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Tnfaip8l2 Gene Detail
Summary
  • Symbol
    Tnfaip8l2
  • Name
    tumor necrosis factor, alpha-induced protein 8-like 2
  • Synonyms
    1810019A08Rik, Tipe2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917019
    NCBI Gene: 69769
  • Gene Overview
    MyGene.info: TNFAIP8L2
Location & Maps
more
  • Sequence Map
    Chr3:95139521-95142360 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2840 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TNFAIP8L2, TNF alpha induced protein 8 like 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TNFAIP8L2, TNF alpha induced protein 8 like 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TIPE2
  • Links
    NCBI Gene ID: 79626
    neXtProt AC: NX_Q6P589

  • Chr Location
    1q21.3; chr1:151156629-151159749 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Tnfaip8l2
  • Incidental Mutations
    APF
About 50% of mice homozygous for a null allele die prematurely of a chronic disease characterized by weight loss, splenomegaly, leukocytosis, and multiorgan inflammation; mutants are hypersensitive to septic shock while cells are hyperresponsive to Toll-like receptor and T cell receptor activation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022314 VEGA Gene Model | MGI Sequence Detail 2840 C57BL/6J ±  kb
transcript OTTMUST00000053173 VEGA | MGI Sequence Detail 1122 Not Applicable  
polypeptide OTTMUSP00000025271 VEGA | MGI Sequence Detail 184 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    52 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000016478 tumor necrosis factor alpha-induced protein 8-like protein 2
  • InterPro Domains
    IPR008477 Protein of unknown function DUF758
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 3
Other
Accession IDs
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MGI:2140012
References
more
  • Summaries
    All 35
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:223252 Zhang W, et al., TIPE2 protein negatively regulates HBV-specific CD8(+) T lymphocyte functions in humans. Mol Immunol. 2015 Mar;64(1):204-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory