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Itfg2 Gene Detail
Summary
  • Symbol
    Itfg2
  • Name
    integrin alpha FG-GAP repeat containing 2
  • Synonyms
    2700050P07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915450
    NCBI Gene: 101142
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:128386407-128401873 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 62.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    46 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915450
protein coding gene Chr6:128386407-128401894 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031326
protein coding gene Chr6:132018829-132036107 (-)
A/J MGP_AJ_G0031297
protein coding gene Chr6:126952233-126969612 (-)
AKR/J MGP_AKRJ_G0031225
protein coding gene Chr6:130369078-130386241 (-)
BALB/cJ MGP_BALBcJ_G0031304
protein coding gene Chr6:126527434-126542437 (-)
C3H/HeJ MGP_C3HHeJ_G0031028
protein coding gene Chr6:130508698-130527507 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031763
protein coding gene Chr6:135450187-135466989 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028909
protein coding gene Chr6:124161751-124175468 (-)
CAST/EiJ MGP_CASTEiJ_G0030409
protein coding gene Chr6:130801441-130820550 (-)
CBA/J MGP_CBAJ_G0030989
protein coding gene Chr6:140675993-140698061 (-)
DBA/2J MGP_DBA2J_G0031145
protein coding gene Chr6:125850088-125868048 (-)
FVB/NJ MGP_FVBNJ_G0031095
protein coding gene Chr6:124778155-124793499 (-)
LP/J MGP_LPJ_G0031225
protein coding gene Chr6:132137224-132152539 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031133
protein coding gene Chr6:144513974-144532620 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031796
protein coding gene Chr6:130383904-130400066 (-)
PWK/PhJ MGP_PWKPhJ_G0030124
protein coding gene Chr6:124144452-124160699 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029953
protein coding gene Chr6:128505772-128521956 (-)
WSB/EiJ MGP_WSBEiJ_G0030494
protein coding gene Chr6:130780287-130798941 (-)



Homology
more
  • Human Ortholog
    ITFG2, integrin alpha FG-GAP repeat containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITFG2, integrin alpha FG-GAP repeat containing 2
  • Synonyms
    FGGAP1, KICS3, MDS028
  • Links
    NCBI Gene ID: 55846
    neXtProt AC: NX_Q969R8
    UniProt: Q969R8

  • Chr Location
    12p13.33; chr12:2812622-2859791 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit abnormal B cell differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 101142 NCBI Gene Model | MGI Sequence Detail 15467 C57BL/6J ±  kb
    transcript NM_133927 RefSeq | MGI Sequence Detail 2314 Not Specified  
    polypeptide Q91WI7 UniProt | EBI | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141460
    References
    more
    • Summaries
      All 30
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:205951 Al-Shami A, et al., Integrin-alpha FG-GAP repeat-containing protein 2 is critical for normal B cell differentiation and controls disease development in a lupus model. J Immunol. 2013 Oct 1;191(7):3789-98

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory