Arap1
Gene Detail

Symbol Name ID

Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 MGI:1916960

Synonyms

2410002L19Rik, Centd2, mKIAA0782

Feature Type

protein coding gene

Genetic Map

Chromosome 7

54.56 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:101348067-101412586 bp, + strand From VEGA annotation of GRCm38   64520 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12326  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Arap1

Human homologs

Human Homolog		ARAP1, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
NCBI Gene ID		116985
neXtProt AC		NX_Q96P48
Human Synonyms		CENTD2
Human Chr (Location)		11q13.4; chr11:72396114-72463434 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(28) : Targeted(4) Gene trapped(24)

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	negative regulation of stress fiber assembly, positive regulation of Cdc42 GTPase activity, ...
Component	cytoplasm, cytoplasmic vesicle, ...
Function	ARF GTPase activator activity, GTPase activator activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (20)    Tissues (4)    Images (13)
Theiler Stages: 23

Assay Type	Results
RNA in situ	20

cDNA source data(117)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(118) Genomic(1) cDNA(117)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000026043 (Evidence)
Ensembl Gene Model	ENSMUSG00000032812 (Evidence)
Entrez Gene	69710 (Evidence)
UniGene	277687
DFCI	TC1597253, TC1603102, TC1614405, TC1673497, TC1716529, TC1741941
DoTS	DT.101155528, DT.101397868, DT.101397877, DT.111005117, DT.492554, DT.94231631, DT.99652689
NIA Mouse Gene Index	U008468
Consensus CDS Project	CCDS21510.1, CCDS40041.1, CCDS40042.1
International Mouse Knockout Project Status	Arap1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026043	VEGA Gene Model | MGI Sequence Detail	64520	C57BL/6J
transcript	OTTMUST00000064289	VEGA | MGI Sequence Detail	4926	Not Applicable
polypeptide	OTTMUSP00000031904	VEGA | MGI Sequence Detail	1452	Not Applicable

All sequences(126) RefSeq(8) UniProt(11)

Polymorphisms

SNPs(359 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001164	Arf GTPase activating protein
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR000159	Ras-association
InterPro	IPR000198	Rho GTPase-activating protein domain
InterPro	IPR008936	Rho GTPase activation protein
InterPro	IPR001660	Sterile alpha motif domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR021129	Sterile alpha motif, type 1
InterPro	IPR011510	Sterile alpha motif, type 2
Protein Ontology	PR:000004193	Arf-GAP, Rho-GAP domain, ANK repeat and PH domain-containing protein 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)