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Mlip Gene Detail
Summary
  • Symbol
    Mlip
  • Name
    muscular LMNA-interacting protein
  • Synonyms
    2310046A06Rik, cardiac ISL1-interacting protein, CIP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916892
    NCBI Gene: 69642
  • Gene Overview
    MyGene.info: MLIP
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:77102084-77352781 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 42.67 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1539 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916892
protein coding gene Chr9:77102081-77352969 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035051
protein coding gene Chr9:77517449-77781609 (-)
A/J MGP_AJ_G0035032
protein coding gene Chr9:74805629-75063564 (-)
AKR/J MGP_AKRJ_G0034961
protein coding gene Chr9:76584185-76839292 (-)
BALB/cJ MGP_BALBcJ_G0035024
protein coding gene Chr9:74492933-74743732 (-)
C3H/HeJ MGP_C3HHeJ_G0034733
protein coding gene Chr9:77086479-77349673 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035542
protein coding gene Chr9:79580493-79846967 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032453
protein coding gene Chr9:74081911-74328467 (-)
CAST/EiJ MGP_CASTEiJ_G0034055
protein coding gene Chr9:77440847-77700974 (-)
CBA/J MGP_CBAJ_G0034705
protein coding gene Chr9:82339592-82628480 (-)
DBA/2J MGP_DBA2J_G0034865
protein coding gene Chr9:74470695-74721658 (-)
FVB/NJ MGP_FVBNJ_G0034807
protein coding gene Chr9:73734353-73976109 (-)
LP/J MGP_LPJ_G0034946
protein coding gene Chr9:77749386-78016115 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034848
protein coding gene Chr9:83533329-83829439 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035565
protein coding gene Chr9:76758038-77028907 (-)
PWK/PhJ MGP_PWKPhJ_G0033759
protein coding gene Chr9:74726295-74976899 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033592
protein coding gene Chr9:77021612-77279330 (-)
WSB/EiJ MGP_WSBEiJ_G0034167
protein coding gene Chr9:76678482-76937329 (-)



Homology
more
  • Human Ortholog
    MLIP, muscular LMNA interacting protein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MLIP, muscular LMNA interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C6orf142, CIP
  • Links
    NCBI Gene ID: 90523
    neXtProt AC: NX_Q5VWP3
    UniProt: Q5VWP3

  • Chr Location
    6p12.1; chr6:54018916-54266325 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Mlip
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a null allele display increased cardiac sensitivity to induced stress.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69642 NCBI Gene Model | MGI Sequence Detail 250698 C57BL/6J ±  kb
transcript NM_027150 RefSeq | MGI Sequence Detail 1224 C57BL/6  
polypeptide Q5FW52 UniProt | EBI | MGI Sequence Detail 269 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    11 Sequences
  • InterPro Domains
    IPR029331 Muscular LMNA-interacting protein
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143167
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
  • Latest
    J:243471 Cattin ME, et al., Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. J Biol Chem. 2015 Oct 30;290(44):26699-714

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory