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Tnfsf13 Gene Detail
Summary
  • Symbol
    Tnfsf13
  • Name
    tumor necrosis factor (ligand) superfamily, member 13
  • Synonyms
    2310026N09Rik, APRIL, TALL2, TRDL1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916833
    NCBI Gene: 69583
  • Gene Overview
    MyGene.info: TNFSF13
Location & Maps
more
  • Sequence Map
    Chr11:69682846-69685784 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2939 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.86 cM, cytoband B4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TNFSF13, tumor necrosis factor superfamily member 13
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TNFSF13, tumor necrosis factor superfamily member 13
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APRIL, CD256, TALL2, TALL-2, TNLG7B, TRDL-1, UNQ383/PRO715, ZTNF2
  • Links
    NCBI Gene ID: 8741
    neXtProt AC: NX_O75888

  • Chr Location
    17p13.1; chr17:7558292-7561608 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    2 involving Tnfsf13
  • Incidental Mutations
    APF
Homozygous null mice are viable and fertile. No apparent defects of the immune system have been reported.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006001 VEGA Gene Model | MGI Sequence Detail 2939 C57BL/6J ±  kb
transcript OTTMUST00000013436 VEGA | MGI Sequence Detail 1407 Not Applicable  
polypeptide OTTMUSP00000006221 VEGA | MGI Sequence Detail 240 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    35 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 1
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 6
    Phenotypes 27
  • Earliest
    J:71877 Yu G, et al., APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. Nat Immunol. 2000 Sep;1(3):252-6
  • Latest
    J:224238 Matthes T, et al., Myelopoiesis dysregulation associated to sustained APRIL production in multiple myeloma-infiltrated bone marrow. Leukemia. 2015 Sep;29(9):1901-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory