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Itfg2 Gene Detail
Summary
  • Symbol
    Itfg2
  • Name
    integrin alpha FG-GAP repeat containing 2
  • Synonyms
    2700050P07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915450
    NCBI Gene: 101142
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:128409444-128424931 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 62.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    46 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915450
protein coding gene Chr6:128409444-128424941 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031326
protein coding gene Chr6:132018829-132036107 (-)
A/J MGP_AJ_G0031297
protein coding gene Chr6:126952233-126969612 (-)
AKR/J MGP_AKRJ_G0031225
protein coding gene Chr6:130369078-130386241 (-)
BALB/cJ MGP_BALBcJ_G0031304
protein coding gene Chr6:126527434-126542437 (-)
C3H/HeJ MGP_C3HHeJ_G0031028
protein coding gene Chr6:130508698-130527507 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031763
protein coding gene Chr6:135450187-135466989 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028909
protein coding gene Chr6:124161751-124175468 (-)
CAST/EiJ MGP_CASTEiJ_G0030409
protein coding gene Chr6:130801441-130820550 (-)
CBA/J MGP_CBAJ_G0030989
protein coding gene Chr6:140675993-140698061 (-)
DBA/2J MGP_DBA2J_G0031145
protein coding gene Chr6:125850088-125868048 (-)
FVB/NJ MGP_FVBNJ_G0031095
protein coding gene Chr6:124778155-124793499 (-)
LP/J MGP_LPJ_G0031225
protein coding gene Chr6:132137224-132152539 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031133
protein coding gene Chr6:144513974-144532620 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031796
protein coding gene Chr6:130383904-130400066 (-)
PWK/PhJ MGP_PWKPhJ_G0030124
protein coding gene Chr6:124144452-124160699 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029953
protein coding gene Chr6:128505772-128521956 (-)
WSB/EiJ MGP_WSBEiJ_G0030494
protein coding gene Chr6:130780287-130798941 (-)



Homology
more
  • Human Ortholog
    ITFG2, integrin alpha FG-GAP repeat containing 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ITFG2, integrin alpha FG-GAP repeat containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FGGAP1, MDS028
  • Links
    NCBI Gene ID: 55846
    neXtProt AC: NX_Q969R8
    UniProt: Q969R8

  • Chr Location
    12p13.33; chr12:2812621-2832217 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10211
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ITFG2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    10 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit abnormal B cell differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001518 Ensembl Gene Model | MGI Sequence Detail 15488 C57BL/6J ±  kb
transcript ENSMUST00000001559 Ensembl | MGI Sequence Detail 2320 Not Applicable  
polypeptide ENSMUSP00000001559 Ensembl | MGI Sequence Detail 443 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 5
Other
Accession IDs
less
MGI:2141460
References
more
  • Summaries
    All 27
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:205951 Al-Shami A, et al., Integrin-alpha FG-GAP repeat-containing protein 2 is critical for normal B cell differentiation and controls disease development in a lupus model. J Immunol. 2013 Oct 1;191(7):3789-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory