Prss21
Gene Detail

Symbol Name ID

Prss21 protease, serine, 21 MGI:1916698

Synonyms

1700023E12Rik, mT4, TESP5, testisin

Feature Type

protein coding gene

Genetic Map

Chromosome 17

12.11 cM, cytoband A3.3-B
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:23868056-23873114 bp, + strand From VEGA annotation of GRCm38   5059 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:123885  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 16 zebrafish

Protein SuperFamily: trypsin
Gene Tree: Prss21

Human homologs

Human Homolog		PRSS21, protease, serine, 21 (testisin)
NCBI Gene ID		10942
neXtProt AC		NX_Q9Y6M0
Human Synonyms		ESP1, ESP-1, TEST1, TESTISIN
Human Chr (Location)		16p13.3; chr16:2867164-2871723 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for one knock-out allele impaires fertilization of epididymal sperm only in an in vitro experiment. Mice homozygous for another knock-out allele exhibit defective sperm maturation during passage through the epididymis and decreased sperm fertilization capability.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	metabolic process, proteolysis, ...
Component	anchored to membrane, cytoplasm, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (20)    Tissues (20)    Images (1)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
RT-PCR	20

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000023199 (Evidence)
Ensembl Gene Model	ENSMUSG00000024116 (Evidence)
Entrez Gene	57256 (Evidence)
UniGene	386785
DFCI	TC1588053
DoTS	DT.40168751
NIA Mouse Gene Index	U017626
EC	3.4.21.-
Consensus CDS Project	CCDS28468.1
International Mouse Knockout Project Status	Prss21

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023199	VEGA Gene Model | MGI Sequence Detail	5059	C57BL/6J
transcript	OTTMUST00000056127	VEGA | MGI Sequence Detail	1094	Not Applicable
polypeptide	OTTMUSP00000026936	VEGA | MGI Sequence Detail	324	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(106 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000013321	testisin

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)