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Dusp22 Gene Detail
Summary
  • Symbol
    Dusp22
  • Name
    dual specificity phosphatase 22
  • Synonyms
    1110028K04Rik, JKAP, JSP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915926
    NCBI Gene: 105352
  • Gene Overview
    MyGene.info: DUSP22
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:30660059-30711232 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 13.26 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    230 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915926
protein coding gene Chr13:30659999-30711232 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020415
protein coding gene Chr13:28526995-28579706 (+)
A/J MGP_AJ_G0020370
protein coding gene Chr13:27802793-27853904 (+)
AKR/J MGP_AKRJ_G0020347
protein coding gene Chr13:28405537-28456664 (+)
BALB/cJ MGP_BALBcJ_G0020365
protein coding gene Chr13:27884100-27937918 (+)
C3H/HeJ MGP_C3HHeJ_G0020168
protein coding gene Chr13:28414495-28471112 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020801
protein coding gene Chr13:29524436-29576682 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018392
protein coding gene Chr13:26201697-26252662 (+)
CAST/EiJ MGP_CASTEiJ_G0019685
protein coding gene Chr13:28073486-28124339 (+)
CBA/J MGP_CBAJ_G0020124
protein coding gene Chr13:30773564-30826699 (+)
DBA/2J MGP_DBA2J_G0020246
protein coding gene Chr13:27337200-27388196 (+)
FVB/NJ MGP_FVBNJ_G0020231
protein coding gene Chr13:26940166-26991278 (+)
LP/J MGP_LPJ_G0020323
protein coding gene Chr13:28785397-28838138 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020257
protein coding gene Chr13:30930308-30983233 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020842
protein coding gene Chr13:28044939-28097313 (+)
PWK/PhJ MGP_PWKPhJ_G0019440
protein coding gene Chr13:27488234-27540909 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019261
protein coding gene Chr13:26953635-27005528 (+)
WSB/EiJ MGP_WSBEiJ_G0019747
protein coding gene Chr13:28353351-28405155 (+)



Homology
more
  • Human Ortholog
    DUSP22, dual specificity phosphatase 22
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DUSP22, dual specificity phosphatase 22
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JKAP, JSP1, JSP-1, LMWDSP2, LMW-DSP2, MKP-x, MKPX, VHX
  • Links
    NCBI Gene ID: 56940
    neXtProt AC: NX_Q9NRW4
    UniProt: Q9NRW4

  • Chr Location
    6p25.3; chr6:292057-351355 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 86039
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DUSP22
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 105352 NCBI Gene Model | MGI Sequence Detail 51174 C57BL/6J ±  kb
transcript NM_001037955 RefSeq | MGI Sequence Detail 3058 C57BL/6  
polypeptide Q99N11 UniProt | EBI | MGI Sequence Detail 184 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 2
    cDNA 11
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2145423
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 12
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:213253 Li JP, et al., The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck. Nat Commun. 2014;5:3618

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory