Cthrc1
Gene Detail

Symbol Name ID

Cthrc1 collagen triple helix repeat containing 1 MGI:1915838

Synonyms

1110014B07Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 15

15.35 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:39076932-39087121 bp, + strand From VEGA annotation of GRCm38   10190 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:16320  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cthrc1

Human homologs

Human Homolog		CTHRC1, collagen triple helix repeat containing 1
NCBI Gene ID		115908
neXtProt AC		NX_Q96CG8
Human Chr (Location)		8q22.3; chr8:104383743-104395233 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CTHRC1

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Adult mice homozygous for a null allele exhibit decreased bone, decreased osteoblast number and decreased bone formation. Mice homozygous for a different knock-out allele exhibit increased hepatocyte size, decreased cell density in the liver, hepatic steatosis and increased glycogen storage.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cell migration, cochlea morphogenesis, ...
Component	collagen, cytoplasm, ...
Function	frizzled binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (619)    Tissues (154)    Images (50)
Theiler Stages: 9, 11, 13, 15, 17, 20, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	29
RNA in situ	583
In situ reporter (knock in)	4
Northern blot	3

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(18) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000028035 (Evidence)
Ensembl Gene Model	ENSMUSG00000054196 (Evidence)
Entrez Gene	68588 (Evidence)
UniGene	41556
DFCI	TC1584151, TC1634588
DoTS	DT.60109588, DT.91375067
NIA Mouse Gene Index	U168181
Consensus CDS Project	CCDS27442.1
International Mouse Knockout Project Status	Cthrc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028035	VEGA Gene Model | MGI Sequence Detail	10190	C57BL/6J
transcript	OTTMUST00000069433	VEGA | MGI Sequence Detail	1164	Not Applicable
polypeptide	OTTMUSP00000035260	VEGA | MGI Sequence Detail	245	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(100 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008160	Collagen triple helix repeat
Protein Ontology	PR:000006005	collagen triple helix repeat-containing protein 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:192096 Stohn JP, et al., Cthrc1, a novel circulating hormone regulating metabolism. PLoS One. 2012;7(10):e47142
All references(41)