Mlip Gene Detail

Summary

• Symbol
  Mlip
• Name
  muscular LMNA-interacting protein
• Synonyms
  2310046A06Rik, cardiac ISL1-interacting protein, CIP

• Feature Type
  protein coding gene
• IDs
  MGI:1916892
  NCBI Gene: 69642
• Gene Overview
  MyGene.info: MLIP
• Alliance
  gene page
• Transcription Start Sites
  6 TSS

Location &
Maps

• Sequence Map
  Chr9:77102084-77352781 bp, - strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 9, 42.67 cM, cytoband E1
• Mapping Data
  3 experiments

Strain
Comparison

• SNPs within 2kb
  1539 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916892	protein coding gene	Chr9:77102081-77352969 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035051	protein coding gene	Chr9:77517449-77781609 (-)
A/J	MGP_AJ_G0035032	protein coding gene	Chr9:74805629-75063564 (-)
AKR/J	MGP_AKRJ_G0034961	protein coding gene	Chr9:76584185-76839292 (-)
BALB/cJ	MGP_BALBcJ_G0035024	protein coding gene	Chr9:74492933-74743732 (-)
C3H/HeJ	MGP_C3HHeJ_G0034733	protein coding gene	Chr9:77086479-77349673 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035542	protein coding gene	Chr9:79580493-79846967 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032453	protein coding gene	Chr9:74081911-74328467 (-)
CAST/EiJ	MGP_CASTEiJ_G0034055	protein coding gene	Chr9:77440847-77700974 (-)
CBA/J	MGP_CBAJ_G0034705	protein coding gene	Chr9:82339592-82628480 (-)
DBA/2J	MGP_DBA2J_G0034865	protein coding gene	Chr9:74470695-74721658 (-)
FVB/NJ	MGP_FVBNJ_G0034807	protein coding gene	Chr9:73734353-73976109 (-)
LP/J	MGP_LPJ_G0034946	protein coding gene	Chr9:77749386-78016115 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034848	protein coding gene	Chr9:83533329-83829439 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035565	protein coding gene	Chr9:76758038-77028907 (-)
PWK/PhJ	MGP_PWKPhJ_G0033759	protein coding gene	Chr9:74726295-74976899 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033592	protein coding gene	Chr9:77021612-77279330 (-)
WSB/EiJ	MGP_WSBEiJ_G0034167	protein coding gene	Chr9:76678482-76937329 (-)

Homology

• Human Ortholog
  MLIP, muscular LMNA interacting protein

• Vertebrate Orthologs
  7

• Human Ortholog
  MLIP, muscular LMNA interacting protein
  Orthology source: HomoloGene, HGNC
• Synonyms
  C6orf142, CIP
• Links
  HGNC:21355

  NCBI Gene ID: 90523

  neXtProt AC: NX_Q5VWP3

  UniProt: Q5VWP3

  
  
• Chr Location
  6p12.1; chr6:54018916-54266325 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 90445
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
  
• HCOP
  human homology predictions: MLIP
• Gene Tree
  Mlip
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotypes from 1 allele in 1 genetic background
  5 phenotypes from multigenic genotypes
  11 phenotype references
  

• All Mutations and Alleles
  9
• Chemically induced (other)
  1
• Gene trapped
  6
• Radiation induced
  1
• Targeted
  1
• Genomic Mutations
  2 involving Mlip
• Incidental Mutations
  APF
• Find Mice (IMSR)
  1 strains or lines available

Mice homozygous for a null allele display increased cardiac sensitivity to induced stress.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  11
• GO References
  5

• External Resources
  FuncBase

Expression

• cDNA Data
  12
• Literature Summary
  1

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase mlip
  ZFIN mlip

Interactions

• Mlip interacts with 49 markers (Mir31, Mir32, Mir92-1, ...) View All

Sequences &
Gene Models

• All Sequences
  138
• RefSeq
  75
• UniProt
  11
• CCDS
  CCDS52861.1
• UniGene
  35008

• Ensembl
  ENSMUSG00000032355 (Evidence)
• NCBI Gene
  69642

Representative Sequences			Length	Strain/Species
genomic	69642	NCBI Gene Model | MGI Sequence Detail	250698	C57BL/6J
transcript	NM_027150	RefSeq | MGI Sequence Detail	1224	C57BL/6
polypeptide	Q5FW52	UniProt | EBI | MGI Sequence Detail	269	Not Applicable

Protein
Information

• UniProt
  11 Sequences
• InterPro Domains
  IPR029331 Muscular LMNA-interacting protein

Molecular
Reagents

• All nucleic 12

  cDNA 12

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:2143167

References

• Summaries
  All 34

  Developmental Gene Expression 1

  Gene Ontology 5

  Phenotypes 11
• Earliest
  J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
• Latest
  J:243471 Cattin ME, et al., Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. J Biol Chem. 2015 Oct 30;290(44):26699-714

TSS for Mlip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr90605	Chr9:77347889-77347906 (-)	4,883 bp
Tssr90603	Chr9:77347787-77347815 (-)	4,980 bp
Tssr90602	Chr9:77347768-77347782 (-)	5,006 bp
Tssr90596	Chr9:77251871-77251880 (-)	100,905 bp
Tssr90595	Chr9:77251842-77251859 (-)	100,930 bp
Tssr90594	Chr9:77251829-77251838 (-)	100,947 bp