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Tab2
Gene Detail
Symbol

Name
ID
Tab2
TGF-beta activated kinase 1/MAP3K7 binding protein 2
MGI:1915902
Synonyms
1110030N06Rik, A530078N03Rik, Map3k7ip2, mKIAA0733, Tak1 binding protein 2
Feature Type
protein coding gene
Genetic Map
Chromosome 10
2.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:7905653-7956230 bp, - strand
From VEGA annotation of GRCm38

  50578 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(7) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a knock-out allele are viable up to E9.5. Embryos homozygous for a different knock-out allele are normal and viable up to E11.5 but become pale and anemic, exhibit liver hemorrhage and increased apoptosis of hepatoblasts, and die by E12.5.
 
Interactions
Tab2 interacts with 379 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component cytoplasm, nucleus
Function metal ion binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (106)    Tissues (106)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 95
RT-PCR 11
cDNA source data(242)
External Resources: Allen Institute   Expression Atlas
Molecular
reagents
All nucleic(245) cDNA(243) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034128 (Evidence)
Ensembl Gene ModelENSMUSG00000015755 (Evidence)
Entrez Gene102631689, 68652
UniGene193041
DFCITC1626063, TC1600876, TC1574750
DoTSDT.91358810, DT.535223
NIA Mouse Gene IndexU031511
PDB3A9J
Consensus CDS ProjectCCDS23691.1
International Mouse Knockout Project StatusTab2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034128 VEGA Gene Model | MGI Sequence Detail 50578 C57BL/6J ±  kb
transcript OTTMUST00000086380 VEGA | MGI Sequence Detail 4380 Not Applicable 
polypeptide OTTMUSP00000046773 VEGA | MGI Sequence Detail 693 Not Applicable 

For the selected sequences
All sequences(41) UniProt(5)
Polymorphisms
SNPs within 2kb(148 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003892 Ubiquitin system component Cue
InterPro IPR001876 Zinc finger, RanBP2-type
Protein Ontology PR:000001772 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:212972 Ikeda Y, et al., TAK1 binding protein 2 is essential for liver protection from stressors. PLoS One. 2014;9(2):e88037
All references(56)
Other
accession IDs
MGI:2442803

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory