About   Help   FAQ
Arap1 Gene Detail
Summary
  • Symbol
    Arap1
  • Name
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
  • Synonyms
    2410002L19Rik, Centd2, mKIAA0782
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916960
    NCBI Gene: 69710
  • Gene Overview
    MyGene.info: ARAP1
Location & Maps
more
  • Sequence Map
    Chr7:101348067-101412586 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      64520 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.56 cM, cytoband F1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ARAP1, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ARAP1, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CENTD2
  • Links
    NCBI Gene ID: 116985
    neXtProt AC: NX_Q96P48

  • Chr Location
    11q13.4; chr11:72685069-72752389 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    32
  • Chemically induced (other)
    1
  • Gene trapped
    24
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Arap1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026043 VEGA Gene Model | MGI Sequence Detail 64520 C57BL/6J ±  kb
transcript OTTMUST00000064289 VEGA | MGI Sequence Detail 4926 Not Applicable  
polypeptide OTTMUSP00000031904 VEGA | MGI Sequence Detail 1452 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    542 from dbSNP Build 142
Protein
Information
less
  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000004193 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
  • InterPro Domains
    IPR001164 Arf GTPase activating protein
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR000159 Ras-associating (RA) domain
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain
Molecular
Reagents
less
  • All nucleic 118
    Genomic 1
    cDNA 117

    Microarray probesets 4
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 20
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory