Tab2
Gene Detail

Symbol Name ID

Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 MGI:1915902

Synonyms

1110030N06Rik, A530078N03Rik, Map3k7ip2, mKIAA0733, Tak1 binding protein 2

Feature Type

protein coding gene

Genetic Map

Chromosome 10

2.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr10:7905653-7956230 bp, - strand From VEGA annotation of GRCm38   50578 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9019  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: mitogen-activated protein kinase kinase kinase 7-interacting protein
Gene Tree: Tab2

Human homologs

Human Homolog		TAB2, TGF-beta activated kinase 1/MAP3K7 binding protein 2
NCBI Gene ID		23118
neXtProt AC		NX_Q9NYJ8
Human Synonyms		CHTD2, MAP3K7IP2
Human Chr (Location)		6q25.1; chr6:149639436-149732747 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TAB2

Alleles and phenotypes

All alleles(13) : Targeted(6) Gene trapped(7)
 

Embryos homozygous for a knock-out allele are viable up to E9.5. Embryos homozygous for a different knock-out allele are normal and viable up to E11.5 but become pale and anemic, exhibit liver hemorrhage and increased apoptosis of hepatoblasts, and die by E12.5.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	heart development, positive regulation of protein kinase activity
Component	cytoplasm, nucleus
Function	K63-linked polyubiquitin binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (106)    Tissues (106)    Images (18)
Theiler Stages: 17, 19, 20, 22, 24

Assay Type	Results
RNA in situ	95
RT-PCR	11

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000034128 (Evidence)
Ensembl Gene Model	ENSMUSG00000015755 (Evidence)
Entrez Gene	68652 (Evidence)
DFCI	TC1574750, TC1600876, TC1626063, TC1700740
DoTS	DT.110601053, DT.535223, DT.91358810
NIA Mouse Gene Index	U031511
PDB	3A9J
Consensus CDS Project	CCDS23691.1
International Mouse Knockout Project Status	Tab2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034128	VEGA Gene Model | MGI Sequence Detail	50578	C57BL/6J
transcript	OTTMUST00000086380	VEGA | MGI Sequence Detail	4380	Not Applicable
polypeptide	OTTMUSP00000046773	VEGA | MGI Sequence Detail	693	Not Applicable

All sequences(51) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(47 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003892	Ubiquitin system component Cue
InterPro	IPR001876	Zinc finger, RanBP2-type
Protein Ontology	PR:000001772	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
Protein Ontology	PR:000027104	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (mouse)

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:194994 Takaesu G, et al., TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms. PLoS One. 2012;7(11):e51073
All references(51)

Other accession IDs

MGI:2442803