Fbxo7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Fbxo7
F-box protein 7
MGI:1917004

53 phenotypes from 4 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Fbxo7^{tm1a(EUCOMM)Hmgu}/Fbxo7^{tm1a(EUCOMM)Hmgu} involves: C57BL/6N	abnormal proerythroblast morphology	J:183053
	decreased erythroblast number	J:183053
	increased erythroid progenitor cell number	J:183053
	increased pro-B cell number	J:183053
Fbxo7^{tm1a(EUCOMM)Wtsi}/Fbxo7^{tm1a(EUCOMM)Wtsi} C57BL/6N-Fbxo7^{tm1a(EUCOMM)Wtsi}/Wtsi	decreased circulating fructosamine level	J:211773
	decreased circulating iron level	J:211773
	decreased erythrocyte cell number	J:211773
	decreased hematocrit	J:211773
	decreased hemoglobin content	J:211773
	decreased leukocyte cell number	J:211773
	increased circulating bilirubin level	J:211773
	increased circulating sodium level	J:211773
	increased mean corpuscular hemoglobin	J:211773
	increased red blood cell distribution width	J:211773
	male infertility	J:211773
	thrombocytosis	J:211773
Fbxo7^{tm1a(EUCOMM)Wtsi}/Fbxo7^{tm1a(EUCOMM)Wtsi} involves: C57BL/6N	abnormal effector T cell number	J:272313
	abnormal reticulocyte cell number	J:272313
	abnormal spermatogenesis	J:272313
	abnormal T cell differentiation	J:272313
	anemia	J:272313
	anisocytosis	J:272313
	arrest of spermiogenesis	J:272313
	normal behavior/neurological phenotype	J:272313
	decreased CD4-positive, alpha-beta T cell number	J:272313
	decreased CD8-positive, alpha-beta T cell number	J:272313
	decreased circulating iron level	J:272313
	decreased erythrocyte cell number	J:272313
	decreased hematocrit	J:272313
	decreased hemoglobin content	J:272313
	decreased T cell number	J:272313
	decreased testis weight	J:272313
	enlarged spleen	J:272313
	extramedullary hematopoiesis	J:272313
	hyperchromic macrocytic anemia	J:272313
	immotile sperm	J:272313
	increased activated T cell number	J:272313
	increased circulating bilirubin level	J:272313
	increased double-negative T cell number	J:272313
	increased effector memory CD4-positive, alpha-beta T cell number	J:272313
	increased effector memory CD8-positive, alpha-beta T cell number	J:272313
	increased erythroblast number	J:272313
	increased erythrocyte clearance	J:272313
	increased mean corpuscular hemoglobin concentration	J:272313
	increased mean corpuscular volume	J:272313
	increased memory T cell number	J:272313
	increased red blood cell distribution width	J:272313
	increased spleen weight	J:272313
	increased susceptibility to bacterial infection	J:272313
	increased susceptibility to bacterial infection induced morbidity/mortality	J:272313
	male infertility	J:272313
	normal mortality/aging	J:272313
	oligozoospermia	J:272313
	reticulocytosis	J:272313
	teratozoospermia	J:272313
	thymus atrophy	J:272313
	thymus hypoplasia	J:272313
Fbxo7^{tm1b(EUCOMM)Wtsi}/Fbxo7^{tm1b(EUCOMM)Wtsi} involves: C57BL/6N	postnatal lethality, complete penetrance	J:272313
Fbxo7^{tm1c(EUCOMM)Wtsi}/Fbxo7^{tm1c(EUCOMM)Wtsi} Tg(Cd4-cre)1Cwi/0 involves: C57BL/6J * C57BL/6N	decreased CD8-positive, alpha-beta T cell number	J:272313
	decreased T cell number	J:272313
	normal hematopoietic system phenotype	J:272313
	normal immune system phenotype	J:272313

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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