Automated description from the Alliance of Genome Resources (Release 8.3.0)
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; molecular adaptor activity; and zinc ion binding activity. Predicted to be involved in several processes, including non-canonical NF-kappaB signal transduction; positive regulation of canonical NF-kappaB signal transduction; and response to lipopolysaccharide. Predicted to act upstream of or within several processes, including intracellular signaling cassette; negative regulation of canonical NF-kappaB signal transduction; and protein K63-linked ubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of serine/threonine protein kinase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in cardiomyopathy; congenital heart disease; and ovary epithelial cancer. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2).
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