Mpc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mpc1
mitochondrial pyruvate carrier 1
MGI:1915240

28 phenotypes from 1 allele in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mpc1^{tm1c(EUCOMM)Wtsi}/Mpc1^{tm1c(EUCOMM)Wtsi} involves: C57BL/6J * C57BL/6N	improved glucose tolerance	J:236662
	increased insulin sensitivity	J:236662
Mpc1^{tm1c(EUCOMM)Wtsi}/Mpc1^{tm1c(EUCOMM)Wtsi} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: C57BL/6 * C57BL/6J * C57BL/6N * DBA	abnormal gluconeogenesis	J:236662
	abnormal mitochondrial physiology	J:236662
	normal behavior/neurological phenotype	J:236662
	decreased body weight	J:236662
	decreased circulating cholesterol level	J:236662
	decreased circulating glucose level	J:236662
	decreased circulating triglyceride level	J:236662
	decreased respiratory quotient	J:236662
	normal homeostasis/metabolism phenotype	J:236662
	improved glucose tolerance	J:236662
	increased circulating ketone body level	J:236662
	increased circulating lactate level	J:236662
	increased fatty acid oxidation	J:236662
	increased triglyceride level	J:236662
Mpc1^{tm1c(EUCOMM)Wtsi}/Mpc1^{tm1c(EUCOMM)Wtsi} Tg(Six3-cre)69Frty/0 involves: C57BL/6N * DBA/2	abnormal cone electrophysiology	J:271892
	abnormal eye physiology	J:271892
	abnormal glucose homeostasis	J:271892
	abnormal metabolism	J:271892
	abnormal Muller cell morphology	J:271892
	abnormal photoreceptor inner segment morphology	J:271892
	abnormal photoreceptor outer segment disc membrane morphology	J:271892
	abnormal retina photoreceptor morphology	J:271892
	abnormal rod electrophysiology	J:271892
	retina degeneration	J:271892
	short photoreceptor outer segment	J:271892
	thin retina inner plexiform layer	J:271892
	thin retina outer nuclear layer	J:271892

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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