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Tnfaip8l2
Gene Detail
 Symbol
Name
ID
Tnfaip8l2
tumor necrosis factor, alpha-induced protein 8-like 2
MGI:1917019
Synonyms 1810019A08Rik, Tipe2
Feature Type protein coding gene
Genetic Map
Chromosome 3
40.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:95139521-95142360 bp, - strand
From VEGA annotation of GRCm38

  2840 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56998  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Tnfaip8l2

Human
homologs
Human Homolog TNFAIP8L2, tumor necrosis factor, alpha-induced protein 8-like 2
NCBI Gene ID 79626
neXtProt AC  NX_Q6P589
Human Synonyms  TIPE2
Human Chr (Location)  1q21.3; chr1:151156629-151159749 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from APF )
 
About 50% of mice homozygous for a null allele die prematurely of a chronic disease characterized by weight loss, splenomegaly, leukocytosis, and multiorgan inflammation; mutants are hypersensitive to septic shock while cells are hyperresponsive to Toll-like receptor and T cell receptor activation.
 
Interactions
Tnfaip8l2 interacts with 60 markers (Mir29b-2, Mir30a, Mir30c-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process immune system process, innate immune response, ...
Component cytoplasm
Function protein binding
External Resources: FuncBase
Expression
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022314 (Evidence)
Ensembl Gene ModelENSMUSG00000013707 (Evidence)
Entrez Gene69769 (Evidence)
UniGene34368
DFCITC1582981
DoTSDT.489215
Consensus CDS ProjectCCDS17603.1
International Mouse Knockout Project StatusTnfaip8l2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022314 VEGA Gene Model | MGI Sequence Detail 2840 C57BL/6J ±  kb
transcript OTTMUST00000053173 VEGA | MGI Sequence Detail 1122 Not Applicable 
polypeptide OTTMUSP00000025271 VEGA | MGI Sequence Detail 184 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008477 Protein of unknown function DUF758
Protein Ontology PR:000016478 tumor necrosis factor alpha-induced protein 8-like protein 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206231 Lou Y, et al., Enhanced atherosclerosis in TIPE2-deficient mice is associated with increased macrophage responses to oxidized low-density lipoprotein. J Immunol. 2013 Nov 1;191(9):4849-57
All references(36)
Other
accession IDs
MGI:2140012

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory