About   Help   FAQ
Med30
Gene Detail
Symbol

Name
ID
Med30
mediator complex subunit 30
MGI:1917040
Synonyms
1810038N03Rik, 2510044J04Rik, Thrap6, Trap25
Feature Type
protein coding gene
Genetic Map
Chromosome 15
19.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:52712445-52730431 bp, + strand
From NCBI annotation of GRCm38

  17987 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12329  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MED30
Gene Tree: Med30

Human
homologs
MED30, mediator complex subunit 30
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 90390
neXtProt AC: NX_Q96HR3

Human Synonyms: MED30S, THRAP6, TRAP25

Human Chr (Location): 8q24.11; chr8:117520713-117540262 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Chemically induced (ENU)(1) Gene trapped(2)
Incidental mutations (data from APF )
 
Mice homozygous for an ENU-induced allele exhibit premature death associated with cachexia and a rapidly progressive cardiomyopathy.
 
Interactions
Med30 interacts with 43 markers (Mir16-1, Mir20a, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process androgen receptor signaling pathway, intracellular steroid hormone receptor signaling pathway, ...
Component mediator complex, nucleus, ...
Function protein binding, receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
cDNA source data(48)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase med30 ; ZFIN med30    NEW 
Molecular
reagents
All nucleic(48) cDNA(48)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000038622 (Evidence)
Entrez Gene 69790 (Evidence)
UniGene 195562
DFCI TC1579779
DoTS DT.492686
NIA Mouse Gene Index U016244
Consensus CDS Project CCDS27465.1
International Mouse Phenotyping Consortium Status Med30
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 69790 NCBI Gene Model | MGI Sequence Detail 17987 C57BL/6J ±  kb
transcript NM_027212 RefSeq | MGI Sequence Detail 871 C57BL/6 
polypeptide Q9CQI9 UniProt | EBI | MGI Sequence Detail 178 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(144 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021019 Mediator complex, subunit Med30, metazoa
Protein Ontology PR:000010302 mediator of RNA polymerase II transcription subunit 30
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:215933 Tsai KL, et al., Subunit architecture and functional modular rearrangements of the transcriptional mediator complex. Cell. 2014 Jun 5;157(6):1430-44
All references(36)
Other
accession IDs
MGI:1917553

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory