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Mpc1 Gene Detail
Summary
  • Symbol
    Mpc1
  • Name
    mitochondrial pyruvate carrier 1
  • Synonyms
    0610006G08Rik, 3830411I18Rik, Brp44l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915240
    NCBI Gene: 55951
Location & Maps
more
  • Sequence Map
    Chr17:8282904-8297661 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14758 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MPC1, mitochondrial pyruvate carrier 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MPC1, mitochondrial pyruvate carrier 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BRP44L, CGI-129, dJ68L15.3, MPYCD
  • Links
    NCBI Gene ID: 51660
    neXtProt AC: NX_Q9Y5U8

  • Chr Location
    6q27; chr6:166364919-166383013 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9384
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MPC1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MPC1 associations

Human Disease Mouse Models
       Mitochondrial Pyruvate Carrier Deficiency; MPYCD   OMIM: 614741
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
  • All Mutations and Alleles
    4
  • Gene trapped
    2
  • Targeted
    2
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032995 VEGA Gene Model | MGI Sequence Detail 14758 C57BL/6J ±  kb
transcript OTTMUST00000082288 VEGA | MGI Sequence Detail 961 Not Applicable  
polypeptide OTTMUSP00000044089 VEGA | MGI Sequence Detail 167 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    130 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000004821 brain protein 44-like protein
  • InterPro Domains
    IPR005336 Mitochondrial pyruvate carrier
Molecular
Reagents
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  • All nucleic 175
    cDNA 174
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1917947
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 3
  • Earliest
    J:58544 Trachtulec Z, et al., Synteny of orthologous genes conserved in mammals, snake, fly, nematode, and fission yeast. Mamm Genome. 2001 Mar;12(3):227-31
  • Latest
    J:219501 Vacanti NM, et al., Regulation of substrate utilization by the mitochondrial pyruvate carrier. Mol Cell. 2014 Nov 6;56(3):425-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory