Fbxo7
Gene Detail

Symbol Name ID

Fbxo7 F-box protein 7 MGI:1917004

Synonyms

2410015K21Rik, A230052G17Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 10

41.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:86021972-86051873 bp, + strand From VEGA annotation of GRCm38   29902 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8136  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fbxo7

Human homologs

Human Homolog		FBXO7, F-box protein 7
NCBI Gene ID		25793
neXtProt AC		NX_Q9Y3I1
Human Synonyms		FBX, FBX07, FBX7, PARK15, PKPS
Human Chr (Location)		22q12-q13; chr22:32870707-32894818 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FBXO7

Alleles and phenotypes

All alleles(7) : Targeted(4) Gene trapped(3)
 

Mice homozygous for a knock-out allele exhibit increased pro-B cell numbers and increased erythroid progenitor cell number.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	regulation of protein stability
Component	cytoplasm, nucleus, ...
Function	molecular_function

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (37)    Tissues (5)    Images (24)
Theiler Stages: 23

Assay Type	Results
RNA in situ	37

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) cDNA(18)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000028680 (Evidence)
Ensembl Gene Model	ENSMUSG00000001786 (Evidence)
Entrez Gene	69754 (Evidence)
Consensus CDS Project	CCDS24095.1
International Mouse Knockout Project Status	Fbxo7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028680	VEGA Gene Model | MGI Sequence Detail	29902	C57BL/6J
transcript	OTTMUST00000071033	VEGA | MGI Sequence Detail	5388	Not Applicable
polypeptide	OTTMUSP00000041356	VEGA | MGI Sequence Detail	523	Not Applicable

All sequences(57) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(60 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001810	F-box domain, cyclin-like
InterPro	IPR021625	Proteasome Inhibitor PI31
Protein Ontology	PR:000007419	F-box only protein 7

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:183053 Meziane el K, et al., Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells. J Cell Sci. 2011 Jul 1;124(Pt 13):2175-86
All references(34)

Other accession IDs

MGI:2143525, MGI:2143831, MGI:2143938, MGI:2444955