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Med30 Gene Detail
Summary
  • Symbol
    Med30
  • Name
    mediator complex subunit 30
  • Synonyms
    1810038N03Rik, 2510044J04Rik, Thrap6, Trap25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917040
    NCBI Gene: 69790
  • Gene Overview
    MyGene.info: MED30
Location & Maps
more
  • Sequence Map
    Chr15:52712445-52730431 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17987 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 19.95 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    MED30, mediator complex subunit 30
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MED30, mediator complex subunit 30
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MED30S, THRAP6, TRAP25
  • Links
    NCBI Gene ID: 90390
    neXtProt AC: NX_Q96HR3

  • Chr Location
    8q24.11; chr8:117520713-117540262 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 12329
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MED30
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Radiation induced
    1
  • Genomic Mutations
    3 involving Med30
  • Incidental Mutations
    APF
Mice homozygous for an ENU-induced allele exhibit premature death associated with cachexia and a rapidly progressive cardiomyopathy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69790 NCBI Gene Model | MGI Sequence Detail 17987 C57BL/6J ±  kb
transcript NM_027212 RefSeq | MGI Sequence Detail 871 C57BL/6  
polypeptide Q9CQI9 UniProt | EBI | MGI Sequence Detail 178 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    144 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010302 mediator of RNA polymerase II transcription subunit 30
  • InterPro Domains
    IPR021019 Mediator complex, subunit Med30, metazoa
Molecular
Reagents
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  • All nucleic 48
    cDNA 48

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917553
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory