About   Help   FAQ
Eif3h Gene Detail
Summary
  • Symbol
    Eif3h
  • Name
    eukaryotic translation initiation factor 3, subunit H
  • Synonyms
    1110008A16Rik, 9430017H16Rik, EIF3-gamma, EIF3-P40, Eif3s3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915385
    NCBI Gene: 68135
  • Gene Overview
    MyGene.info: EIF3H
Location & Maps
more
  • Sequence Map
    Chr15:51786563-51865461 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      78899 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 19.42 cM, cytoband D1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EIF3H, eukaryotic translation initiation factor 3 subunit H
  • Vertebrate Orthologs
    12
  • Human Ortholog
    EIF3H, eukaryotic translation initiation factor 3 subunit H
    Orthology source: HomoloGene, HGNC
  • Synonyms
    eIF3-gamma, eIF3-p40, EIF3S3
  • Links
    NCBI Gene ID: 8667
    neXtProt AC: NX_O15372
    UniProt: O15372

  • Chr Location
    8q23.3-q24.11; chr8:116644816-116755823 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2785
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EIF3H
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit embryonic lethality. Heterozygous mice exhibit enhanced variegation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68135 NCBI Gene Model | MGI Sequence Detail 78899 C57BL/6J ±  kb
transcript NM_080635 RefSeq | MGI Sequence Detail 1254 Not Specified  
polypeptide Q91WK2 UniProt | EBI | MGI Sequence Detail 352 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    465 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000006980 eukaryotic translation initiation factor 3 subunit H
  • InterPro Domains
    IPR027524 Eukaryotic translation initiation factor 3 subunit H
    IPR000555 JAB1/MPN/MOV34 metalloenzyme domain
Molecular
Reagents
less
  • All nucleic 392
    cDNA 390
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:1915828
References
more
  • Summaries
    All 53
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 22
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:204915 Zeng L, et al., The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control. J Biol Chem. 2013 Oct 18;288(42):30087-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/18/2017
MGI 6.08
The Jackson Laboratory