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Rnaseh2a Gene Detail
Summary
  • Symbol
    Rnaseh2a
  • Name
    ribonuclease H2, large subunit
  • Synonyms
    2400006P09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916974
    NCBI Gene: 69724
  • Gene Overview
    MyGene.info: RNASEH2A
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84956610-84969375 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.38 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    205 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916974
protein coding gene Chr8:84956610-84969767 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033882
protein coding gene Chr8:85899540-85912524 (-)
A/J MGP_AJ_G0033865
protein coding gene Chr8:82503179-82517528 (-)
AKR/J MGP_AKRJ_G0033791
protein coding gene Chr8:84949362-84961286 (-)
BALB/cJ MGP_BALBcJ_G0033858
protein coding gene Chr8:82636465-82649203 (-)
C3H/HeJ MGP_C3HHeJ_G0033568
protein coding gene Chr8:85573053-85588112 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034378
protein coding gene Chr8:89184374-89198474 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031319
protein coding gene Chr8:76301990-76316254 (-)
CAST/EiJ MGP_CASTEiJ_G0032898
protein coding gene Chr8:85007099-85019041 (-)
CBA/J MGP_CBAJ_G0033544
protein coding gene Chr8:92203026-92215950 (-)
DBA/2J MGP_DBA2J_G0033697
protein coding gene Chr8:82143952-82156959 (-)
FVB/NJ MGP_FVBNJ_G0033645
protein coding gene Chr8:81096748-81111608 (-)
LP/J MGP_LPJ_G0033789
protein coding gene Chr8:86002035-86013785 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033687
protein coding gene Chr8:94768117-94790899 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034395
protein coding gene Chr8:84937598-84951164 (-)
PWK/PhJ MGP_PWKPhJ_G0032602
protein coding gene Chr8:81391804-81404050 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032438
protein coding gene Chr8:83750108-83762612 (-)
WSB/EiJ MGP_WSBEiJ_G0033011
protein coding gene Chr8:85370135-85385114 (-)



Homology
more
  • Human Ortholog
    RNASEH2A, ribonuclease H2 subunit A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RNASEH2A, ribonuclease H2 subunit A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGS4, JUNB, RNASEHI, RNHIA, RNHL, THSD8
  • Links
    NCBI Gene ID: 10535
    neXtProt AC: NX_O75792
    UniProt: A0A1W2PP97, O75792

  • Chr Location
    19p13.13; chr19:12802054-12813648 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human RNASEH2A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69724 NCBI Gene Model | MGI Sequence Detail 12766 C57BL/6J ±  kb
transcript NM_027187 RefSeq | MGI Sequence Detail 2109 C57BL/6  
polypeptide Q9CWY8 UniProt | EBI | MGI Sequence Detail 301 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 87
    cDNA 87

    Microarray probesets 3
References
more
  • Summaries
    All 62
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 36
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
  • Latest
    J:266142 Grosjean F, et al., Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice. PLoS One. 2018;13(9):e0204366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory