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Rnaseh2c Gene Detail
Summary
  • Symbol
    Rnaseh2c
  • Name
    ribonuclease H2, subunit C
  • Synonyms
    1500026D16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915459
    NCBI Gene: 68209
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5601873-5602959 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.34 cM, cytoband A
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915459
protein coding gene Chr19:5601873-5603439 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024717
protein coding gene Chr19:2583699-2585265 (+)
A/J MGP_AJ_G0024683
protein coding gene Chr19:2439168-2440734 (+)
AKR/J MGP_AKRJ_G0024656
protein coding gene Chr19:2503787-2505353 (+)
BALB/cJ MGP_BALBcJ_G0024683
protein coding gene Chr19:2433286-2434852 (+)
C3H/HeJ MGP_C3HHeJ_G0024451
protein coding gene Chr19:2521624-2523190 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025130
protein coding gene Chr19:2645980-2647546 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022560
protein coding gene Chr19:2345501-2347066 (+)
CAST/EiJ MGP_CASTEiJ_G0023923
protein coding gene Chr19:2542624-2544190 (+)
CBA/J MGP_CBAJ_G0024423
protein coding gene Chr19:2762864-2764430 (+)
DBA/2J MGP_DBA2J_G0024550
protein coding gene Chr19:2435422-2436988 (+)
FVB/NJ MGP_FVBNJ_G0024516
protein coding gene Chr19:2429220-2430786 (+)
LP/J MGP_LPJ_G0024636
protein coding gene Chr19:2556163-2557729 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024546
protein coding gene Chr19:2615515-2617081 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025178
protein coding gene Chr19:2522313-2523879 (+)
PWK/PhJ MGP_PWKPhJ_G0023669
protein coding gene Chr19:2458049-2459619 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023474
protein coding gene Chr19:2505718-2507286 (+)
WSB/EiJ MGP_WSBEiJ_G0023985
protein coding gene Chr19:2534543-2536109 (+)



Homology
more
  • Human Ortholog
    RNASEH2C, ribonuclease H2 subunit C
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RNASEH2C, ribonuclease H2 subunit C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGS3, AYP1
  • Links
    NCBI Gene ID: 84153
    neXtProt AC: NX_Q8TDP1
    UniProt: Q8TDP1

  • Chr Location
    11q13.1; chr11:65717673-65720938 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human RNASEH2C associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous are small at E9.5 and are not recovered thereafter.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68209 NCBI Gene Model | MGI Sequence Detail 1087 C57BL/6J ±  kb
    transcript NM_026616 RefSeq | MGI Sequence Detail 646 C57BL/6  
    polypeptide Q9CQ18 UniProt | EBI | MGI Sequence Detail 166 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 66

      Microarray probesets 4
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:198961 Ghodgaonkar MM, et al., Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. Mol Cell. 2013 May 9;50(3):323-32

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory