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Rnaseh2a
Gene Detail
Symbol

Name
ID
Rnaseh2a
ribonuclease H2, large subunit
MGI:1916974
Synonyms
2400006P09Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 8
41.38 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:84956610-84969767 bp, - strand
From VEGA annotation of GRCm38

  13158 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RNASEH2A
Protein SuperFamily: ribonuclease H2, subunit A
Gene Tree: Rnaseh2a

Human
homologs
RNASEH2A, ribonuclease H2, subunit A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10535
neXtProt AC: NX_O75792

Human Synonyms: AGS4, JUNB, RNASEHI, RNHIA, RNHL

Human Chr (Location): 19p13.2; chr19:12802054-12813648 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RNASEH2A

Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(32) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Rnaseh2a interacts with 164 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process DNA replication, removal of RNA primer, mismatch repair, ...
Component nucleus, ribonuclease H2 complex
Function bidentate ribonuclease III activity, endonuclease activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(86)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rnaseh2a ; ZFIN rnaseh2a    NEW 
Molecular
reagents
All nucleic(86) cDNA(86)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000020631 (Evidence)
Ensembl Gene Model ENSMUSG00000052926 (Evidence)
Entrez Gene 69724 (Evidence)
UniGene 182470
DFCI TC1672709, TC1576995
DoTS DT.101402817, DT.55100631, DT.94165162
NIA Mouse Gene Index U278867, U107226
EC 3.1.26.-, 3.1.26.4
PDB 3P5J, 3KIO
Consensus CDS Project CCDS22486.1
International Mouse Phenotyping Consortium Status Rnaseh2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020631 VEGA Gene Model | MGI Sequence Detail 13158 C57BL/6J ±  kb
transcript OTTMUST00000048868 VEGA | MGI Sequence Detail 2981 Not Applicable 
polypeptide OTTMUSP00000022519 VEGA | MGI Sequence Detail 301 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(215 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004649 Ribonuclease H2, subunit A
InterPro IPR023160 Ribonuclease HII, helix-loop-helix cap domain
InterPro IPR001352 Ribonuclease HII/HIII
InterPro IPR024567 Ribonuclease HII/HIII domain
InterPro IPR012337 Ribonuclease H-like domain
Protein Ontology PR:000014054 ribonuclease H2 subunit A
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:198961 Ghodgaonkar MM, et al., Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol Cell. 2013 May 9;50(3):323-32
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory