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Dusp22 Gene Detail
Summary
  • Symbol
    Dusp22
  • Name
    dual specificity phosphatase 22
  • Synonyms
    1110028K04Rik, JKAP, JSP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915926
    NCBI Gene: 105352
  • Gene Overview
    MyGene.info: DUSP22
Location & Maps
more
  • Sequence Map
    Chr13:30659999-30711231 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51233 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 13.26 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DUSP22, dual specificity phosphatase 22
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DUSP22, dual specificity phosphatase 22
    Orthology source: HGNC, HomoloGene
  • Synonyms
    JKAP, JSP1, JSP-1, LMWDSP2, LMW-DSP2, MKP-x, MKPX, VHX
  • Links
    NCBI Gene ID: 56940
    neXtProt AC: NX_Q9NRW4

  • Chr Location
    6p25.3; chr6:292057-351355 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Dusp22
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000672 VEGA Gene Model | MGI Sequence Detail 51233 C57BL/6J ±  kb
transcript OTTMUST00000001299 VEGA | MGI Sequence Detail 676 Not Applicable  
polypeptide OTTMUSP00000000617 VEGA | MGI Sequence Detail 205 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    230 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006748 dual specificity protein phosphatase 22
  • EC
  • InterPro Domains
    IPR020417 Atypical dual specificity phosphatase
    IPR024950 Dual specificity phosphatase
    IPR000340 Dual specificity phosphatase, catalytic domain
    IPR020422 Dual specificity protein phosphatase domain
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
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  • All nucleic 13
    Genomic 1
    cDNA 11
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:2145423
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:213253 Li JP, et al., The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck. Nat Commun. 2014;5:3618

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory