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Arap1
Gene Detail
 Symbol
Name
ID
Arap1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
MGI:1916960
Synonyms 2410002L19Rik, Centd2, mKIAA0782
Feature Type protein coding gene
Genetic Map
Chromosome 7
54.56 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:101348067-101412586 bp, + strand
From VEGA annotation of GRCm38

  64520 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12326  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Arap1

Human
homologs
Human Homolog ARAP1, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
NCBI Gene ID 116985
neXtProt AC  NX_Q96P48
Human Synonyms  CENTD2
Human Chr (Location)  11q13.4; chr11:72685069-72752389 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(24) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Arap1 interacts with 223 markers (Mir10a, Mir15a, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process negative regulation of stress fiber assembly, positive regulation of Cdc42 GTPase activity, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function ARF GTPase activator activity, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (20)    Tissues (4)    Images (13)
Theiler Stages: 23
Assay TypeResults
RNA in situ 20
cDNA source data(117)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(118) Genomic(1) cDNA(117)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026043 (Evidence)
Ensembl Gene ModelENSMUSG00000032812 (Evidence)
Entrez Gene69710 (Evidence)
UniGene277687
DFCITC1597253, TC1603102, TC1614405, TC1673497, TC1716529, TC1741941
DoTSDT.101155528, DT.101397868, DT.101397877, DT.111005117, DT.492554, DT.94231631, DT.99652689
NIA Mouse Gene IndexU008468
Consensus CDS ProjectCCDS21510.1, CCDS40041.1, CCDS40042.1
International Mouse Knockout Project StatusArap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026043 VEGA Gene Model | MGI Sequence Detail 64520 C57BL/6J ±  kb
transcript OTTMUST00000064289 VEGA | MGI Sequence Detail 4926 Not Applicable 
polypeptide OTTMUSP00000031904 VEGA | MGI Sequence Detail 1452 Not Applicable 

For the selected sequences
All sequences(148) RefSeq(30) UniProt(11)
Polymorphisms SNPs within 2kb(561 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001164 Arf GTPase activating protein
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000159 Ras-association
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR021129 Sterile alpha motif, type 1
InterPro IPR011510 Sterile alpha motif, type 2
Protein Ontology PR:000004193 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:197767 Hasegawa J, et al., ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5. Mol Biol Cell. 2012 Jul;23(13):2481-9
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory