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Dnaic1 Gene Detail
Summary
  • Symbol
    Dnaic1
  • Name
    dynein, axonemal, intermediate chain 1
  • Synonyms
    1110066F04Rik, b2b1526Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916172
    NCBI Gene: 68922
  • Gene Overview
    MyGene.info: DNAI1
Location & Maps
more
  • Sequence Map
    Chr4:41569775-41638158 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      68384 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 21.75 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DNAI1, dynein axonemal intermediate chain 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DNAI1, dynein axonemal intermediate chain 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CILD1, DIC1, ICS1, PCD
  • Links
    NCBI Gene ID: 27019
    neXtProt AC: NX_Q9UI46

  • Chr Location
    9p13.3; chr9:34458752-34520989 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Dnaic1 mouse models; 1 with human DNAI1 associations

Human Disease Mouse Models
       Ciliary Dyskinesia, Primary, 1; CILD1   OMIM: 244400 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 4 alleles in 4 genetic backgrounds
    31 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically and radiation induced
    1
  • Chemically induced (ENU)
    2
  • Gene trapped
    2
  • Targeted
    4
  • Genomic Mutations
    1 involving Dnaic1
  • Incidental Mutations
Mutant mice exhibit situs inversus, heterotaxia and ciliary dyskinesia including cardiovascular defects and decreased ciliary activity in the trachea, reduced to absent mucociliary clearance, and chronic rhinosinusitis. Hydrocephaly is also seen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006654 VEGA Gene Model | MGI Sequence Detail 68384 C57BL/6J ±  kb
transcript OTTMUST00000015206 VEGA | MGI Sequence Detail 2510 Not Applicable  
polypeptide OTTMUSP00000007027 VEGA | MGI Sequence Detail 701 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    377 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140635, MGI:5317586
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Diseases 2
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:231237 Young SA, et al., CRISPR/Cas9-Mediated Rapid Generation of Multiple Mouse Lines Identified Ccdc63 as Essential for Spermiogenesis. Int J Mol Sci. 2015;16(10):24732-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory