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Rpa1 Gene Detail
Summary
  • Symbol
    Rpa1
  • Name
    replication protein A1
  • Synonyms
    5031405K23Rik, 70kDa, RF-A, Rpa, RP-A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915525
    NCBI Gene: 68275
  • Gene Overview
    MyGene.info: RPA1
Location & Maps
more
  • Sequence Map
    Chr11:75298166-75348324 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      50159 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.79 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RPA1, replication protein A1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RPA1, replication protein A1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HSSB, MST075, REPA1, RF-A, RP-A, RPA70
  • Links
    NCBI Gene ID: 6117
    neXtProt AC: NX_P27694

  • Chr Location
    17p13.3; chr17:1829979-1899554 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    50
  • Chemically induced (other)
    1
  • Gene trapped
    44
  • Targeted
    5
  • Genomic Mutations
    2 involving Rpa1
  • Incidental Mutations
Homozygous null mice display embryonic lethality before implantation and impaired cell proliferation. Heterozygous null mice display decreased survival, chromosomal instability, impaired double strand break repair, and develop lymphomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006199 VEGA Gene Model | MGI Sequence Detail 50159 C57BL/6J ±  kb
transcript OTTMUST00000013978 VEGA | MGI Sequence Detail 2942 Not Applicable  
polypeptide OTTMUSP00000006493 VEGA | MGI Sequence Detail 644 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    298 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014170 replication protein A 70 kDa DNA-binding subunit
  • InterPro Domains
    IPR012340 Nucleic acid-binding, OB-fold
    IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
    IPR013955 Replication factor A, C-terminal
    IPR004591 Replication factor A protein 1
    IPR007199 Replication factor-A protein 1, N-terminal
    IPR031657 Replication protein A, OB domain
Molecular
Reagents
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  • All nucleic 24
    Genomic 2
    cDNA 22

    Microarray probesets 5
Other
Accession IDs
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MGI:1194911, MGI:2144032, MGI:2144576
References
more
  • Summaries
    All 57
    Developmental Gene Expression 9
    Gene Ontology 16
    Phenotypes 18
  • Earliest
    J:40754 Hamilton BA, et al., The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May;18(5):711-22
  • Latest
    J:229524 Robert T, et al., The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation. Science. 2016 Feb 26;351(6276):943-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory