About   Help   FAQ
Rpa1
Gene Detail
Symbol

Name
ID
Rpa1
replication protein A1
MGI:1915525
Synonyms
5031405K23Rik, 70kDa, RF-A, Rpa, RP-A
Feature Type
protein coding gene
Genetic Map
Chromosome 11
45.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:75298166-75348324 bp, - strand
From VEGA annotation of GRCm38

  50159 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2208  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: replication protein A, RPA70 subunit
Gene Tree: Rpa1

Human
homologs
Human Homolog RPA1, replication protein A1, 70kDa
NCBI Gene ID 6117
neXtProt AC  NX_P27694
Human Synonyms  HSSB, MST075, REPA1, RF-A, RP-A, RPA70
Human Chr (Location)  17p13.3; chr17:1829979-1899554 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(48) : Gene trapped(44) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality before implantation and impaired cell proliferation. Heterozygous null mice display decreased survival, chromosomal instability, impaired double strand break repair, and develop lymphomas.
 
Interactions
Rpa1 interacts with 314 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process base-excision repair, cellular response to DNA damage stimulus, ...
Component condensed chromosome, condensed nuclear chromosome, ...
Function chromatin binding, damaged DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (82)    Tissues (10)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 82
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(2) cDNA(22)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000006199 (Evidence)
Ensembl Gene ModelENSMUSG00000000751 (Evidence)
Entrez Gene68275 (Evidence)
DFCITC1573971
DoTSDT.101392087, DT.99866144, DT.97388985, DT.97359438
NIA Mouse Gene IndexU033076
Consensus CDS ProjectCCDS25044.1, CCDS48847.1
International Mouse Knockout Project StatusRpa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006199 VEGA Gene Model | MGI Sequence Detail 50159 C57BL/6J ±  kb
transcript OTTMUST00000013978 VEGA | MGI Sequence Detail 2942 Not Applicable 
polypeptide OTTMUSP00000006493 VEGA | MGI Sequence Detail 644 Not Applicable 

For the selected sequences
All sequences(117) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(300 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR004365 Nucleic acid binding, OB-fold, tRNA/helicase-type
InterPro IPR013955 Replication factor A, C-terminal
InterPro IPR007199 Replication factor-A protein 1, N-terminal
InterPro IPR004591 Replication factor-a protein 1 Rpa1
Protein Ontology PR:000014170 replication protein A 70 kDa DNA-binding subunit
References
(Earliest) J:40754 Hamilton BA, et al., The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression. Neuron. 1997 May;18(5):711-22
(Latest) J:211663 Fukuda T, et al., STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis. EMBO J. 2014 Jun 2;33(11):1243-55
All references(59)
Other
accession IDs
MGI:1194911, MGI:2144032, MGI:2144576

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory