Gene Expression Literature Summary

• Symbol: Rtn4
• Name: reticulon 4
• ID: MGI:1915835

29 matching records from 29 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E8	E9.5	E10.5	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)								1		3	5		6	6		7	1	2	2		3	1	7
In situ RNA (section)									1	1	3		1	4		3	1				1		4
Immunohistochemistry (whole mount)												1	1
In situ RNA (whole mount)									1						1	2
In situ reporter (knock in)								1
Western blot										1	1		1	2		2	2						7
RT-PCR	1	1	1	1	1	1	1					1			1	1				1			4
cDNA clones														1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Rtn4  reticulon 4   (Synonyms: 1110020G17Rik, C130026I10Rik, mKIAA0886, NgA, NOGO, Nogo-A, Nogo-B)
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:204006 Beetz C, Koch N, Khundadze M, Zimmer G, Nietzsche S, Hertel N, Huebner AK, Mumtaz R, Schweizer M, Dirren E, Karle KN, Irintchev A, Alvarez V, Redies C, Westermann M, Kurth I, Deufel T, Kessels MM, Qualmann B, Hubner CA, A spastic paraplegia mouse model reveals REEP1-dependent ER shaping. J Clin Invest. 2013 Oct 1;123(10):4273-82
7*	J:244597 Cui W, Dai X, Marcho C, Han Z, Zhang K, Tremblay KD, Mager J, Towards Functional Annotation of the Preimplantation Transcriptome: An RNAi Screen in Mammalian Embryos. Sci Rep. 2016 Nov 21;6:37396
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:178079 Erblich B, Zhu L, Etgen AM, Dobrenis K, Pollard JW, Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits. PLoS One. 2011;6(10):e26317
2*	J:174479 Gil V, Bichler Z, Lee JK, Seira O, Llorens F, Bribian A, Morales R, Claverol-Tinture E, Soriano E, Sumoy L, Zheng B, Del Rio JA, Developmental expression of the oligodendrocyte myelin glycoprotein in the mouse telencephalon. Cereb Cortex. 2010 Aug;20(8):1769-79
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
6*	J:187589 Grunewald E, Tew KD, Porteous DJ, Thomson PA, Developmental expression of orphan g protein-coupled receptor 50 in the mouse brain. ACS Chem Neurosci. 2012 Jun 20;3(6):459-72
3*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
3	J:207636 Kurowska Z, Brundin P, Schwab ME, Li JY, Intracellular Nogo-A facilitates initiation of neurite formation in mouse midbrain neurons in vitro. Neuroscience. 2014 Jan 3;256:456-66
1*	J:86943 Lauren J, Airaksinen MS, Saarma M, Timmusk T, Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systems. Mol Cell Neurosci. 2003 Nov;24(3):581-94
4	J:161875 Mathis C, Schroter A, Thallmair M, Schwab ME, Nogo-a regulates neural precursor migration in the embryonic mouse cortex. Cereb Cortex. 2010 Oct;20(10):2380-90
6	J:91015 Mingorance A, Fontana X, Sole M, Burgaya F, Urena JM, Teng FY, Tang BL, Hunt D, Anderson PN, Bethea JR, Schwab ME, Soriano E, del Rio JA, Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesions. Mol Cell Neurosci. 2004 May;26(1):34-49
10	J:118055 Mingorance-Le Meur A, Zheng B, Soriano E, del Rio JA, Involvement of the Myelin-associated inhibitor Nogo-A in early cortical development and neuronal maturation. Cereb Cortex. 2007 Oct;17(10):2375-86
1	J:85925 Moreau-Fauvarque C, Kumanogoh A, Camand E, Jaillard C, Barbin G, Boquet I, Love C, Jones EY, Kikutani H, Lubetzki C, Dusart I, Chedotal A, The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion. J Neurosci. 2003 Oct 8;23(27):9229-39
2	J:161350 Nath AK, Krauthammer M, Li P, Davidov E, Butler LC, Copel J, Katajamaa M, Oresic M, Buhimschi I, Buhimschi C, Snyder M, Madri JA, Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects. PLoS One. 2009;4(1):e4221
2	J:139254 Pernet V, Joly S, Christ F, Dimou L, Schwab ME, Nogo-A and myelin-associated glycoprotein differently regulate oligodendrocyte maturation and myelin formation. J Neurosci. 2008 Jul 16;28(29):7435-44
11*	J:163856 Petrinovic MM, Duncan CS, Bourikas D, Weinman O, Montani L, Schroeter A, Maerki D, Sommer L, Stoeckli ET, Schwab ME, Neuronal Nogo-A regulates neurite fasciculation, branching and extension in the developing nervous system. Development. 2010 Aug 1;137(15):2539-50
1	J:197494 Philippidou P, Walsh CM, Aubin J, Jeannotte L, Dasen JS, Sustained Hox5 gene activity is required for respiratory motor neuron development. Nat Neurosci. 2012 Dec;15(12):1636-44
1*	J:174487 Rakic S, Davis C, Molnar Z, Nikolic M, Parnavelas JG, Role of p35/Cdk5 in preplate splitting in the developing cerebral cortex. Cereb Cortex. 2006 Jul;16 Suppl 1:i35-45
1*	J:174418 Sato Y, Iketani M, Kurihara Y, Yamaguchi M, Yamashita N, Nakamura F, Arie Y, Kawasaki T, Hirata T, Abe T, Kiyonari H, Strittmatter SM, Goshima Y, Takei K, Cartilage acidic protein-1B (LOTUS), an endogenous Nogo receptor antagonist for axon tract formation. Science. 2011 Aug 5;333(6043):769-73
4	J:79814 Tozaki H, Kawasaki T, Takagi Y, Hirata T, Expression of Nogo protein by growing axons in the developing nervous system. Brain Res Mol Brain Res. 2002 Aug 1;104(2):111
8	J:136994 Wang J, Chan CK, Taylor JS, Chan SO, Localization of Nogo and its receptor in the optic pathway of mouse embryos. J Neurosci Res. 2008 Jun;86(8):1721-33
8	J:158549 Wang J, Wang L, Zhao H, Chan SO, Localization of an axon growth inhibitory molecule Nogo and its receptor in the spinal cord of mouse embryos. Brain Res. 2010 Jan 8;1306:8-17
5	J:233613 Wang L, Wang J, Ma D, Taylor JS, Chan SO, Isoform-specific localization of Nogo protein in the optic pathway of mouse embryos. J Comp Neurol. 2016 Aug 1;524(11):2322-34
4	J:251974 Wang L, Yu C, Wang J, Leung P, Ma D, Zhao H, Taylor JSH, Chan SO, Nogo-B is the major form of Nogo at the floor plate and likely mediates crossing of commissural axons in the mouse spinal cord. J Comp Neurol. 2017 Sep 1;525(13):2915-2928
1	J:213512 Werber M, Wittler L, Timmermann B, Grote P, Herrmann BG, The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development. 2014 Jun;141(11):2325-30
3*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
1	J:343450 Zhou J, Shi Q, Ge YY, He W, Hu X, Xia W, Yan R, Reticulons 1 and 3 are essential for axonal growth and synaptic maintenance associated with intellectual development. Hum Mol Genet. 2023 Aug 7;32(16):2587-2599