Eif3h MGI Mouse Gene Detail - MGI:1915385 - eukaryotic translation initiation factor 3, subunit H

Symbol

Eif3h
Name

eukaryotic translation initiation factor 3, subunit H
Synonyms

1110008A16Rik, 9430017H16Rik, EIF3-gamma, EIF3-P40, Eif3s3

Feature Type

protein coding gene
IDs

MGI:1915385
NCBI Gene: 68135
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:51649956-51728901 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 19.42 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

2255 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915385	protein coding gene	Chr15:51649954-51728919 (-)
129S1/SvImJ	ENSMUSG00200019335	protein coding gene	Chr15:48645274-48724271 (-)
A/J	ENSMUSG00195005559	protein coding gene	Chr15:48648223-48727215 (-)
AKR/J	ENSMUSG00220017835	protein coding gene	Chr15:48648164-48727160 (-)
BALB/cJ	ENSMUSG00180004587	protein coding gene	Chr15:48613440-48692425 (-)
C3H/HeJ	ENSMUSG00175020347	protein coding gene	Chr15:48835088-48913892 (-)
C57BL/6NJ	ENSMUSG00215003203	protein coding gene	Chr15:48607955-48686949 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019780	protein coding gene	Chr15:45782980-45863856 (-)
CAST/EiJ	ENSTCUG00005013800	protein coding gene	Chr15:48508216-48586992 (-)
CBA/J	ENSMUSG00210026449	protein coding gene	Chr15:48716197-48794992 (-)
DBA/2J	ENSMUSG00185012995	protein coding gene	Chr15:48687447-48766247 (-)
FVB/NJ	ENSMUSG00205012648	protein coding gene	Chr15:48503656-48582524 (-)
JF1/MsJ	ENSUMUG00000018797	protein coding gene	Chr15:48511366-48590310 (-)
LP/J	ENSMUSG00230014120	protein coding gene	Chr15:52006047-52085059 (-)
NOD/ShiLtJ	ENSMUSG00190008281	protein coding gene	Chr15:48662661-48741647 (-)
NZO/HlLtJ	ENSMUSG00225028355	protein coding gene	Chr15:52319322-52398318 (-)
PWK/PhJ	ENSLUMG00010012245	protein coding gene	Chr15:48738915-48817849 (-)
SPRET/EiJ	ENSMSPG00010006779	protein coding gene	Chr15:49715878-49795362 (-)
WSB/EiJ	ENSIUOG00005020900	protein coding gene	Chr15:48679063-48758015 (-)

Human Ortholog

EIF3H, eukaryotic translation initiation factor 3 subunit H

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EIF3H, eukaryotic translation initiation factor 3 subunit H
Synonyms

eIF3-gamma, eIF3-p40, EIF3S3
Links

HGNC:3273

NCBI Gene ID: 8667

UniProt: O15372
Chr Location

8q23.3-q24.11; chr8:116642130-116766925 (-) GRCh38

MGI Vertebrate Homology

Eif3h stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: EIF3H
Gene Tree

Eif3h

Diseases

3 with human EIF3H associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358
				prostate carcinoma IDs prostate carcinoma DOID:10286 EFO:0001663 KEGG:05215 NCI:C4863 UMLS_CUI:C0600139

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 3 alleles in 2 genetic backgrounds
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (ENU)

2
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

31
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Eif3h
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

Mice homozygous for an ENU-induced allele exhibit embryonic lethality. Heterozygous mice exhibit enhanced variegation.

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All GO Annotations

33
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

663
Tissues

45
cDNA Data

390
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eif3h

ZFIN eif3ha, eif3hb

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All Sequences

65
RefSeq

10
UniProt

6
CCDS

CCDS27461.1

Ensembl

ENSMUSG00000022312 (Evidence)
NCBI Gene

68135

			Length	Strain/Species	Flank
genomic	68135	NCBI Gene Model \| MGI Sequence Detail	78946	C57BL/6J	± kb
transcript	NM_080635	RefSeq \| MGI Sequence Detail	1275	C57BL/6
polypeptide	Q91WK2	UniProt \| EBI \| MGI Sequence Detail	352	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000006980 eukaryotic translation initiation factor 3 subunit H

(term hierarchy)
InterPro Domains

IPR045810 eIF3h, C-terminal

IPR027524 Eukaryotic translation initiation factor 3 subunit H

IPR000555 JAB1/MPN/MOV34 metalloenzyme domain

IPR050242 JAMM/MPN+ metalloenzymes, peptidase M67A

IPR037518 MPN domain
GlyGen

Q91WK2 1 site, 1 O-linked glycan (1 site)

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All nucleic 394

cDNA 391

Primer pair 3

Antibodies 2

Microarray probesets 2

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MGI:1915828

Summaries

All 68

Developmental Gene Expression 8

Diseases 1

Gene Ontology 9

Phenotypes 27
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:346383 Jin H, et al., The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression. Nat Commun. 2024 Mar 21;15(1):2551

TSS for Eif3h:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134287	Chr15:51728894-51728913 (-)	-3 bp
Tssr134286	Chr15:51728844-51728870 (-)	44 bp
Tssr134285	Chr15:51653675-51653693 (-)	75,217 bp
Tssr134284	Chr15:51653646-51653664 (-)	75,246 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24