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Prss56
Gene Detail
Symbol

Name
ID
Prss56
protease, serine 56
MGI:1916703
Synonyms
1700027L20Rik, Prss56
Feature Type
protein coding gene
Genetic Map
Chromosome 1
44.07 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:87183313-87188405 bp, + strand
From VEGA annotation of GRCm38

  5093 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:79885  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Prss56

Human
homologs
Human Homolog PRSS56, protease, serine, 56
NCBI Gene ID 646960
neXtProt AC  NX_P0CW18
Human Synonyms  MCOP6
Human Chr (Location)  2q37.1; chr2:232520463-232525716 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PRSS56
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Chemically induced (ENU)(1)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for an ENU induced mutation show increased intraocular pressure, variable decreases in eye axial length, and narrow iridocorneal angles. Homozygous mice model angle-closure glaucoma.
 
Human Diseases Modeled Using Mouse Prss56 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Prss56 interacts with 3 markers (Mir9-1, Mir9-2, Mir9-3)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process camera-type eye development, proteolysis
Component endoplasmic reticulum, membrane
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 19
RT-PCR 8
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(3) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000033560 (Evidence)
Ensembl Gene ModelENSMUSG00000036480 (Evidence)
Entrez Gene69453 (Evidence)
UniGene84618
DFCITC1652196
DoTSDT.40179093
NIA Mouse Gene IndexU000551
EC3.4.21.-
Consensus CDS ProjectCCDS59538.1
International Mouse Knockout Project StatusPrss56
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033560 VEGA Gene Model | MGI Sequence Detail 5093 C57BL/6J ±  kb
transcript OTTMUST00000084503 VEGA | MGI Sequence Detail 2180 Not Applicable 
polypeptide OTTMUSP00000063620 VEGA | MGI Sequence Detail 604 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(8) UniProt(1)
Polymorphisms
SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:188765 Nair KS, et al., Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice. Nat Genet. 2011 Jun;43(6):579-84
All references(24)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory