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Cthrc1
Gene Detail
Symbol

Name
ID
Cthrc1
collagen triple helix repeat containing 1
MGI:1915838
Synonyms
1110014B07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 15
15.35 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:39076901-39087121 bp, + strand
From VEGA annotation of GRCm38

  10221 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16320  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CTHRC1
Gene Tree: Cthrc1

Human
homologs
CTHRC1, collagen triple helix repeat containing 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 115908
neXtProt AC: NX_Q96CG8

Human Chr (Location): 8q22.3; chr8:103371509-103383005 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CTHRC1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Adult mice homozygous for a null allele exhibit decreased bone, decreased osteoblast number and decreased bone formation. Mice homozygous for a different knock-out allele exhibit increased hepatocyte size, decreased cell density in the liver, hepatic steatosis and increased glycogen storage.
 
Phenotype Images(1)
Interactions
Cthrc1 interacts with 89 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell migration, cochlea morphogenesis, ...
Component collagen trimer, cytoplasm, ...
Function frizzled binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (619)    Tissues (155)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 29
RNA in situ 583
In situ reporter (knock in) 4
Northern blot 3
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cthrc1 ; ZFIN cthrc1a    NEW 
Molecular
reagents
All nucleic(19) cDNA(18) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000028035 (Evidence)
Ensembl Gene Model ENSMUSG00000054196 (Evidence)
Entrez Gene 68588 (Evidence)
UniGene 41556
DFCI TC1634588, TC1584151
DoTS DT.60109588, DT.91375067
NIA Mouse Gene Index U168181
Consensus CDS Project CCDS27442.1
International Mouse Phenotyping Consortium Status Cthrc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028035 VEGA Gene Model | MGI Sequence Detail 10221 C57BL/6J ±  kb
transcript OTTMUST00000069433 VEGA | MGI Sequence Detail 1164 Not Applicable 
polypeptide OTTMUSP00000035260 VEGA | MGI Sequence Detail 245 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(136 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
Protein Ontology PR:000006005 collagen triple helix repeat-containing protein 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:219223 Nagalakshmi VK, et al., microRNA-dependent temporal gene expression in the ureteric bud epithelium during mammalian kidney development. Dev Dyn. 2015 Mar;244(3):444-56
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory