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Pofut2 Gene Detail
Summary
  • Symbol
    Pofut2
  • Name
    protein O-fucosyltransferase 2
  • Synonyms
    2310011G23Rik, FUT13, MGC:6943
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916863
    NCBI Gene: 80294
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:77259218-77269575 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916863
protein coding gene Chr10:77259218-77269586 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017395
protein coding gene Chr10:77555339-77565625 (+)
A/J MGP_AJ_G0017372
protein coding gene Chr10:74874551-74884837 (+)
AKR/J MGP_AKRJ_G0017333
protein coding gene Chr10:76884258-76894544 (+)
BALB/cJ MGP_BALBcJ_G0017332
protein coding gene Chr10:75066059-75076345 (+)
C3H/HeJ MGP_C3HHeJ_G0017156
protein coding gene Chr10:76961658-76971944 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017790
protein coding gene Chr10:80285794-80296080 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015480
protein coding gene Chr10:71302464-71312876 (+)
CAST/EiJ MGP_CASTEiJ_G0016726
protein coding gene Chr10:77305472-77315922 (+)
CBA/J MGP_CBAJ_G0017128
protein coding gene Chr10:83416708-83426994 (+)
DBA/2J MGP_DBA2J_G0017233
protein coding gene Chr10:74159981-74170267 (+)
FVB/NJ MGP_FVBNJ_G0017225
protein coding gene Chr10:73329150-73339436 (+)
LP/J MGP_LPJ_G0017306
protein coding gene Chr10:78028512-78038798 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017254
protein coding gene Chr10:85446585-85456871 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017829
protein coding gene Chr10:76954461-76964747 (+)
PWK/PhJ MGP_PWKPhJ_G0016510
protein coding gene Chr10:74023981-74034412 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016293
protein coding gene Chr10:76218662-76228999 (+)
WSB/EiJ MGP_WSBEiJ_G0016789
protein coding gene Chr10:76930654-76941020 (+)



Homology
more
  • Human Ortholog
    POFUT2, protein O-fucosyltransferase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POFUT2, protein O-fucosyltransferase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C21orf80, FUT13
  • Links
    NCBI Gene ID: 23275
    neXtProt AC: NX_Q9Y2G5
    UniProt: Q9Y2G5

  • Chr Location
    21q22.3; chr21:45263928-45287912 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12724
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: POFUT2
  • Gene Tree
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 4 alleles in 5 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality before weaning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020260 Ensembl Gene Model | MGI Sequence Detail 10358 C57BL/6J ±  kb
    transcript ENSMUST00000020493 Ensembl | MGI Sequence Detail 2290 Not Applicable  
    polypeptide ENSMUSP00000020493 Ensembl | MGI Sequence Detail 429 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      cDNA 93
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1933140, MGI:2143552
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 5
      Phenotypes 29
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory