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Rtn4
Gene Detail
 Symbol
Name
ID
Rtn4
reticulon 4
MGI:1915835
Synonyms 1110020G17Rik, C130026I10Rik, mKIAA0886, NgA, NOGO
Feature Type protein coding gene
Genetic Map
Chromosome 11
16.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:29692947-29744331 bp, + strand
From VEGA annotation of GRCm38

  51385 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10743  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Rtn4

Human
homologs
Human Homolog RTN4, reticulon 4
NCBI Gene ID 57142
neXtProt AC  NX_Q9NQC3
Human Synonyms  ASY, Nbla00271, Nbla10545, NI220/250, NOGO, NOGO-A, Nogo-B, Nogo-C, NOGOC, NSP, NSP-CL, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C, RTN-X
Human Chr (Location)  2p16.3; chr2:54972189-55112616 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(162) : Gene trapped(155) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant mice lacking the A and B isoforms are viable and one line shows enhanced regeneration and recovery after spinal cord injury. Different lines of mice lacking isoforms A, B, and C show varying phenotypes. Whereas some produce viable homozygotes, others are embryonic lethal.
 
Interactions
Rtn4 interacts with 366 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process angiogenesis, axonal fasciculation, ...
Component cell projection, cytoplasm, ...
Function poly(A) RNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (210)    Tissues (113)    Images (31)
Theiler Stages: 17, 21, 23, 27, 28
Assay TypeResults
RNA in situ 210
cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000005336 (Evidence)
Ensembl Gene ModelENSMUSG00000020458 (Evidence)
Entrez Gene68585 (Evidence)
DFCITC1573253, TC1585279, TC1586301, TC1591554, TC1598152, TC1614566
NIA Mouse Gene IndexU012413
PDB2KO2
Consensus CDS ProjectCCDS24499.1, CCDS24500.1, CCDS24501.1, CCDS24502.1, CCDS24503.1
International Mouse Knockout Project StatusRtn4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005336 VEGA Gene Model | MGI Sequence Detail 51385 C57BL/6J ±  kb
transcript OTTMUST00000011901 VEGA | MGI Sequence Detail 4618 Not Applicable 
polypeptide OTTMUSP00000005509 VEGA | MGI Sequence Detail 1162 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(10) UniProt(5)
Polymorphisms SNPs within 2kb(560 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003388 Reticulon
Protein Ontology PR:000014348 reticulon-4
References (Earliest) J:113876 GrandPre T, et al., Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature. 2000 Jan 27;403(6768):439-44
(Latest) J:207636 Kurowska Z, et al., Intracellular Nogo-A facilitates initiation of neurite formation in mouse midbrain neurons in vitro. Neuroscience. 2014 Jan 3;256:456-66
All references(111)
Other
accession IDs
MGI:2143973, MGI:2144005, MGI:2144056

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory