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Arhgef12
Gene Detail
Symbol

Name
ID
Arhgef12
Rho guanine nucleotide exchange factor (GEF) 12
MGI:1916882
Synonyms
2310014B11Rik, LARG, mKIAA0382
Feature Type
protein coding gene
Genetic Map
Chromosome 9
24.14 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:42963842-43105718 bp, - strand
From NCBI annotation of GRCm38

  141877 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9088  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: PDZ domain-containing Rho guanine nucleotide exchange factor
Gene Tree: Arhgef12

Human
homologs
Human Homolog ARHGEF12, Rho guanine nucleotide exchange factor (GEF) 12
NCBI Gene ID 23365
neXtProt AC  NX_Q9NZN5
Human Synonyms  LARG, PRO2792
Human Chr (Location)  11q23.3; chr11:120336555-120489936 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Gene trapped(38) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased sensitivity to certain vasoconstrictors and resistance to salt-induced hypertension. Mice homozygous for a different knock-out allele exhibit partial prenatal lethality.
 
Interactions
Arhgef12 interacts with 488 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (30)    Tissues (20)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Northern blot 6
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000059495 (Evidence)
Entrez Gene69632 (Evidence)
NIA Mouse Gene IndexU030755
Consensus CDS ProjectCCDS40595.1
International Mouse Knockout Project StatusArhgef12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 69632 NCBI Gene Model | MGI Sequence Detail 141877 C57BL/6J ±  kb
transcript NM_027144 RefSeq | MGI Sequence Detail 10483 Not Specified 
polypeptide Q8R4H2 UniProt | EBI | MGI Sequence Detail 1543 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(9)
Polymorphisms
SNPs within 2kb(643 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001478 PDZ domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR015212 Regulator of G protein signalling-like fold
InterPro IPR016137 Regulator of G protein signalling superfamily
InterPro IPR015721 Rho GTP exchange factor
Protein Ontology PR:000004249 rho guanine nucleotide exchange factor 12
Graphical View of Protein Domain Structure
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:207976 Li Q, et al., The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife. 2014;3:e01201
All references(51)
Other
accession IDs
MGI:2143206

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory