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Tmem109 Gene Detail
Summary
  • Symbol
    Tmem109
  • Name
    transmembrane protein 109
  • Synonyms
    1110006I15Rik, MG23, mitsugumin23
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915789
    NCBI Gene: 68539
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:10870657-10881743 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 7.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915789
protein coding gene Chr19:10870657-10882001 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024860
protein coding gene Chr19:8245552-8258073 (-)
A/J MGP_AJ_G0024828
protein coding gene Chr19:7687524-7698921 (-)
AKR/J MGP_AKRJ_G0024803
protein coding gene Chr19:7987170-7998539 (-)
BALB/cJ MGP_BALBcJ_G0024828
protein coding gene Chr19:7732412-7743739 (-)
C3H/HeJ MGP_C3HHeJ_G0024594
protein coding gene Chr19:7876512-7891102 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025276
protein coding gene Chr19:8598231-8610728 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022703
protein coding gene Chr19:8104339-8115869 (-)
CAST/EiJ MGP_CASTEiJ_G0024067
protein coding gene Chr19:7529179-7541788 (-)
CBA/J MGP_CBAJ_G0024568
protein coding gene Chr19:8651519-8665972 (-)
DBA/2J MGP_DBA2J_G0024695
protein coding gene Chr19:7692033-7703881 (-)
FVB/NJ MGP_FVBNJ_G0024662
protein coding gene Chr19:7737512-7748836 (-)
LP/J MGP_LPJ_G0024782
protein coding gene Chr19:8196550-8210746 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024689
protein coding gene Chr19:8547219-8558859 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025324
protein coding gene Chr19:8010014-8021362 (-)
PWK/PhJ MGP_PWKPhJ_G0023812
protein coding gene Chr19:7146118-7157981 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023617
protein coding gene Chr19:7195346-7206781 (-)
WSB/EiJ MGP_WSBEiJ_G0024129
protein coding gene Chr19:7899563-7910994 (-)



Homology
more
  • Human Ortholog
    TMEM109, transmembrane protein 109
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TMEM109, transmembrane protein 109
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 79073
    neXtProt AC: NX_Q9BVC6
    UniProt: Q9BVC6

  • Chr Location
    11q12.2; chr11:60913899-60923443 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, overtly normal and exhibit normal thymocyte maturation; however, mutant thymocytes are less sensitive to DNA damage caused by gamma-irradiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 68539 NCBI Gene Model | MGI Sequence Detail 11087 C57BL/6J ±  kb
transcript NM_134142 RefSeq | MGI Sequence Detail 1943 Not Specified  
polypeptide Q3UBX0 UniProt | EBI | MGI Sequence Detail 243 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 135
    cDNA 134
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147461, MGI:2147782
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:160200 Nishi M, et al., Mitsugumin23, a novel transmembrane protein on endoplasmic reticulum and nuclear membranes. FEBS Lett. 1998 Aug 7;432(3):191-6
  • Latest
    J:195510 Yamashita A, et al., Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death. FEBS Lett. 2013 May 2;587(9):1299-303

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory