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Prss21 Gene Detail
Summary
  • Symbol
    Prss21
  • Name
    protease, serine 21
  • Synonyms
    1700023E12Rik, mT4, TESP5, testisin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916698
    NCBI Gene: 57256
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:23868056-23873114 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.11 cM, cytoband A3.3-B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    123 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916698
protein coding gene Chr17:23867868-23873114 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023277
protein coding gene Chr17:22802621-22807649 (+)
A/J MGP_AJ_G0023237
protein coding gene Chr17:22138514-22143542 (+)
AKR/J MGP_AKRJ_G0023207
protein coding gene Chr17:22218711-22223740 (+)
BALB/cJ MGP_BALBcJ_G0023242
protein coding gene Chr17:22348765-22353793 (+)
C3H/HeJ MGP_C3HHeJ_G0023002
protein coding gene Chr17:22588990-22594018 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023685
protein coding gene Chr17:23782707-23787765 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021166
protein coding gene Chr17:19694896-19700076 (+)
CAST/EiJ MGP_CASTEiJ_G0022508
protein coding gene Chr17:22413342-22418405 (+)
CBA/J MGP_CBAJ_G0022978
protein coding gene Chr17:24607082-24612110 (+)
DBA/2J MGP_DBA2J_G0023110
protein coding gene Chr17:21770843-21775871 (+)
FVB/NJ MGP_FVBNJ_G0023077
protein coding gene Chr17:21488073-21493101 (+)
LP/J MGP_LPJ_G0023184
protein coding gene Chr17:23063075-23068103 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023096
protein coding gene Chr17:24348718-24353744 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023724
protein coding gene Chr17:22515698-22520726 (+)
PWK/PhJ MGP_PWKPhJ_G0022256
protein coding gene Chr17:20551731-20556787 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022076
protein coding gene Chr17:20533242-20538279 (+)
WSB/EiJ MGP_WSBEiJ_G0022571
protein coding gene Chr17:22566628-22571662 (+)



Homology
more
  • Human Ortholog
    PRSS21, serine protease 21
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PRSS21, serine protease 21
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ESP1, ESP-1, TEST1, TESTISIN
  • Links
    NCBI Gene ID: 10942
    neXtProt AC: NX_Q9Y6M0
    UniProt: Q9Y6M0

  • Chr Location
    16p13.3; chr16:2817163-2821722 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele impaires fertilization of epididymal sperm only in an in vitro experiment. Mice homozygous for another knock-out allele exhibit defective sperm maturation during passage through the epididymis and decreased spermfertilization capability.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024116 Ensembl Gene Model | MGI Sequence Detail 5059 C57BL/6J ±  kb
transcript ENSMUST00000024928 Ensembl | MGI Sequence Detail 1094 Not Applicable  
polypeptide ENSMUSP00000024928 Ensembl | MGI Sequence Detail 324 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 8
    Primer pair 2
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:203850 Asano A, et al., Phospholipase B is activated in response to sterol removal and stimulates acrosome exocytosis in murine sperm. J Biol Chem. 2013 Sep 27;288(39):28104-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory