Pofut2
Gene Detail

Symbol Name ID

Pofut2 protein O-fucosyltransferase 2 MGI:1916863

Synonyms

2310011G23Rik, FUT13, MGC:6943

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:77259300-77269586 bp, + strand From NCBI annotation of GRCm38   10287 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Pofut2 ± 2 cM)

Gene Tree: Pofut2

Human ortholog

POFUT2 protein O-fucosyltransferase 2 NCBI Gene ID 23275
Human Synonyms: C21orf80, FUT13
Human Chr21:46683843-46707811 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(8) : Gene trapped(8)
 

Homozygous mutation of this gene results in lethality before weaning.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	carbohydrate metabolic process, fucose metabolic process, ...
Component	endoplasmic reticulum, Golgi apparatus
Function	fucosyltransferase activity, peptide-O-fucosyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (254)    Tissues (145)    Images (27)
Theiler Stages: 9, 11, 13, 15, 17, 20, 22, 23, 26, 28

Assay Type	Results
RNA in situ	192
In situ reporter (knock in)	36
RT-PCR	26

cDNA source data(91)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(97) cDNA(93) Primer pair(4)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000020260 (Evidence)
Entrez Gene	80294 (Evidence)
UniGene	203556
DFCI	TC1572825
DoTS	DT.110624058, DT.533532
NIA Mouse Gene Index	U011684
EC	2.4.1.221
Consensus CDS Project	CCDS23954.1
International Mouse Knockout Project Status	Pofut2

Sequences

Length	Strain/Species
genomic	80294	NCBI Gene Model | MGI Sequence Detail	10287	C57BL/6J
transcript	NM_030262	RefSeq | MGI Sequence Detail	2219	C57BL/6
polypeptide	Q8VHI3	UniProt | EBI | MGI Sequence Detail	429	Not Applicable

All sequences(39) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(46 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019378	GDP-fucose protein O-fucosyltransferase
Protein Ontology	PR:000012959	GDP-fucose protein O-fucosyltransferase 2

Graphical View of Protein Domain Structure

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:165751 Du J, et al., O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
All references(42)

Other accession IDs

MGI:1933140, MGI:2143552