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Prss56 Gene Detail
Summary
  • Symbol
    Prss56
  • Name
    protease, serine 56
  • Synonyms
    1700027L20Rik, Prss56
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916703
    NCBI Gene: 69453
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87183313-87188405 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 44.07 cM, cytoband C5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916703
protein coding gene Chr1:87183102-87188405 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016258
protein coding gene Chr1:88519271-88524363 (+)
A/J MGP_AJ_G0016239
protein coding gene Chr1:85211576-85216668 (+)
AKR/J MGP_AKRJ_G0016200
protein coding gene Chr1:87727825-87732917 (+)
BALB/cJ MGP_BALBcJ_G0016196
protein coding gene Chr1:85331041-85336133 (+)
C3H/HeJ MGP_C3HHeJ_G0016024
protein coding gene Chr1:87987523-87992615 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016652
protein coding gene Chr1:91859241-91864333 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014374
protein coding gene Chr1:79661631-79666733 (+)
CAST/EiJ MGP_CASTEiJ_G0015609
protein coding gene Chr1:87190972-87196066 (+)
CBA/J MGP_CBAJ_G0016000
protein coding gene Chr1:94728284-94733376 (+)
DBA/2J MGP_DBA2J_G0016103
protein coding gene Chr1:84514994-84520086 (+)
FVB/NJ MGP_FVBNJ_G0016102
protein coding gene Chr1:83575435-83580558 (+)
LP/J MGP_LPJ_G0016174
protein coding gene Chr1:89584039-89589131 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016128
protein coding gene Chr1:98018322-98023414 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016695
protein coding gene Chr1:87827419-87832509 (+)
PWK/PhJ MGP_PWKPhJ_G0015396
protein coding gene Chr1:83811634-83816727 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015176
protein coding gene Chr1:86752290-86757392 (+)
WSB/EiJ MGP_WSBEiJ_G0015673
protein coding gene Chr1:87495532-87500624 (+)



Homology
more
  • Human Ortholog
    PRSS56, serine protease 56
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRSS56, serine protease 56
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MCOP6
  • Links
    NCBI Gene ID: 646960
    neXtProt AC: NX_P0CW18
    UniProt: P0CW18

  • Chr Location
    2q37.1; chr2:232520463-232525716 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Prss56 mouse models; 1 with human PRSS56 associations

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU induced mutation show increased intraocular pressure, variable decreases in eye axial length, and narrow iridocorneal angles. Homozygous mice model angle-closure glaucoma.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036480 Ensembl Gene Model | MGI Sequence Detail 5093 C57BL/6J ±  kb
    transcript ENSMUST00000044533 Ensembl | MGI Sequence Detail 2180 Not Applicable  
    polypeptide ENSMUSP00000138773 Ensembl | MGI Sequence Detail 604 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • EC
    • InterPro Domains
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR009003 Peptidase S1, PA clan
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
      IPR033116 Serine proteases, trypsin family, serine active site
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 4
      Primer pair 2
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:269961 Radomska KJ, et al., Cellular Origin, Tumor Progression, and Pathogenic Mechanisms of Cutaneous Neurofibromas Revealed by Mice with Nf1 Knockout in Boundary Cap Cells. Cancer Discov. 2019 Jan;9(1):130-147

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/01/2019
    MGI 6.14
    The Jackson Laboratory