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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tnfaip8l2
tumor necrosis factor, alpha-induced protein 8-like 2
MGI:1917019
38 phenotypes from 1 allele in 1 genetic background
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tnfaip8l2tm1Yhcn/Tnfaip8l2tm1Yhcn
129S6/SvEvTac-Tnfaip8l2tm1Yhcn 		abnormal B cell activation J:139785
abnormal B cell physiology J:139785
abnormal CD4-positive, alpha-beta T cell physiology J:139785
abnormal cytotoxic T cell physiology J:139785
abnormal inflammatory response J:139785
abnormal leukocyte morphology J:139785
abnormal macrophage activation involved in immune response J:139785
abnormal myeloid dendritic cell morphology J:139785
abnormal spleen morphology J:139785
abnormal T cell apoptosis J:139785
chronic inflammation J:139785
decreased IgG2a level J:139785
decreased IgG2b level J:139785
decreased survivor rate J:139785
enlarged spleen J:139785
increased B cell number J:139785
increased circulating interleukin-1 beta level J:139785
increased circulating interleukin-6 level J:139785
increased circulating interleukin-10 level J:139785
increased circulating interleukin-12 level J:139785
increased circulating tumor necrosis factor level J:139785
increased interferon-gamma secretion J:139785
increased interleukin-1 beta secretion J:139785
increased interleukin-2 secretion J:139785
increased interleukin-4 secretion J:139785
increased interleukin-6 secretion J:139785
increased interleukin-12 secretion J:139785
increased interleukin-17 secretion J:139785
increased spleen white pulp amount J:139785
increased susceptibility to endotoxin shock J:139785
increased T cell number J:139785
increased tumor necrosis factor secretion J:139785
intestinal inflammation J:139785
liver inflammation J:139785
lung inflammation J:139785
lymph node inflammation J:139785
spleen hyperplasia J:139785
weight loss J:139785
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory