About   Help   FAQ
Rnaseh2a Gene Detail
Summary
  • Symbol
    Rnaseh2a
  • Name
    ribonuclease H2, large subunit
  • Synonyms
    2400006P09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916974
    NCBI Gene: 69724
  • Gene Overview
    MyGene.info: RNASEH2A
Location & Maps
more
  • Sequence Map
    Chr8:84956610-84969767 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13158 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.38 cM, cytoband C3
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RNASEH2A, ribonuclease H2 subunit A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RNASEH2A, ribonuclease H2 subunit A
    Orthology source: HomoloGene
  • Synonyms
    AGS4, JUNB, RNASEHI, RNHIA, RNHL
  • Links
    NCBI Gene ID: 10535
    neXtProt AC: NX_O75792

  • Chr Location
    19p13.2; chr19:12802054-12813648 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RNASEH2A associations

Human Disease Mouse Models
       Aicardi-Goutieres Syndrome 4; AGS4   OMIM: 610333
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotype references
  • All Mutations and Alleles
    37
  • Chemically induced (other)
    1
  • Gene trapped
    32
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Rnaseh2a
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020631 VEGA Gene Model | MGI Sequence Detail 13158 C57BL/6J ±  kb
transcript OTTMUST00000048868 VEGA | MGI Sequence Detail 2981 Not Applicable  
polypeptide OTTMUSP00000022519 VEGA | MGI Sequence Detail 301 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    212 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 86
    cDNA 86

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 35
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:198961 Ghodgaonkar MM, et al., Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol Cell. 2013 May 9;50(3):323-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/24/2016
MGI 6.04
The Jackson Laboratory