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Fbxo7
Gene Detail
Symbol

Name
ID
Fbxo7
F-box protein 7
MGI:1917004
Synonyms
2410015K21Rik, A230052G17Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 10
41.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:86021972-86051873 bp, + strand
From VEGA annotation of GRCm38

  29902 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8136  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FBXO7
Gene Tree: Fbxo7

Human
homologs
FBXO7, F-box protein 7
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 25793
neXtProt AC: NX_Q9Y3I1

Human Synonyms: FBX, FBX07, FBX7, PARK15, PKPS

Human Chr (Location): 22q12.3; chr22:32474682-32498831 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FBXO7

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased pro-B cell numbers and increased erythroid progenitor cell number.
 
Interactions
Fbxo7 interacts with 389 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process mitophagy, negative regulation of cyclin-dependent protein serine/threonine kinase activity, ...
Component cytoplasm, cytosol, ...
Function protein kinase binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (37)    Tissues (5)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 37
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fbxo7 ; ZFIN fbxo7    NEW 
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000028680 (Evidence)
Ensembl Gene Model ENSMUSG00000001786 (Evidence)
Entrez Gene 69754 (Evidence)
Consensus CDS Project CCDS24095.1
International Mouse Phenotyping Consortium Status Fbxo7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028680 VEGA Gene Model | MGI Sequence Detail 29902 C57BL/6J ±  kb
transcript OTTMUST00000071033 VEGA | MGI Sequence Detail 5388 Not Applicable 
polypeptide OTTMUSP00000041356 VEGA | MGI Sequence Detail 523 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(122 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001810 F-box domain, cyclin-like
InterPro IPR021625 Proteasome Inhibitor PI31
Protein Ontology PR:000007419 F-box only protein 7
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:183053 Meziane el K, et al., Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells. J Cell Sci. 2011 Jul 1;124(Pt 13):2175-86
All references(32)
Other
accession IDs
MGI:2143525, MGI:2143831, MGI:2143938, MGI:2444955

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory