:180447 Krebs P, et al., Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet. Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19678-82
All references(36)
Other
accession IDs
MGI:1917553

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory