Prss56
Gene Detail

Symbol Name ID

Prss56 protease, serine 56 MGI:1916703

BioType Conflict

Synonyms

1700027L20Rik, Prss56

Feature Type

lincRNA gene

Genetic Map

Chromosome 1

44.07 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:87186665-87188403 bp, + strand From VEGA annotation of GRCm38   1739 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:79885  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Prss56

Human homologs

Human Homolog		PRSS56, protease, serine, 56
NCBI Gene ID		646960
neXtProt AC		NX_P0CW18
Human Synonyms		MCOP6
Human Chr (Location)		2q37.1; chr2:233385173-233390426 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PRSS56

Alleles and phenotypes

All alleles(1) : Chemically induced(1)
 

Mice homozygous for an ENU induced mutation show increased intraocular pressure, variable decreases in eye axial length, and narrow iridocorneal angles. Homozygous mice model angle-closure glaucoma.

 
Human Diseases Modeled Using Mouse Prss56 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	camera-type eye development, proteolysis
Component	cellular_component
Function	hydrolase activity, peptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (17)   
Theiler Stages: 17, 20, 22, 24, 25, 28

Assay Type	Results
RNA in situ	19
RT-PCR	8

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(3) Primer pair(2) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000033560 (Evidence)
Ensembl Gene Model	ENSMUSG00000036480 (Evidence)
Entrez Gene	69453 (Evidence)
UniGene	84618
DFCI	TC1652196
DoTS	DT.40179093
NIA Mouse Gene Index	U000551
International Mouse Knockout Project Status	Prss56

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033560	VEGA Gene Model | MGI Sequence Detail	1739	C57BL/6J
transcript	OTTMUST00000084503	VEGA | MGI Sequence Detail	884	Not Applicable
polypeptide	NP_081360	RefSeq | MGI Sequence Detail	604	C57BL/6

All sequences(16) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:188765 Nair KS, et al., Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice. Nat Genet. 2011 Jun;43(6):579-84
All references(23)