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Cops8
Gene Detail
Symbol

Name
ID
Cops8
COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana)
MGI:1915363
Synonyms
9430009J09Rik, Csn8, Sgn8
Feature Type
protein coding gene
Genetic Map
Chromosome 1
45.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:90602981-90613341 bp, + strand
From VEGA annotation of GRCm38

  10361 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4882  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: COPS8
Protein SuperFamily: COP9 signalosome complex, subunit 8
Gene Tree: Cops8

Human
homologs
COPS8, COP9 signalosome subunit 8
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10920
neXtProt AC: NX_Q99627

Human Synonyms: COP9, CSN8, SGN8

Human Chr (Location): 2q37.3; chr2:237085441-237098846 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a null allele exhibit embryonic lethality, reduced embryonic size and growth, and reduced to absent outgrowth of the inner cell mass of E3.5 embryos.
 
Interactions
Cops8 interacts with 157 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process activation of NF-kappaB-inducing kinase activity, cullin deneddylation, ...
Component COP9 signalosome, cytoplasm, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (9)    Tissues (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
Western blot 1
cDNA source data(156)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cops8 ; ZFIN cops8    NEW 
Molecular
reagents
All nucleic(156) cDNA(156)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000048401 (Evidence)
Ensembl Gene Model ENSMUSG00000034432 (Evidence)
Entrez Gene 108679 (Evidence)
UniGene 119177
DFCI TC1590738, TC1571929
DoTS DT.101281313, DT.536370, DT.94345256, DT.97412240
NIA Mouse Gene Index U000593
Consensus CDS Project CCDS15153.1
International Mouse Phenotyping Consortium Status Cops8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048401 VEGA Gene Model | MGI Sequence Detail 10361 C57BL/6J ±  kb
transcript OTTMUST00000124087 VEGA | MGI Sequence Detail 2287 Not Applicable 
polypeptide OTTMUSP00000067581 VEGA | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000005746 COP9 signalosome complex subunit 8
References
(Earliest) J:50270 Wei N, et al., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 1998 Jul 30-Aug 13;8(16):919-22
(Latest) J:204316 Lei D, et al., Hepatic deficiency of COP9 signalosome subunit 8 induces ubiquitin-proteasome system impairment and Bim-mediated apoptosis in murine livers. PLoS One. 2013;8(7):e67793
All references(41)
Other
accession IDs
MGI:2138079

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory