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Eif3h Gene Detail
Summary
  • Symbol
    Eif3h
  • Name
    eukaryotic translation initiation factor 3, subunit H
  • Synonyms
    1110008A16Rik, 9430017H16Rik, EIF3-gamma, EIF3-P40, Eif3s3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915385
    NCBI Gene: 68135
  • Gene Overview
    MyGene.info: EIF3H
Location & Maps
more
  • Sequence Map
    Chr15:51786558-51865481 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      78924 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 19.42 cM, cytoband D1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EIF3H, eukaryotic translation initiation factor 3 subunit H
  • Vertebrate Orthologs
    12
  • Human Ortholog
    EIF3H, eukaryotic translation initiation factor 3 subunit H
    Orthology source: HGNC, HomoloGene
  • Synonyms
    eIF3-gamma, eIF3-p40, EIF3S3
  • Links
    NCBI Gene ID: 8667
    neXtProt AC: NX_O15372

  • Chr Location
    8q24.11; chr8:116644816-116755823 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2785
    1 human;1 mouse;2 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: EIF3H
  • Gene Tree
Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    46
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    2
  • Gene trapped
    39
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Eif3h
  • Incidental Mutations
Mice homozygous for an ENU-induced allele exhibit embryonic lethality. Heterozygous mice exhibit enhanced variegation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022312 Ensembl Gene Model | MGI Sequence Detail 78924 C57BL/6J ±  kb
transcript ENSMUST00000022925 Ensembl | MGI Sequence Detail 1253 Not Applicable  
polypeptide ENSMUSP00000022925 Ensembl | MGI Sequence Detail 352 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    466 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000006980 eukaryotic translation initiation factor 3 subunit H
  • InterPro Domains
    IPR027524 Eukaryotic translation initiation factor 3 subunit H
    IPR000555 JAB1/MPN/MOV34 metalloenzyme domain
Molecular
Reagents
less
  • All nucleic 392
    cDNA 390
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:1915828
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 5
    Phenotypes 22
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:204915 Zeng L, et al., The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. J Biol Chem. 2013 Oct 18;288(42):30087-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory