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Arap1 Gene Detail
Summary
  • Symbol
    Arap1
  • Name
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
  • Synonyms
    2410002L19Rik, Centd2, mKIAA0782
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916960
    NCBI Gene: 69710
  • Alliance
    genome feature page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:100997296-101061793 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.56 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1601 from dbSNP Build 142
  • Strain Annotations
    28
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916960
 protein coding gene Chr7:100997274-101061793 (+)
129S1/SvImJ ENSMUSGG00200054425
 protein coding gene Chr7:87875504-87893710 (+)
129S1/SvImJ ENSMUSGG00200054423
 protein coding gene Chr7:87853811-87854019 (+)
A/J ENSMUSGG00195055505
 protein coding gene Chr7:92359393-92359601 (+)
A/J ENSMUSGG00195055504
 protein coding gene Chr7:92381086-92399294 (+)
AKR/J ENSMUSGG00220054926
 protein coding gene Chr7:85797714-85815921 (+)
AKR/J ENSMUSGG00220054929
 protein coding gene Chr7:85776019-85776227 (+)
BALB/cJ ENSMUSGG00180055503
 protein coding gene Chr7:89032324-89032532 (+)
BALB/cJ ENSMUSGG00180055554
 protein coding gene Chr7:89054020-89072227 (+)
C3H/HeJ ENSMUSGG00175054962
 protein coding gene Chr7:89694559-89694767 (+)
C3H/HeJ ENSMUSGG00175054963
 protein coding gene Chr7:89716274-89734519 (+)
C57BL/6NJ ENSMUSGG00215055317
 protein coding gene Chr7:88890452-88908661 (+)
C57BL/6NJ ENSMUSG00215022112
 protein coding gene Chr7:88881194-88882635 (+)
C57BL/6NJ ENSMUSGG00215055316
 protein coding gene Chr7:88868746-88868954 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030061
 protein coding gene Chr7:104021811-104087506 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054522
 protein coding gene Chr7:89569743-89587988 (+)
CBA/J ENSMUSGG00210055018
 protein coding gene Chr7:89548028-89548236 (+)
DBA/2J ENSMUSGG00185057938
 protein coding gene Chr7:93869693-93869901 (+)
DBA/2J ENSMUSGG00185057937
 protein coding gene Chr7:93891410-93909655 (+)
FVB/NJ ENSMUSGG00205054196
 protein coding gene Chr7:89530540-89530748 (+)
FVB/NJ ENSMUSGG00205054197
 protein coding gene Chr7:89552233-89570440 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055524
 protein coding gene Chr7:99995750-99995958 (+)
LP/J ENSMUSGG00230055526
 protein coding gene Chr7:100017446-100035653 (+)
NOD/ShiLtJ ENSMUSGG00190055045
 protein coding gene Chr7:89832571-89850778 (+)
NOD/ShiLtJ ENSMUSGG00190055058
 protein coding gene Chr7:89810876-89811084 (+)
NZO/HlLtJ ENSMUSGG00225055577
 protein coding gene Chr7:98195402-98213615 (+)
NZO/HlLtJ ENSMUSGG00225055594
 protein coding gene Chr7:98173710-98173918 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010010064
 protein coding gene Chr7:89233536-89298502 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ARAP1, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARAP1, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
  • Synonyms
    CENTD2, cnt-d2
  • Links
    NCBI Gene ID: 116985
    UniProt: Q96P48

  • Chr Location
    11q13.4; chr11:72683204-72793599 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    789
  • Tissues
    49
  • cDNA Data
    117
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69710 NCBI Gene Model | MGI Sequence Detail 64498 C57BL/6J ±  kb
    transcript NM_001407803 RefSeq | MGI Sequence Detail 5850 C57BL/6  
    polypeptide Q4LDD4 UniProt | EBI | MGI Sequence Detail 1452 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 119
      Genomic 2
      cDNA 117

      Microarray probesets 4
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 33
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:363654 Wang J, et al., Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice. J Neurosci. 2025 Feb 26;45(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory