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Dnaic1 Gene Detail
Summary
  • Symbol
    Dnaic1
  • Name
    dynein, axonemal, intermediate chain 1
  • Synonyms
    1110066F04Rik, b2b1526Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916172
    NCBI Gene: 68922
  • Gene Overview
    MyGene.info: DNAI1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:41569775-41638158 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 21.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    377 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916172
protein coding gene Chr4:41569698-41638158 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028165
protein coding gene Chr4:39524318-39594184 (+)
A/J MGP_AJ_G0028123
protein coding gene Chr4:38016953-38084967 (+)
AKR/J MGP_AKRJ_G0028086
protein coding gene Chr4:39009553-39078228 (+)
BALB/cJ MGP_BALBcJ_G0028135
protein coding gene Chr4:38350780-38418934 (+)
C3H/HeJ MGP_C3HHeJ_G0027863
protein coding gene Chr4:39550201-39619590 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028576
protein coding gene Chr4:40987350-41060361 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025917
protein coding gene Chr4:35672393-35739147 (+)
CAST/EiJ MGP_CASTEiJ_G0027319
protein coding gene Chr4:39225767-39296921 (+)
CBA/J MGP_CBAJ_G0027835
protein coding gene Chr4:42382659-42457238 (+)
DBA/2J MGP_DBA2J_G0027979
protein coding gene Chr4:37953796-38022094 (+)
FVB/NJ MGP_FVBNJ_G0027946
protein coding gene Chr4:37268153-37336597 (+)
LP/J MGP_LPJ_G0028087
protein coding gene Chr4:39597664-39665122 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027979
protein coding gene Chr4:45678854-45750491 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028635
protein coding gene Chr4:39114872-39185885 (+)
PWK/PhJ MGP_PWKPhJ_G0027038
protein coding gene Chr4:37967754-38037079 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026865
protein coding gene Chr4:38849174-38918351 (+)
WSB/EiJ MGP_WSBEiJ_G0027395
protein coding gene Chr4:39103279-39171916 (+)



Homology
more
  • Human Ortholog
    DNAI1, dynein axonemal intermediate chain 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DNAI1, dynein axonemal intermediate chain 1
    Orthology source: HomoloGene
  • Synonyms
    CILD1, DIC1, ICS1, PCD
  • Links
    NCBI Gene ID: 27019
    neXtProt AC: NX_Q9UI46
    UniProt: Q9UI46

  • Chr Location
    9p13.3; chr9:34458752-34520989 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Dnaic1 mouse models; 1 with human DNAI1 associations

Human Disease Mouse Models
      
IDs
View 3 models
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 4 alleles in 4 genetic backgrounds
    31 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutant mice exhibit situs inversus, heterotaxia and ciliary dyskinesia including cardiovascular defects and decreased ciliary activity in the trachea, reduced to absent mucociliary clearance, and chronic rhinosinusitis. Hydrocephaly is also seen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061322 Ensembl Gene Model | MGI Sequence Detail 68384 C57BL/6J ±  kb
    transcript ENSMUST00000102963 Ensembl | MGI Sequence Detail 2510 Not Applicable  
    polypeptide ENSMUSP00000100028 Ensembl | MGI Sequence Detail 701 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR001680 WD40 repeat
      IPR017986 WD40-repeat-containing domain
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140635, MGI:5317586
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:240425 Gao FJ, et al., Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein. Mol Biol Cell. 2017 Mar 01;28(5):587-599

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory