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Rpa1 Gene Detail
Summary
  • Symbol
    Rpa1
  • Name
    replication protein A1
  • Synonyms
    5031405K23Rik, 70kDa, RF-A, Rpa, RP-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915525
    NCBI Gene: 68275
  • Gene Overview
    MyGene.info: RPA1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:75300259-75348383 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.79 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    295 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915525
protein coding gene Chr11:75298166-75348383 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018708
protein coding gene Chr11:76041576-76093340 (-)
A/J MGP_AJ_G0018674
protein coding gene Chr11:73213941-73264040 (-)
AKR/J MGP_AKRJ_G0018644
protein coding gene Chr11:75429599-75479663 (-)
BALB/cJ MGP_BALBcJ_G0018648
protein coding gene Chr11:73581830-73632923 (-)
C3H/HeJ MGP_C3HHeJ_G0018461
protein coding gene Chr11:75442914-75492919 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019099
protein coding gene Chr11:78414838-78465739 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016734
protein coding gene Chr11:70226752-70277148 (-)
CAST/EiJ MGP_CASTEiJ_G0018015
protein coding gene Chr11:75842079-75894811 (-)
CBA/J MGP_CBAJ_G0018431
protein coding gene Chr11:81846974-81902472 (-)
DBA/2J MGP_DBA2J_G0018540
protein coding gene Chr11:72823629-72873755 (-)
FVB/NJ MGP_FVBNJ_G0018530
protein coding gene Chr11:72383541-72435111 (-)
LP/J MGP_LPJ_G0018611
protein coding gene Chr11:76627675-76680948 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018556
protein coding gene Chr11:82436883-82492638 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019139
protein coding gene Chr11:75628008-75678084 (-)
PWK/PhJ MGP_PWKPhJ_G0017786
protein coding gene Chr11:73514011-73566198 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017577
protein coding gene Chr11:75192525-75242430 (-)
WSB/EiJ MGP_WSBEiJ_G0018068
protein coding gene Chr11:75436727-75494803 (-)



Homology
more
  • Human Ortholog
    RPA1, replication protein A1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RPA1, replication protein A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSSB, MST075, REPA1, RF-A, RP-A, RPA70
  • Links
    NCBI Gene ID: 6117
    neXtProt AC: NX_P27694
    UniProt: P27694

  • Chr Location
    17p13.3; chr17:1829979-1899554 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality before implantation and impaired cell proliferation. Heterozygous null mice display decreased survival, chromosomal instability, impaired double strand break repair, and develop lymphomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68275 NCBI Gene Model | MGI Sequence Detail 48125 C57BL/6J ±  kb
    transcript NM_001164223 RefSeq | MGI Sequence Detail 3121 C57BL/6  
    polypeptide Q8VEE4 UniProt | EBI | MGI Sequence Detail 623 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR012340 Nucleic acid-binding, OB-fold
      IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
      IPR013955 Replication factor A, C-terminal
      IPR004591 Replication factor A protein 1
      IPR007199 Replication factor-A protein 1, N-terminal
      IPR031657 Replication protein A, OB domain
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 2
      cDNA 23

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1194911, MGI:2144032, MGI:2144576
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 9
      Gene Ontology 18
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:238653 Taniguchi JB, et al., RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair. Hum Mol Genet. 2016 Oct 15;25(20):4432-4447

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory