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Mpc1
Gene Detail
Symbol

Name
ID
Mpc1
mitochondrial pyruvate carrier 1
MGI:1915240
Synonyms
0610006G08Rik, 3830411I18Rik, Brp44l
Feature Type
protein coding gene
Genetic Map
Chromosome 17
4.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:8282904-8297661 bp, + strand
From VEGA annotation of GRCm38

  14758 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9384  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MPC1
Gene Tree: Mpc1

Human
homologs
MPC1, mitochondrial pyruvate carrier 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51660
neXtProt AC: NX_Q9Y5U8

Human Synonyms: BRP44L, CGI-129, dJ68L15.3, MPYCD

Human Chr (Location): 6q27; chr6:166364919-166383013 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MPC1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Interactions
Mpc1 interacts with 149 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process mitochondrial pyruvate transport, pyruvate metabolic process, ...
Component cell, integral component of membrane, ...
Function pyruvate transmembrane transporter activity
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (120)    Tissues (43)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 120
cDNA source data(173)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase mpc1 ; ZFIN mpc1    NEW 
Molecular
reagents
All nucleic(175) cDNA(174) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000032995 (Evidence)
Ensembl Gene Model ENSMUSG00000023861 (Evidence)
Entrez Gene 55951 (Evidence)
UniGene 288510
DFCI TC1774406, TC1573511, TC1732055, TC1628215
DoTS DT.99867565, DT.94202365, DT.91337836, DT.537241, DT.101223813
NIA Mouse Gene Index U017467, U088289
Consensus CDS Project CCDS49944.1
International Mouse Phenotyping Consortium Status Mpc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032995 VEGA Gene Model | MGI Sequence Detail 14758 C57BL/6J ±  kb
transcript OTTMUST00000082288 VEGA | MGI Sequence Detail 961 Not Applicable 
polypeptide OTTMUSP00000044089 VEGA | MGI Sequence Detail 167 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(4) UniProt(8)
Polymorphisms
SNPs within 2kb(135 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005336 Uncharacterised protein family UPF0041
Protein Ontology PR:000004821 brain protein 44-like protein
References
(Earliest) J:58544 Trachtulec Z, et al., Synteny of orthologous genes conserved in mammals, snake, fly, nematode, and fission yeast. Mamm Genome. 2001 Mar;12(3):227-31
(Latest) J:185358 Herzig S, et al., Identification and functional expression of the mitochondrial pyruvate carrier. Science. 2012 Jul 6;337(6090):93-6
All references(35)
Other
accession IDs
MGI:1917947

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory