Rnaseh2a
Gene Detail

Symbol Name ID

Rnaseh2a ribonuclease H2, large subunit MGI:1916974

Synonyms

2400006P09Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 8

41.38 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:84956610-84969767 bp, - strand From VEGA annotation of GRCm38   13158 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: ribonuclease H2, subunit A
Gene Tree: Rnaseh2a

Human homologs

Human Homolog		RNASEH2A, ribonuclease H2, subunit A
NCBI Gene ID		10535
neXtProt AC		NX_O75792
Human Synonyms		AGS4, JUNB, RNASEHI, RNHIA, RNHL
Human Chr (Location)		19p13.2; chr19:12917428-12924462 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RNASEH2A

Alleles and phenotypes

All alleles(35) : Targeted(3) Gene trapped(32)

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	RNA catabolic process, RNA metabolic process
Component	nucleus, ribonuclease H2 complex
Function	endonuclease activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(86)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(86) cDNA(86)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000020631 (Evidence)
Ensembl Gene Model	ENSMUSG00000052926 (Evidence)
Entrez Gene	69724 (Evidence)
UniGene	182470
DFCI	TC1576995, TC1672709
DoTS	DT.101402817, DT.55100631, DT.94165162
NIA Mouse Gene Index	U107226, U278867
EC	3.1.26.-, 3.1.26.4
PDB	3KIO, 3P5J
Consensus CDS Project	CCDS22486.1
International Mouse Knockout Project Status	Rnaseh2a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020631	VEGA Gene Model | MGI Sequence Detail	13158	C57BL/6J
transcript	OTTMUST00000048868	VEGA | MGI Sequence Detail	2981	Not Applicable
polypeptide	OTTMUSP00000022519	VEGA | MGI Sequence Detail	301	Not Applicable

All sequences(56) RefSeq(2) UniProt(5)

Polymorphisms

SNPs within 2kb(215 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR004649	Ribonuclease H2, subunit A
InterPro	IPR023160	Ribonuclease HII, helix-loop-helix cap domain
InterPro	IPR001352	Ribonuclease HII/HIII
InterPro	IPR024567	Ribonuclease HII/HIII domain
InterPro	IPR012337	Ribonuclease H-like domain
Protein Ontology	PR:000014054	ribonuclease H2 subunit A
Protein Ontology	PR:000027793	ribonuclease H2 subunit A (mouse)

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:186180 Reijns MA, et al., Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development. Cell. 2012 May 25;149(5):1008-22
All references(35)