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Pofut2 Gene Detail
Summary
  • Symbol
    Pofut2
  • Name
    protein O-fucosyltransferase 2
  • Synonyms
    2310011G23Rik, FUT13, MGC:6943
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916863
    NCBI Gene: 80294
Location & Maps
more
  • Sequence Map
    Chr10:77259300-77269586 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10287 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    POFUT2, protein O-fucosyltransferase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POFUT2, protein O-fucosyltransferase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C21orf80, FUT13
  • Links
    NCBI Gene ID: 23275
    neXtProt AC: NX_Q9Y2G5

  • Chr Location
    21q22.3; chr21:45263928-45287899 (-)  GRCh38.p2

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    8
  • Targeted
    3
  • Genomic Mutations
    4 involving Pofut2
Homozygous mutation of this gene results in lethality before weaning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 80294 NCBI Gene Model | MGI Sequence Detail 10287 C57BL/6J ±  kb
transcript NM_030262 RefSeq | MGI Sequence Detail 2219 C57BL/6  
polypeptide Q8VHI3 UniProt | EBI | MGI Sequence Detail 429 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    53 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000012959 GDP-fucose protein O-fucosyltransferase 2
  • EC
  • InterPro Domains
    IPR019378 GDP-fucose protein O-fucosyltransferase
Molecular
Reagents
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  • All nucleic 97
    cDNA 93
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
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MGI:1933140, MGI:2143552
References
more
  • Summaries
    All 38
    Developmental Gene Expression 6
    Diseases 2
    Gene Ontology 4
    Phenotypes 23
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:165751 Du J, et al., O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory