Dusp22 MGI Mouse Gene Detail - MGI:1915926 - dual specificity phosphatase 22

Symbol

Dusp22
Name

dual specificity phosphatase 22
Synonyms

1110028K04Rik, JKAP, JSP1

Feature Type

protein coding gene
IDs

MGI:1915926
NCBI Gene: 105352
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:30844042-30895215 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 13.26 cM
Mapping Data

2 experiments

SNPs within 2kb

1349 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915926	protein coding gene	Chr13:30843982-30895215 (+)
129S1/SvImJ	ENSMUSG00200027724	protein coding gene	Chr13:27998979-28050337 (+)
A/J	ENSMUSG00195037073	protein coding gene	Chr13:27153899-27205170 (+)
AKR/J	ENSMUSG00220012799	protein coding gene	Chr13:27008992-27060284 (+)
BALB/cJ	ENSMUSG00180022068	protein coding gene	Chr13:27454024-27505300 (+)
C3H/HeJ	ENSMUSG00175030578	protein coding gene	Chr13:27476442-27527710 (+)
C57BL/6NJ	ENSMUSG00215007775	protein coding gene	Chr13:27619378-27670616 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018392	protein coding gene	Chr13:26201697-26252662 (+)
CAST/EiJ	ENSTCUG00005010037	protein coding gene	Chr13:27612049-27663051 (+)
CBA/J	ENSMUSG00210026194	protein coding gene	Chr13:27420106-27471379 (+)
DBA/2J	ENSMUSG00185019131	protein coding gene	Chr13:28239155-28290438 (+)
FVB/NJ	ENSMUSG00205019020	protein coding gene	Chr13:27243851-27295086 (+)
JF1/MsJ	ENSUMUG00000015211	protein coding gene	Chr13:27864449-27916238 (+)
LP/J	ENSMUSG00230018891	protein coding gene	Chr13:37563805-37615079 (+)
NOD/ShiLtJ	ENSMUSG00190028945	protein coding gene	Chr13:27613943-27665213 (+)
NZO/HlLtJ	ENSMUSG00225033869	protein coding gene	Chr13:31346657-31397920 (+)
PWK/PhJ	ENSLUMG00010027821	protein coding gene	Chr13:26679518-26731265 (+)
SPRET/EiJ	ENSMSPG00010023181	protein coding gene	Chr13:26739609-26790758 (+)
WSB/EiJ	ENSIUOG00005015446	protein coding gene	Chr13:26815752-26866761 (+)

Human Ortholog

DUSP22, dual specificity phosphatase 22

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DUSP22, dual specificity phosphatase 22
Synonyms

JKAP, JSP-1, JSP1, LMW-DSP2, LMWDSP2, MKP-x, MKPX, VHX
Links

HGNC:16077

NCBI Gene ID: 56940

UniProt: Q9NRW4
Chr Location

6p25.3; chr6:291630-351355 (+) GRCh38

MGI Vertebrate Homology

Dusp22 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DUSP22
Gene Tree

Dusp22

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Phenotype Summary

27 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

7
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Dusp22
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele develop inflammation and autoimmunity as they age, are more susceptible to experimental autoimmune encephalomyelitis, exhibit enhanced T-cell mediated and reduced B-cell mediated immune responses.

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All GO Annotations

57
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

704
Tissues

104
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dusp22

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All Sequences

52
RefSeq

4
UniProt

3
CCDS

CCDS26417.1, CCDS26418.1

Ensembl

ENSMUSG00000069255 (Evidence)
NCBI Gene

105352

			Length	Strain/Species	Flank
genomic	105352	NCBI Gene Model \| MGI Sequence Detail	51174	C57BL/6J	± kb
transcript	NM_001037955	RefSeq \| MGI Sequence Detail	3058	C57BL/6
polypeptide	Q99N11	UniProt \| EBI \| MGI Sequence Detail	184	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006748 dual specificity protein phosphatase 22

(term hierarchy)
EC

3.1.3.16, 3.1.3.48
InterPro Domains

IPR000340 Dual specificity phosphatase, catalytic domain

IPR020422 Dual specificity protein phosphatase domain

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 14

Genomic 2

cDNA 11

Primer pair 1

Microarray probesets 6

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MGI:2145423

Summaries

All 54

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 20
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:351183 Shih YC, et al., The phosphatase DUSP22 inhibits UBR2-mediated K63-ubiquitination and activation of Lck downstream of TCR signalling. Nat Commun. 2024 Jan 15;15(1):532

TSS for Dusp22:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119090	Chr13:30843871-30843924 (+)	-144 bp
Tssr4029	Chr13:30843937-30843960 (+)	-93 bp
Tssr119091	Chr13:30844027-30844099 (+)	21 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24