Med30^tm1.1Sev
Targeted Allele Detail

Summary

• Symbol: Med30^tm1.1Sev
• Name: mediator complex subunit 30; targeted mutation 1.1, Sylvia Evans
• MGI ID: MGI:7314487
• Synonyms: Med30^flox
• Gene: Med30 Location: Chr15:52575841-52593827 bp, + strand Genetic Position: Chr15, 19.95 cM
• Alliance: Med30^tm1.1Sev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309620
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 1 and an FRT-flanked neomycin resistance cassette with a 3 loxP site. Flp-mediated recombination removed the selection cassette and left exon 1 floxed. (J:309620)

Expression

In Mice Carrying this Mutation:

82 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Med30 Mutation: 9 strains or lines available

References

• Original: J:309620 Tan C, et al., Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network. PLoS Genet. 2021 Sep;17(9):e1009785
• All: 1 reference(s)