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Rtn4 Gene Detail
Summary
  • Symbol
    Rtn4
  • Name
    reticulon 4
  • Synonyms
    1110020G17Rik, C130026I10Rik, mKIAA0886, NgA, NOGO, Nogo-A, Nogo-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915835
    NCBI Gene: 68585
  • Gene Overview
    MyGene.info: RTN4
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:29692947-29744331 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 16.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    554 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915835
protein coding gene Chr11:29692898-29744414 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018111
protein coding gene Chr11:27715369-27775192 (+)
A/J MGP_AJ_G0018083
protein coding gene Chr11:26682234-26734703 (+)
AKR/J MGP_AKRJ_G0018048
protein coding gene Chr11:27558967-27610278 (+)
BALB/cJ MGP_BALBcJ_G0018051
protein coding gene Chr11:26886739-26942690 (+)
C3H/HeJ MGP_C3HHeJ_G0017865
protein coding gene Chr11:27470688-27524208 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018504
protein coding gene Chr11:28658593-28714007 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016161
protein coding gene Chr11:25313936-25365389 (+)
CAST/EiJ MGP_CASTEiJ_G0017427
protein coding gene Chr11:27533349-27587652 (+)
CBA/J MGP_CBAJ_G0017839
protein coding gene Chr11:30001002-30052077 (+)
DBA/2J MGP_DBA2J_G0017949
protein coding gene Chr11:26541455-26592783 (+)
FVB/NJ MGP_FVBNJ_G0017941
protein coding gene Chr11:26349476-26400596 (+)
LP/J MGP_LPJ_G0018021
protein coding gene Chr11:27964046-28018060 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017967
protein coding gene Chr11:31124652-31181522 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018544
protein coding gene Chr11:27663745-27721131 (+)
PWK/PhJ MGP_PWKPhJ_G0017209
protein coding gene Chr11:26631569-26684382 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017004
protein coding gene Chr11:27360571-27417981 (+)
WSB/EiJ MGP_WSBEiJ_G0017480
protein coding gene Chr11:27361143-27415140 (+)



Homology
more
  • Human Ortholog
    RTN4, reticulon 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RTN4, reticulon 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASY, Nbla00271, Nbla10545, NI220/250, NOGO, NSP, NSP-CL, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C, RTN-X
  • Links
    NCBI Gene ID: 57142
    neXtProt AC: NX_Q9NQC3
    UniProt: Q9NQC3

  • Chr Location
    2p16.1; chr2:54972187-55137831 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 8 alleles in 5 genetic backgrounds
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutant mice lacking the A and B isoforms are viable and one line shows enhanced regeneration and recovery after spinal cord injury. Different lines of mice lacking isoforms A, B, and C show varying phenotypes. Whereas some produce viable homozygotes, others are embryonic lethal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020458 Ensembl Gene Model | MGI Sequence Detail 51385 C57BL/6J ±  kb
    transcript ENSMUST00000102843 Ensembl | MGI Sequence Detail 4618 Not Applicable  
    polypeptide ENSMUSP00000099907 Ensembl | MGI Sequence Detail 1162 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 20
      Primer pair 4

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2143973, MGI:2144005, MGI:2144056
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 26
      Gene Ontology 23
      Phenotypes 59
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:265812 Berry S, et al., Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits. PLoS One. 2018;13(7):e0200896

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory