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Hcfc2 Gene Detail
Summary
  • Symbol
    Hcfc2
  • Name
    host cell factor C2
  • Synonyms
    1700129L13Rik, fkls
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915183
    NCBI Gene: 67933
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:82696160-82742428 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    577 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915183
protein coding gene Chr10:82696160-82795865 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017579
protein coding gene Chr10:83438103-83483590 (+)
A/J MGP_AJ_G0017559
protein coding gene Chr10:80632231-80678114 (+)
AKR/J MGP_AKRJ_G0017518
protein coding gene Chr10:82880548-82925850 (+)
BALB/cJ MGP_BALBcJ_G0017522
protein coding gene Chr10:80901098-80947025 (+)
C3H/HeJ MGP_C3HHeJ_G0017344
protein coding gene Chr10:82940804-82997341 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017979
protein coding gene Chr10:86369675-86415695 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015664
protein coding gene Chr10:76373026-76417230 (+)
CAST/EiJ MGP_CASTEiJ_G0016911
protein coding gene Chr10:82857024-82905385 (+)
CBA/J MGP_CBAJ_G0017314
protein coding gene Chr10:89926350-89975147 (+)
DBA/2J MGP_DBA2J_G0017420
protein coding gene Chr10:79807061-79853058 (+)
FVB/NJ MGP_FVBNJ_G0017414
protein coding gene Chr10:79037038-79083520 (+)
LP/J MGP_LPJ_G0017492
protein coding gene Chr10:84092583-84140288 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017442
protein coding gene Chr10:91608992-91655910 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018016
protein coding gene Chr10:82809923-82856105 (+)
PWK/PhJ MGP_PWKPhJ_G0016692
protein coding gene Chr10:79683326-79730927 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016482
protein coding gene Chr10:81498797-81551250 (+)
WSB/EiJ MGP_WSBEiJ_G0016970
protein coding gene Chr10:82845005-82891084 (+)



Homology
more
  • Human Ortholog
    HCFC2, host cell factor C2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HCFC2, host cell factor C2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HCF2, HCF-2
  • Links
    NCBI Gene ID: 29915
    neXtProt AC: NX_Q9Y5Z7
    UniProt: Q9Y5Z7

  • Chr Location
    12q23.3; chr12:104064458-104108954 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8337
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HCFC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 4 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for null or severely hypomorphic allele exhibit reduced poly(I:C)-mediated TLR3 signaling and increased mortality following viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020246 Ensembl Gene Model | MGI Sequence Detail 46269 C57BL/6J ±  kb
    transcript ENSMUST00000020478 Ensembl | MGI Sequence Detail 3422 Not Applicable  
    polypeptide ENSMUSP00000020478 Ensembl | MGI Sequence Detail 722 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143736, MGI:5445583
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 7
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:251008 Sun L, et al., HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections. J Exp Med. 2017 Nov 06;214(11):3263-3277

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory