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Sdhaf4 Gene Detail
Summary
  • Symbol
    Sdhaf4
  • Name
    succinate dehydrogenase complex assembly factor 4
  • Synonyms
    1110058L19Rik, 1700001E18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915252
    NCBI Gene: 68002
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:23995939-24005640 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 9.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915252
protein coding gene Chr1:23995939-24005656 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015887
protein coding gene Chr1:21831290-21841007 (-)
A/J MGP_AJ_G0015868
protein coding gene Chr1:21393940-21403642 (-)
AKR/J MGP_AKRJ_G0015825
protein coding gene Chr1:21623518-21633235 (-)
BALB/cJ MGP_BALBcJ_G0015824
protein coding gene Chr1:21136527-21146217 (-)
C3H/HeJ MGP_C3HHeJ_G0015658
protein coding gene Chr1:21619491-21629974 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016278
protein coding gene Chr1:22811495-22821212 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013997
protein coding gene Chr1:19469734-19479809 (-)
CAST/EiJ MGP_CASTEiJ_G0015237
protein coding gene Chr1:21730566-21740242 (-)
CBA/J MGP_CBAJ_G0015630
protein coding gene Chr1:23360922-23370624 (-)
DBA/2J MGP_DBA2J_G0015729
protein coding gene Chr1:20881113-20890815 (-)
FVB/NJ MGP_FVBNJ_G0015733
protein coding gene Chr1:20641704-20651406 (-)
LP/J MGP_LPJ_G0015801
protein coding gene Chr1:22026640-22036357 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015753
protein coding gene Chr1:24369177-24378879 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016325
protein coding gene Chr1:21510604-21520306 (-)
PWK/PhJ MGP_PWKPhJ_G0015020
protein coding gene Chr1:20642759-20652583 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014801
protein coding gene Chr1:21636068-21645813 (-)
WSB/EiJ MGP_WSBEiJ_G0015300
protein coding gene Chr1:21452197-21462266 (-)



Homology
more
  • Human Ortholog
    SDHAF4, succinate dehydrogenase complex assembly factor 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SDHAF4, succinate dehydrogenase complex assembly factor 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C6orf57, Sdh8
  • Links
    NCBI Gene ID: 135154
    neXtProt AC: NX_Q5VUM1
    UniProt: Q5VUM1

  • Chr Location
    6q13; chr6:70566922-70588903 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32661
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SDHAF4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Sdhaf4
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68002 NCBI Gene Model | MGI Sequence Detail 9702 C57BL/6J ±  kb
transcript NM_026503 RefSeq | MGI Sequence Detail 675 C57BL/6  
polypeptide Q8BTE0 UniProt | EBI | MGI Sequence Detail 104 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR012875 Protein of unknown function DUF1674
Molecular
Reagents
less
  • All nucleic 45
    cDNA 45

    Microarray probesets 3
Other
Accession IDs
less
MGI:1922711, MGI:2138344
References
more
  • Summaries
    All 28
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:215483 Van Vranken JG, et al., SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Cell Metab. 2014 Aug 5;20(2):241-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory