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Prss56
Gene Detail
Symbol

Name
ID
Prss56
protease, serine 56
MGI:1916703
Synonyms
1700027L20Rik, Prss56
Feature Type
protein coding gene
Genetic Map
Chromosome 1
44.07 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:87183313-87188405 bp, + strand
From VEGA annotation of GRCm38

  5093 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:79885  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: PRSS56
Gene Tree: Prss56

Human
homologs
PRSS56, protease, serine, 56
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 646960
neXtProt AC: NX_P0CW18

Human Synonyms: MCOP6

Human Chr (Location): 2q37.1; chr2:232520463-232525716 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PRSS56

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Chemically induced (ENU)(1) Endonuclease-mediated(1)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for an ENU induced mutation show increased intraocular pressure, variable decreases in eye axial length, and narrow iridocorneal angles. Homozygous mice model angle-closure glaucoma.
 
Human Diseases Modeled in Mice Using Prss56 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Prss56 interacts with 3 markers (Mir9-1, Mir9-2, Mir9-3)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process camera-type eye development, proteolysis
Component endoplasmic reticulum, membrane
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (27)    Tissues (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 19
RT-PCR 8
cDNA source data(3)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(3) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000033560 (Evidence)
Ensembl Gene Model ENSMUSG00000036480 (Evidence)
Entrez Gene 69453 (Evidence)
UniGene 84618
DFCI TC1652196
DoTS DT.40179093
NIA Mouse Gene Index U000551
EC 3.4.21.-
Consensus CDS Project CCDS59538.1
International Mouse Phenotyping Consortium Status Prss56
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033560 VEGA Gene Model | MGI Sequence Detail 5093 C57BL/6J ±  kb
transcript OTTMUST00000084503 VEGA | MGI Sequence Detail 2180 Not Applicable 
polypeptide OTTMUSP00000063620 VEGA | MGI Sequence Detail 604 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(8) UniProt(1)
Polymorphisms
SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR009003 Peptidase S1, PA clan
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001254 Serine proteases, trypsin domain
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:188765 Nair KS, et al., Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice. Nat Genet. 2011 Jun;43(6):579-84
All references(23)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory