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Prss21
Gene Detail
 Symbol
Name
ID
Prss21
protease, serine 21
MGI:1916698
Synonyms 1700023E12Rik, mT4, TESP5, testisin
Feature Type protein coding gene
Genetic Map
Chromosome 17
12.11 cM, cytoband A3.3-B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:23868056-23873114 bp, + strand
From VEGA annotation of GRCm38

  5059 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137342  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: trypsin
Gene Tree: Prss21

Human
homologs
Human Homolog PRSS21, protease, serine, 21 (testisin)
NCBI Gene ID 10942
neXtProt AC  NX_Q9Y6M0
Human Synonyms  ESP1, ESP-1, TEST1, TESTISIN
Human Chr (Location)  16p13.3; chr16:2817163-2821722 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for one knock-out allele impaires fertilization of epididymal sperm only in an in vitro experiment. Mice homozygous for another knock-out allele exhibit defective sperm maturation during passage through the epididymis and decreased sperm fertilization capability.
 
Interactions
Prss21 interacts with 10 markers (Mir191, Mir329, Mir362, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process proteolysis, spermatogenesis
Component anchored component of membrane, membrane, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (20)    Tissues (20)    Images (1)
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
RT-PCR 20
cDNA source data(6)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023199 (Evidence)
Ensembl Gene ModelENSMUSG00000024116 (Evidence)
Entrez Gene57256 (Evidence)
UniGene386785
DFCITC1588053
DoTSDT.40168751
NIA Mouse Gene IndexU017626
EC3.4.21.-
Consensus CDS ProjectCCDS28468.1
International Mouse Knockout Project StatusPrss21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023199 VEGA Gene Model | MGI Sequence Detail 5059 C57BL/6J ±  kb
transcript OTTMUST00000056127 VEGA | MGI Sequence Detail 1094 Not Applicable 
polypeptide OTTMUSP00000026936 VEGA | MGI Sequence Detail 324 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(131 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000013321 testisin
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203850 Asano A, et al., Phospholipase B is activated in response to sterol removal and stimulates acrosome exocytosis in murine sperm. J Biol Chem. 2013 Sep 27;288(39):28104-15
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory