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Dnaic1
Gene Detail
 Symbol
Name
ID
Dnaic1
dynein, axonemal, intermediate chain 1
MGI:1916172
Synonyms 1110066F04Rik, b2b1526Clo
Feature Type protein coding gene
Genetic Map
Chromosome 4
21.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:41569775-41638158 bp, + strand
From VEGA annotation of GRCm38

  68384 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8122  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dnaic1

Human
homologs
Human Homolog DNAI1, dynein, axonemal, intermediate chain 1
NCBI Gene ID 27019
neXtProt AC  NX_Q9UI46
Human Synonyms  CILD1, DIC1, ICS1, PCD
Human Chr (Location)  9p13.3; chr9:34458752-34520989 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DNAI1
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(2) Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant mice exhibit situs inversus, heterotaxia and ciliary dyskinesia including cardiovascular defects and decreased ciliary activity in the trachea, reduced to absent mucociliary clearance, and chronic rhinosinusitis. Hydrocephaly is also seen.
 
Human Diseases Modeled Using Mouse Dnaic1 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(31)
Interactions
Dnaic1 interacts with 51 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process epithelial cilium movement
Component cell projection, cilium, ...
Function motor activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006654 (Evidence)
Ensembl Gene ModelENSMUSG00000061322 (Evidence)
Entrez Gene68922 (Evidence)
UniGene79127
DFCITC1584344, TC1643898
DoTSDT.101168890, DT.55274746, DT.91576000
NIA Mouse Gene IndexU004216
Consensus CDS ProjectCCDS18066.1
International Mouse Knockout Project StatusDnaic1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006654 VEGA Gene Model | MGI Sequence Detail 68384 C57BL/6J ±  kb
transcript OTTMUST00000015206 VEGA | MGI Sequence Detail 2510 Not Applicable 
polypeptide OTTMUSP00000007027 VEGA | MGI Sequence Detail 701 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(387 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001680 WD40 repeat
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000006568 dynein intermediate chain 1, axonemal
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:186572 Francis RJ, et al., Congenital heart disease and the specification of left-right asymmetry. Am J Physiol Heart Circ Physiol. 2012 May 15;302(10):H2102-11
All references(35)
Disease annotation references (2)
Other
accession IDs
MGI:2140635, MGI:5317586

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory