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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Med30
mediator complex subunit 30
MGI:1917040
33 phenotypes from 3 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Med30Gt(CH0776)Wtsi/Med30m1Btlr
involves: 129P2/OlaHsd * C57BL/6J 		preweaning lethality, complete penetrance J:180447
Med30m1Btlr/Med30m1Btlr
involves: C57BL/6J 		abnormal I band morphology J:180728
abnormal mitochondrial morphology J:180728
abnormal mitochondrial physiology J:180728
abnormal myocardial fiber morphology J:180728
abnormal sarcomere morphology J:180728
abnormal Z line morphology J:180728
anemia J:180728
cachexia J:180728
cardiac fibrosis J:180728
cardiomyopathy J:180728
congestive heart failure J:180728
decreased cardiac muscle contractility J:180728
increased erythroid progenitor cell number J:180728
internal hemorrhage J:180728
myocardium necrosis J:180728
premature death J:180728
Med30tm1.1Sev/Med30tm1.1Sev
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		no abnormal phenotype detected J:309620
Med30tm1.1Sev/Med30tm1.1Sev
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL 		cardiac fibrosis J:309620
congestive heart failure J:309620
decreased heart left ventricle muscle contractility J:309620
decreased heart left ventricle posterior wall thickness J:309620
decreased protein level J:309620
dilated cardiomyopathy J:309620
dilated heart left ventricle J:309620
dilated heart ventricle J:309620
increased myocardial fiber apoptosis J:309620
premature death J:309620
thin ventricular wall J:309620
Med30tm1.1Sev/Med30tm1.1Sev
Tg(Tnnt2-cre)5Blh/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 * SJL 		abnormal heart development J:309620
decreased fetal cardiomyocyte proliferation J:309620
decreased protein level J:309620
embryonic lethality during organogenesis, complete penetrance J:309620
internal hemorrhage J:309620
pleural effusion J:309620
small heart J:309620
thin left ventricle myocardium compact layer J:309620
thin right ventricle myocardium compact layer J:309620
thin ventricular wall J:309620
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory