Mlip MGI Mouse Gene Detail - MGI:1916892 - muscular LMNA-interacting protein

Symbol

Mlip
Name

muscular LMNA-interacting protein
Synonyms

2310046A06Rik, cardiac ISL1-interacting protein, CIP

Feature Type

protein coding gene
IDs

MGI:1916892
NCBI Gene: 69642
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr9:77009366-77260062 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 42.67 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

1533 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916892	protein coding gene	Chr9:77009363-77260251 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035051	protein coding gene	Chr9:77517449-77781609 (-)
A/J	MGP_AJ_G0035032	protein coding gene	Chr9:74805629-75063564 (-)
AKR/J	MGP_AKRJ_G0034961	protein coding gene	Chr9:76584185-76839292 (-)
BALB/cJ	MGP_BALBcJ_G0035024	protein coding gene	Chr9:74492933-74743732 (-)
C3H/HeJ	MGP_C3HHeJ_G0034733	protein coding gene	Chr9:77086479-77349673 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035542	protein coding gene	Chr9:79580493-79846967 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032453	protein coding gene	Chr9:74081911-74328467 (-)
CAST/EiJ	MGP_CASTEiJ_G0034055	protein coding gene	Chr9:77440847-77700974 (-)
CBA/J	MGP_CBAJ_G0034705	protein coding gene	Chr9:82339592-82628480 (-)
DBA/2J	MGP_DBA2J_G0034865	protein coding gene	Chr9:74470695-74721658 (-)
FVB/NJ	MGP_FVBNJ_G0034807	protein coding gene	Chr9:73734353-73976109 (-)
LP/J	MGP_LPJ_G0034946	protein coding gene	Chr9:77749386-78016115 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034848	protein coding gene	Chr9:83533329-83829439 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035565	protein coding gene	Chr9:76758038-77028907 (-)
PWK/PhJ	MGP_PWKPhJ_G0033759	protein coding gene	Chr9:74726295-74976899 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033592	protein coding gene	Chr9:77021612-77279330 (-)
WSB/EiJ	MGP_WSBEiJ_G0034167	protein coding gene	Chr9:76678482-76937329 (-)

Human Ortholog

MLIP, muscular LMNA interacting protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MLIP, muscular LMNA interacting protein
Synonyms

C6orf142, CIP
Links

HGNC:21355

NCBI Gene ID: 90523

neXtProt AC: NX_Q5VWP3

UniProt: Q5VWP3
Chr Location

6p12.1; chr6:54018916-54266325 (+) GRCh38.p7

Alliance of Genome Resources

Mlip stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MLIP
Gene Tree

Mlip

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
5 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Gene trapped

6
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Mlip
Incidental Mutations

APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display increased cardiac sensitivity to induced stress.

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

672
cDNA Data

12
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mlip

ZFIN mlip

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Mlip interacts with 49 markers (Mir31, Mir32, Mir92-1, ...) View All

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All Sequences

202
RefSeq

139
UniProt

11
CCDS

CCDS52861.1, CCDS90629.1, CCDS90630.1

Ensembl

ENSMUSG00000032355 (Evidence)
NCBI Gene

69642

			Length	Strain/Species	Flank
genomic	69642	NCBI Gene Model \| MGI Sequence Detail	250697	C57BL/6J	± kb
transcript	NM_001368955	RefSeq \| MGI Sequence Detail	3002	C57BL/6
polypeptide	Q5FW52	UniProt \| EBI \| MGI Sequence Detail	269	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000032559 muscular LMNA-interacting protein

(term hierarchy)
InterPro Domains

IPR029331 Muscular LMNA-interacting protein

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All nucleic 12

cDNA 12

Microarray probesets 3

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MGI:2143167

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 14
Earliest

J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
Latest

J:296375 Holmes G, et al., Integrated Transcriptome and Network Analysis Reveals Spatiotemporal Dynamics of Calvarial Suturogenesis. Cell Rep. 2020 Jul 7;32(1):107871

TSS for Mlip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr90605	Chr9:77255171-77255188 (-)	4,882 bp
Tssr90604	Chr9:77255098-77255169 (-)	4,928 bp
Tssr90603	Chr9:77255069-77255097 (-)	4,979 bp
Tssr90602	Chr9:77255050-77255064 (-)	5,005 bp
Tssr90601	Chr9:77231110-77231114 (-)	28,950 bp
Tssr90600	Chr9:77168781-77168789 (-)	91,277 bp
Tssr90599	Chr9:77168744-77168745 (-)	91,317 bp
Tssr90598	Chr9:77168716-77168734 (-)	91,337 bp
Tssr90597	Chr9:77159348-77159358 (-)	100,709 bp
Tssr90596	Chr9:77159153-77159162 (-)	100,904 bp
Tssr90595	Chr9:77159124-77159141 (-)	100,929 bp
Tssr90594	Chr9:77159111-77159120 (-)	100,946 bp
Tssr90593	Chr9:77137745-77137758 (-)	122,310 bp
Tssr90592	Chr9:77137668-77137685 (-)	122,385 bp
Tssr90591	Chr9:77136743-77136753 (-)	123,314 bp
Tssr90590	Chr9:77136710-77136722 (-)	123,346 bp
Tssr90589	Chr9:77130630-77130637 (-)	129,428 bp
Tssr90588	Chr9:77107698-77107702 (-)	152,362 bp
Tssr90587	Chr9:77036101-77036105 (-)	223,959 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/28/2022 MGI 6.20