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Prss21
Gene Detail
Symbol

Name
ID
Prss21
protease, serine 21
MGI:1916698
Synonyms
1700023E12Rik, mT4, TESP5, testisin
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.11 cM, cytoband A3.3-B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:23868056-23873114 bp, + strand
From VEGA annotation of GRCm38

  5059 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137342  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: PRSS21
Protein SuperFamily: trypsin
Gene Tree: Prss21

Human
homologs
PRSS21, protease, serine, 21 (testisin)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10942
neXtProt AC: NX_Q9Y6M0

Human Synonyms: ESP1, ESP-1, TEST1, TESTISIN

Human Chr (Location): 16p13.3; chr16:2817163-2821722 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for one knock-out allele impaires fertilization of epididymal sperm only in an in vitro experiment. Mice homozygous for another knock-out allele exhibit defective sperm maturation during passage through the epididymis and decreased sperm fertilization capability.
 
Interactions
Prss21 interacts with 10 markers (Mir191, Mir329, Mir362, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process proteolysis, spermatogenesis
Component anchored component of membrane, membrane, ...
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (20)    Tissues (20)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 20
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023199 (Evidence)
Ensembl Gene Model ENSMUSG00000024116 (Evidence)
Entrez Gene 57256 (Evidence)
UniGene 386785
DFCI TC1588053
DoTS DT.40168751
NIA Mouse Gene Index U017626
EC 3.4.21.-
Consensus CDS Project CCDS28468.1
International Mouse Phenotyping Consortium Status Prss21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023199 VEGA Gene Model | MGI Sequence Detail 5059 C57BL/6J ±  kb
transcript OTTMUST00000056127 VEGA | MGI Sequence Detail 1094 Not Applicable 
polypeptide OTTMUSP00000026936 VEGA | MGI Sequence Detail 324 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(131 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR009003 Peptidase S1, PA clan
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001254 Serine proteases, trypsin domain
Protein Ontology PR:000013321 testisin
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:203850 Asano A, et al., Phospholipase B is activated in response to sterol removal and stimulates acrosome exocytosis in murine sperm. J Biol Chem. 2013 Sep 27;288(39):28104-15
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory