Letmd1 MGI Mouse Gene Detail - MGI:1915864

Symbol

Letmd1
Name

LETM1 domain containing 1
Synonyms

1110019O13Rik, HCCR1, HCCR-2

Feature Type

protein coding gene
IDs

MGI:1915864
NCBI Gene: 68614
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:100366904-100377045 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.31 cM
Mapping Data

2 experiments

SNPs within 2kb

299 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915864	protein coding gene	Chr15:100360302-100377133 (+)
129S1/SvImJ	ENSMUSG00200050784	protein coding gene	Chr15:97572426-97582625 (+)
A/J	ENSMUSG00195038600	protein coding gene	Chr15:97450270-97460411 (+)
AKR/J	ENSMUSG00220043743	protein coding gene	Chr15:97443502-97453644 (+)
BALB/cJ	ENSMUSG00180036130	protein coding gene	Chr15:97348248-97358451 (+)
C3H/HeJ	ENSMUSG00175040628	protein coding gene	Chr15:97630252-97640393 (+)
C57BL/6NJ	ENSMUSG00215050181	protein coding gene	Chr15:97405347-97415489 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020291	protein coding gene	Chr15:94166300-94177089 (+)
CAST/EiJ	ENSTCUG00005042759	protein coding gene	Chr15:96886754-96896999 (+)
CBA/J	ENSMUSG00210028625	protein coding gene	Chr15:97405096-97415296 (+)
DBA/2J	ENSMUSG00185038118	protein coding gene	Chr15:97449906-97460047 (+)
FVB/NJ	ENSMUSG00205025826	protein coding gene	Chr15:97154359-97164500 (+)
JF1/MsJ	ENSUMUG00000052550	protein coding gene	Chr15:96914611-96924883 (+)
LP/J	ENSMUSG00230039438	protein coding gene	Chr15:100795760-100805959 (+)
NOD/ShiLtJ	ENSMUSG00190046997	protein coding gene	Chr15:97381043-97391239 (+)
NZO/HlLtJ	ENSMUSG00225041587	protein coding gene	Chr15:100999173-101009371 (+)
PWK/PhJ	ENSLUMG00010038583	protein coding gene	Chr15:97117411-97127615 (+)
SPRET/EiJ	ENSMSPG00010048356	protein coding gene	Chr15:98938557-98948870 (+)
WSB/EiJ	ENSIUOG00005035846	protein coding gene	Chr15:97536196-97546394 (+)

Human Ortholog

LETMD1, LETM1 domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LETMD1, LETM1 domain containing 1
Synonyms

1110019O13Rik, HCCR, HCCR-1, HCCR1, HCCR-2, HCCR2, HCRR-2, SLC55A3
Links

HGNC:24241

NCBI Gene ID: 25875

UniProt: Q6P1Q0
Chr Location

12q13.12; chr12:51047962-51068958 (+) GRCh38

MGI Vertebrate Homology

Letmd1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LETMD1
Gene Tree

Letmd1

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References

1 with disease annotations

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Phenotype Summary

23 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

8
Gene trapped

3
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Letmd1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit impaired adaptive thermogenesis, whitened brown adipose tissue morphology, and increased susceptibility to diet-induced obesity and metabolic dysfunction.

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All GO Annotations

34
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

678
Tissues

18
cDNA Data

14
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase letmd1

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All Sequences

78
RefSeq

20
UniProt

2
CCDS

CCDS27838.1, CCDS88844.1, CCDS88845.1

Ensembl

ENSMUSG00000037353 (Evidence)
NCBI Gene

68614

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037353	Ensembl Gene Model \| MGI Sequence Detail	10142	C57BL/6J	± kb
transcript	ENSMUST00000037001	Ensembl \| MGI Sequence Detail	2502	Not Applicable
polypeptide	ENSMUSP00000037546	Ensembl \| MGI Sequence Detail	360	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009764 LETM1 domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR033122 LETM1-like, ribosome-binding domain

IPR044202 LETM1/MDM38-like

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All nucleic 14

cDNA 14

Microarray probesets 3

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MGI:2146040, MGI:2146262, MGI:2146267

Summaries

All 71

Developmental Gene Expression 4

Diseases 1

Gene Ontology 12

Phenotypes 37
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

TSS for Letmd1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133128	Chr15:100366856-100366874 (+)	-39 bp
Tssr133129	Chr15:100366937-100366956 (+)	43 bp
Tssr133130	Chr15:100366962-100367007 (+)	81 bp
Tssr133131	Chr15:100367671-100367682 (+)	773 bp
Tssr133132	Chr15:100376675-100376680 (+)	9,774 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29