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Tnfaip8l2 Gene Detail
Summary
  • Symbol
    Tnfaip8l2
  • Name
    tumor necrosis factor, alpha-induced protein 8-like 2
  • Synonyms
    1810019A08Rik, Tipe2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917019
    NCBI Gene: 69769
  • Gene Overview
    MyGene.info: TNFAIP8L2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:95139521-95142360 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917019
protein coding gene Chr3:95139521-95142416 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027572
protein coding gene Chr3:95834270-95837109 (-)
A/J MGP_AJ_G0027531
protein coding gene Chr3:92880617-92883459 (-)
AKR/J MGP_AKRJ_G0027498
protein coding gene Chr3:95023494-95026336 (-)
BALB/cJ MGP_BALBcJ_G0027543
protein coding gene Chr3:92649997-92652839 (-)
C3H/HeJ MGP_C3HHeJ_G0027276
protein coding gene Chr3:95302965-95305807 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027991
protein coding gene Chr3:99401719-99404558 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025331
protein coding gene Chr3:89239925-89242766 (-)
CAST/EiJ MGP_CASTEiJ_G0026726
protein coding gene Chr3:94587422-94590252 (-)
CBA/J MGP_CBAJ_G0027253
protein coding gene Chr3:103006852-103009694 (-)
DBA/2J MGP_DBA2J_G0027392
protein coding gene Chr3:92173024-92175866 (-)
FVB/NJ MGP_FVBNJ_G0027363
protein coding gene Chr3:90241121-90243963 (-)
LP/J MGP_LPJ_G0027501
protein coding gene Chr3:97130415-97133254 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027390
protein coding gene Chr3:109132735-109135574 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028045
protein coding gene Chr3:94678108-94680950 (-)
PWK/PhJ MGP_PWKPhJ_G0026454
protein coding gene Chr3:92047676-92050521 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026275
protein coding gene Chr3:92971793-92974631 (-)
WSB/EiJ MGP_WSBEiJ_G0026808
protein coding gene Chr3:95060972-95063813 (-)



Homology
more
  • Human Ortholog
    TNFAIP8L2, TNF alpha induced protein 8 like 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TNFAIP8L2, TNF alpha induced protein 8 like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TIPE2
  • Links
    NCBI Gene ID: 79626
    neXtProt AC: NX_Q6P589
    UniProt: Q6P589

  • Chr Location
    1q21.3; chr1:151156629-151159749 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 1 allele in 1 genetic background
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
About 50% of mice homozygous for a null allele die prematurely of a chronic disease characterized by weight loss, splenomegaly, leukocytosis, and multiorgan inflammation; mutants are hypersensitive to septic shock while cells are hyperresponsive to Toll-like receptor and T cell receptor activation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000013707 Ensembl Gene Model | MGI Sequence Detail 2840 C57BL/6J ±  kb
    transcript ENSMUST00000013851 Ensembl | MGI Sequence Detail 1122 Not Applicable  
    polypeptide ENSMUSP00000013851 Ensembl | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000016478 tumor necrosis factor alpha-induced protein 8-like protein 2
    • InterPro Domains
      IPR038355 TNFAIP8 superfamily
      IPR008477 Tumor necrosis factor alpha-induced protein 8-like
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2140012
    References
    more
    • Summaries
      All 51
      Diseases 1
      Gene Ontology 7
      Phenotypes 24
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:294584 Yan D, et al., TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis. J Exp Med. 2020 Feb 3;217(2)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/10/2020
    MGI 6.16
    The Jackson Laboratory