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Hilpda Gene Detail
Summary
  • Symbol
    Hilpda
  • Name
    hypoxia inducible lipid droplet associated
  • Synonyms
    2310016C08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916823
    NCBI Gene: 69573
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:29272488-29275446 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 12.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916823
protein coding gene Chr6:29272488-29275449 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030517
protein coding gene Chr6:27054002-27056960 (+)
A/J MGP_AJ_G0030490
protein coding gene Chr6:25908919-25911877 (+)
AKR/J MGP_AKRJ_G0030417
protein coding gene Chr6:26765544-26768501 (+)
BALB/cJ MGP_BALBcJ_G0030500
protein coding gene Chr6:26066327-26069285 (+)
C3H/HeJ MGP_C3HHeJ_G0030213
protein coding gene Chr6:26764913-26767871 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030954
protein coding gene Chr6:27833815-27836773 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028165
protein coding gene Chr6:24118760-24121897 (+)
CAST/EiJ MGP_CASTEiJ_G0029615
protein coding gene Chr6:26562383-26565344 (+)
CBA/J MGP_CBAJ_G0030191
protein coding gene Chr6:28864897-28867855 (+)
DBA/2J MGP_DBA2J_G0030335
protein coding gene Chr6:25856641-25859599 (+)
FVB/NJ MGP_FVBNJ_G0030289
protein coding gene Chr6:25606214-25609668 (+)
LP/J MGP_LPJ_G0030422
protein coding gene Chr6:27186353-27189311 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030325
protein coding gene Chr6:31400393-31403351 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030984
protein coding gene Chr6:26637205-26640163 (+)
PWK/PhJ MGP_PWKPhJ_G0029329
protein coding gene Chr6:25388934-25391900 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029165
protein coding gene Chr6:26365446-26370020 (+)
WSB/EiJ MGP_WSBEiJ_G0029691
protein coding gene Chr6:26606314-26609272 (+)



Homology
more
  • Human Ortholog
    HILPDA, hypoxia inducible lipid droplet associated
  • Vertebrate Orthologs
    5
  • Human Ortholog
    HILPDA, hypoxia inducible lipid droplet associated
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C7orf68, HIG2, HIG-2
  • Links
    NCBI Gene ID: 29923
    neXtProt AC: NX_Q9Y5L2
    UniProt: Q9Y5L2

  • Chr Location
    7q32.1; chr7:128455830-128458418 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043421 Ensembl Gene Model | MGI Sequence Detail 2959 C57BL/6J ±  kb
transcript ENSMUST00000115289 Ensembl | MGI Sequence Detail 658 Not Applicable  
polypeptide ENSMUSP00000110944 Ensembl | MGI Sequence Detail 64 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008558 hypoxia-inducible lipid droplet-associated protein
  • InterPro Domains
    IPR026190 Hypoxia-inducible lipid droplet-associated protein
Molecular
Reagents
less
  • All nucleic 33
    cDNA 33

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141637
References
more
  • Summaries
    All 31
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:253318 Maier A, et al., Hypoxia-inducible protein 2 Hig2/Hilpda mediates neutral lipid accumulation in macrophages and contributes to atherosclerosis in apolipoprotein E-deficient mice. FASEB J. 2017 Nov;31(11):4971-4984

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory