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Arhgef12 Gene Detail
Summary
  • Symbol
    Arhgef12
  • Name
    Rho guanine nucleotide exchange factor (GEF) 12
  • Synonyms
    2310014B11Rik, LARG, mKIAA0382
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916882
    NCBI Gene: 69632
  • Gene Overview
    MyGene.info: ARHGEF12
Location & Maps
more
  • Sequence Map
    Chr9:42963842-43105718 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      141877 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.14 cM, cytoband B
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ARHGEF12, Rho guanine nucleotide exchange factor 12
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ARHGEF12, Rho guanine nucleotide exchange factor 12
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LARG, PRO2792
  • Links
    NCBI Gene ID: 23365
    neXtProt AC: NX_Q9NZN5

  • Chr Location
    11q23.3; chr11:120336406-120489936 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    2 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased sensitivity to certain vasoconstrictors and resistance to salt-induced hypertension. Mice homozygous for a different knock-out allele exhibit partial prenatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69632 NCBI Gene Model | MGI Sequence Detail 141877 C57BL/6J ±  kb
transcript NM_027144 RefSeq | MGI Sequence Detail 10483 Not Specified  
polypeptide Q8R4H2 UniProt | EBI | MGI Sequence Detail 1543 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    633 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000004249 rho guanine nucleotide exchange factor 12
  • InterPro Domains
    IPR000219 Dbl homology (DH) domain
    IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
    IPR001478 PDZ domain
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR015212 Regulator of G protein signalling-like domain
    IPR016137 RGS domain
Molecular
Reagents
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  • All nucleic 14
    cDNA 14

    Microarray probesets 6
Other
Accession IDs
less
MGI:2143206
References
more
  • Summaries
    All 51
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:222734 Mikelis CM, et al., RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nat Commun. 2015;6:6725

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory